The Phenotype and Functional Activity of Mesenchymal Stromal Cells in Pediatric Patients with Non-Malignant Hematological Diseases.
Adipocytes
/ cytology
Adolescent
Anemia, Sickle Cell
/ metabolism
CD146 Antigen
/ metabolism
Case-Control Studies
Cell Differentiation
/ drug effects
Cell Lineage
Cell Proliferation
/ drug effects
Child
Child, Preschool
Chondrocytes
/ cytology
Dinoprostone
/ metabolism
Female
Humans
Indomethacin
/ pharmacology
Male
Mesenchymal Stem Cells
/ cytology
Osteoblasts
/ cytology
Phenotype
beta-Thalassemia
/ metabolism
mesenchymal stromal cells
non-malignant hematological diseases
severe congenital neutropenia
sickle cell anemia
thalassemia
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
12 02 2020
12 02 2020
Historique:
received:
16
01
2020
revised:
07
02
2020
accepted:
07
02
2020
entrez:
16
2
2020
pubmed:
16
2
2020
medline:
17
2
2021
Statut:
epublish
Résumé
As the biology of mesenchymal stromal cells (MSCs) in patients with non-malignant hematological diseases (NMHD) is poorly understood, in the current study we performed a basic characterization of the phenotype and functional activity of NMHD-MSCs. Bone marrow (BM) of patients with thalassemia major (TM) possessed a significantly higher number of nucleated cells (BM-MNCs)/mL BM than healthy donors (
Identifiants
pubmed: 32059574
pii: cells9020431
doi: 10.3390/cells9020431
pmc: PMC7072753
pii:
doi:
Substances chimiques
CD146 Antigen
0
Dinoprostone
K7Q1JQR04M
Indomethacin
XXE1CET956
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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