The Role of Extracellular DNA and Histones in Ischaemia-Reperfusion Injury of the Myocardium.
DAMPs
DNA
Innate immunity
Myocardial infarction
Pyroptosis
Journal
Cardiovascular drugs and therapy
ISSN: 1573-7241
Titre abrégé: Cardiovasc Drugs Ther
Pays: United States
ID NLM: 8712220
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
pubmed:
18
2
2020
medline:
21
10
2020
entrez:
17
2
2020
Statut:
ppublish
Résumé
Despite an increase in the rates of survival in patients suffering myocardial infarction, as yet there is no therapy specifically targeting ischaemia and reperfusion injury of the myocardium. With a greater understanding of immune activation during infarction, more potential treatment targets are now being identified. The innate immune system is believed to play an important role in the myocardium after ischaemia-driven cardiomyocyte death. The release of intracellular contents including DNA into the extracellular space during necrosis and cell rupture is now believed to create a pro-inflammatory milieu which propagates the inflammatory process. DNA and DNA fragments have been shown to activate the innate immune system by acting as Danger-Associated Molecular Patterns (DAMPs), which act as ligands on toll-like receptors (TLRs). Stimulation of TLRs, in turn, can activate intracellular cell death pathways such as pyroptosis. Here, we review the role of DNA fragments during ischaemia and reperfusion, and assess their potential as a target in the quest to preserve cardiomyocyte viability following myocardial infarction.
Identifiants
pubmed: 32062794
doi: 10.1007/s10557-020-06946-6
pii: 10.1007/s10557-020-06946-6
pmc: PMC7093382
doi:
Substances chimiques
Alarmins
0
Cell-Free Nucleic Acids
0
Histones
0
Inflammasomes
0
DNA
9007-49-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
123-131Subventions
Organisme : British Heart Foundation
ID : FS/18/80/33937
Pays : United Kingdom
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