Cognitive inhibition impairments in presymptomatic
C9orf72 mutation
cerebellum
cognitive inhibition
hayling sentence completion test
voxel-based morphometry
Journal
Journal of neurology, neurosurgery, and psychiatry
ISSN: 1468-330X
Titre abrégé: J Neurol Neurosurg Psychiatry
Pays: England
ID NLM: 2985191R
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
17
10
2019
revised:
13
01
2020
accepted:
15
01
2020
pubmed:
15
2
2020
medline:
18
8
2020
entrez:
15
2
2020
Statut:
ppublish
Résumé
To investigate cognitive inhibition in presymptomatic Thirty-eight presymptomatic C9+ individuals younger than 40 years had higher error scores (part B) but equivalent HSCT time to completion (part B-part A) compared to C9- individuals. C9+ individuals older than 40 years had both higher error scores and longer time to completion. HSCT time to completion significantly predicted the proximity to estimated clinical conversion from presymptomatic to symptomatic phase in C9+ individuals (based on the average age at onset of affected relatives in the family). Anatomically, we found that HSCT time to completion was associated with the integrity of the cerebellum. The HSCT represents a good marker of cognitive inhibition impairments in C9+ and of proximity to clinical conversion. This study also highlights the key role of the cerebellum in cognitive inhibition.
Identifiants
pubmed: 32054668
pii: jnnp-2019-322242
doi: 10.1136/jnnp-2019-322242
doi:
Substances chimiques
C9orf72 Protein
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
366-372Subventions
Organisme : CIHR
Pays : Canada
Investigateurs
Carole Aubier Girard
(CA)
Eve Benchetrit
(E)
Hugo Bertin
(H)
Anne Bertrand
(A)
Sandrine Bioux
(S)
Anne Bissery
(A)
Évangéline Bliaux
(É)
Stéphanie Bombois
(S)
Marie-Paule Boncoeur
(MP)
Pascaline Cassagnaud
(P)
Mathieu Chastan
(M)
Yaohua Chen
(Y)
Marie Chupin
(M)
Olivier Colliot
(O)
Philippe Couratier
(P)
Xavier Delbeuck
(X)
Vincent Deramecourt
(V)
Christine Delmaire
(C)
Emmanuel Gerardin
(E)
Claude Hossein-Foucher
(C)
Bruno Dubois
(B)
Marie-Odile Habert
(MO)
Didier Hannequin
(D)
Géraldine Lautrette
(G)
Thibaud Lebouvier
(T)
Isabelle Le Ber
(IL)
Stéphane Lehéricy
(S)
Benjamin Le Toullec
(BL)
Richard Levy
(R)
Olivier Martinaud
(O)
Kelly Martineau
(K)
Marie-Anne Mackowiak
(MA)
Jacques Monteil
(J)
Florence Pasquier
(F)
Grégory Petyt
(G)
Pierre-François Pradat
(PF)
Dorothée Pouliquen
(D)
Assi-Hervé Oya
(AH)
Daisy Rinaldi
(D)
Adeline Rollin-Sillaire
(A)
François Salachas
(F)
Sabrina Sayah
(S)
David Wallon
(D)
Informations de copyright
© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.