Advances in the Diagnosis and Treatment of Large Granular Lymphocytic Leukemia.
Animals
Antineoplastic Agents
/ adverse effects
Diffusion of Innovation
Forecasting
Humans
Immunosuppressive Agents
/ adverse effects
Leukemia, Large Granular Lymphocytic
/ diagnosis
Molecular Targeted Therapy
/ adverse effects
Predictive Value of Tests
Risk Factors
Signal Transduction
/ drug effects
Treatment Outcome
Autoimmunity
BNZ-1
Large granular lymphocyte leukemia
Organ transplant
STAT3
Journal
Current hematologic malignancy reports
ISSN: 1558-822X
Titre abrégé: Curr Hematol Malig Rep
Pays: United States
ID NLM: 101262565
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
pubmed:
18
2
2020
medline:
22
12
2020
entrez:
17
2
2020
Statut:
ppublish
Résumé
The past decade in LGL leukemia research has seen increased pairing of clinical data with molecular markers, shedding new insights on LGL leukemia pathogenesis and heterogeneity. This review summarizes the current standard of care of LGL leukemia, updates from clinical trials, and our congruent improved understanding of LGL pathogenesis. Various clinical reports have identified associations between stem, bone marrow, and solid organ transplants and incidence of LGL leukemia. There is also a potential for underdiagnosis of LGL leukemia within the rheumatoid arthritis patient population, emphasizing our need for continued study. Preliminary results from the BNZ-1 clinical trial, which targets IL-15 along with IL-2 and IL-9 signaling pathways, show some evidence of clinical response. With advances in our understanding of LGL pathogenesis from both the bench and the clinic, exciting avenues for investigations lie ahead for LGL leukemia.
Identifiants
pubmed: 32062772
doi: 10.1007/s11899-020-00565-6
pii: 10.1007/s11899-020-00565-6
pmc: PMC7234906
mid: NIHMS1582973
doi:
Substances chimiques
Antineoplastic Agents
0
Immunosuppressive Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
103-112Subventions
Organisme : NCI NIH HHS
ID : P30 CA044579
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA178393
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009109
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007267
Pays : United States
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