The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade.
2019-nCoV
Antivirals
Furin
Maturation protease
SARS-CoV
Spike protein
Journal
Antiviral research
ISSN: 1872-9096
Titre abrégé: Antiviral Res
Pays: Netherlands
ID NLM: 8109699
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
03
02
2020
revised:
07
02
2020
accepted:
08
02
2020
pubmed:
15
2
2020
medline:
20
3
2020
entrez:
15
2
2020
Statut:
ppublish
Résumé
In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.
Identifiants
pubmed: 32057769
pii: S0166-3542(20)30052-8
doi: 10.1016/j.antiviral.2020.104742
pmc: PMC7114094
pii:
doi:
Substances chimiques
Spike Glycoprotein, Coronavirus
0
spike protein, SARS-CoV-2
0
Furin
EC 3.4.21.75
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104742Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Références
Clin Transl Immunology. 2019 Aug 05;8(8):e1073
pubmed: 31406574
Br J Cancer. 1997;75(10):1509-14
pubmed: 9166946
N Engl J Med. 2020 Mar 26;382(13):1199-1207
pubmed: 31995857
Emerg Microbes Infect. 2020 Dec;9(1):221-236
pubmed: 31987001
Nat Rev Drug Discov. 2012 May;11(5):367-83
pubmed: 22679642
J Virol. 2020 Mar 17;94(7):
pubmed: 31996437
PLoS Pathog. 2015 Nov 06;11(11):e1005261
pubmed: 26545254
J Virol. 2010 Dec;84(24):12658-64
pubmed: 20926566
Mol Carcinog. 2017 Mar;56(3):1182-1188
pubmed: 27584082
Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12543-7
pubmed: 16116101
Nat Commun. 2017 Apr 10;8:15092
pubmed: 28393837
Biochim Biophys Acta. 2012 Jan;1824(1):186-94
pubmed: 21801859
J Biol Chem. 1996 Nov 29;271(48):30442-50
pubmed: 8940009
Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15214-9
pubmed: 25288733
J Virol. 2008 Sep;82(17):8887-90
pubmed: 18562523
Cell Mol Life Sci. 2004 Nov;61(21):2738-43
pubmed: 15549175
Exp Biol Med (Maywood). 2008 Dec;233(12):1527-36
pubmed: 18849544
Lancet. 1998 Feb 14;351(9101):472-7
pubmed: 9482438
Mol Cell Biol. 2015 Nov;35(21):3684-700
pubmed: 26283733
Nature. 2003 Nov 27;426(6965):450-4
pubmed: 14647384
Nature. 2013 Nov 28;503(7477):535-8
pubmed: 24172901
Biochem Biophys Res Commun. 1968 Sep 6;32(5):898-902
pubmed: 5682314
ACS Chem Biol. 2017 Sep 15;12(9):2474
pubmed: 28782935
Viruses. 2019 Oct 22;11(10):
pubmed: 31652591
Virus Res. 2015 Apr 16;202:120-34
pubmed: 25445340
Viruses. 2019 Sep 09;11(9):
pubmed: 31505793
Biochimie. 1994;76(3-4):217-25
pubmed: 7819326
Int J Infect Dis. 2020 Mar;92:214-217
pubmed: 32007643
J Biol Chem. 1993 Nov 25;268(33):24887-91
pubmed: 8227051
J Virol. 2010 Sep;84(17):8683-90
pubmed: 20554779
Trends Microbiol. 2015 Aug;23(8):468-78
pubmed: 26206723
Biochim Biophys Acta. 2000 Nov 10;1469(3):121-32
pubmed: 11063880
Nat Rev Microbiol. 2016 Aug;14(8):523-34
pubmed: 27344959
Brain Res. 1999 Nov 27;848(1-2):45-62
pubmed: 10701998
Science. 2005 Sep 16;309(5742):1864-8
pubmed: 16166518