Investigation of semi-solid formulations for 3D printing of drugs after prolonged storage to mimic real-life applications.
3D-printing
Hydroxypropyl methylcellulose
Individualized medicine
Levetiracetam
Micro extrusion
Pressure-assisted microsyringe (PAM)
Sustained release
Journal
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
ISSN: 1879-0720
Titre abrégé: Eur J Pharm Sci
Pays: Netherlands
ID NLM: 9317982
Informations de publication
Date de publication:
15 Apr 2020
15 Apr 2020
Historique:
received:
22
07
2019
revised:
16
01
2020
accepted:
11
02
2020
pubmed:
16
2
2020
medline:
15
12
2020
entrez:
16
2
2020
Statut:
ppublish
Résumé
The implementation of tailor-made dosage forms is currently one of the biggest challenges in the health sector. Over the last years, different approaches have been introduced to provide an individual and precise dispensing of the appropriate dose of an active pharmaceutical ingredient (API). A more recent approach, which has been intensively researched in the last years, is 3D-printing of medicines. The aim of this work was to develop printing formulations free of organic solvents for a pressure-assisted microsyringe printing method (PAM), which should also be printable over several days of storage. Furthermore, the printed dosage forms should provide a sustained release of the incorporated API. A mixture of polyvinyl acetate/polyvinylpyrrolidone copolymer (PVAc-PVP), hydroxypropyl methylcellulose (HPMC) and highly dispersed silicon dioxide (SiO
Identifiants
pubmed: 32060006
pii: S0928-0987(20)30055-5
doi: 10.1016/j.ejps.2020.105266
pii:
doi:
Substances chimiques
Delayed-Action Preparations
0
Dosage Forms
0
Hypromellose Derivatives
3NXW29V3WO
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105266Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.