Contribution of the Mesencephalon Indices to Differential Diagnosis of Parkinsonian Disorders.
Aged
Case-Control Studies
Diagnosis, Differential
Female
Humans
Image Interpretation, Computer-Assisted
Magnetic Resonance Imaging
/ methods
Male
Mesencephalon
/ diagnostic imaging
Multiple System Atrophy
/ diagnostic imaging
Parkinson Disease
/ diagnostic imaging
Retrospective Studies
Sensitivity and Specificity
Supranuclear Palsy, Progressive
/ diagnostic imaging
Akdeniz Index
Parkinson disease
progressive supranuclear palsy
Journal
Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes
ISSN: 1488-2361
Titre abrégé: Can Assoc Radiol J
Pays: United States
ID NLM: 8812910
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
pubmed:
18
2
2020
medline:
10
3
2020
entrez:
18
2
2020
Statut:
ppublish
Résumé
This study aimed to assess the sensitivity and specificity of brain stem morphologic changes to differentiate the progressive supranuclear palsy (PSP) from Parkinson disease (PD) and multiple system atrophy (MSA), by single and combined magnetic resonance imaging (MRI) measurements. Peduncle angle (PA), pons area (P), mesencephalon area (M), middle cerebellar peduncles (MCPs), and superior cerebellar peduncles (SCPs) were measured in 14 PSP, 43 PD, 8 MSA patients, and 45 age-matched control participants on T1-weighted MRI. Neurologists clinically diagnosed all patients. Additionally, P/M ratio, MCPs/SCPs ratio, the previously defined Magnetic Resonance Parkinsonism Index, MRPI: (P/M) · (MCP/SCP), and also the Akdeniz Index (AKI) that we termed were calculated, AKI: (P/M) · (PA/180). Two blinded radiologists evaluated all MR images and inter-/intraobserver variations were measured. Both M and SCPs were significantly lower and P/M, MCPs/SCPs, and PA were significantly higher in PSP patients than the other groups ( The Akdeniz Index identified in our study is a practical index with high diagnostic power and can reinforce radiological distinguishing of PSP and PD, which are clinically difficult to distinguish.
Sections du résumé
BACKGROUND AND PURPOSE
OBJECTIVE
This study aimed to assess the sensitivity and specificity of brain stem morphologic changes to differentiate the progressive supranuclear palsy (PSP) from Parkinson disease (PD) and multiple system atrophy (MSA), by single and combined magnetic resonance imaging (MRI) measurements.
MATERIALS AND METHODS
METHODS
Peduncle angle (PA), pons area (P), mesencephalon area (M), middle cerebellar peduncles (MCPs), and superior cerebellar peduncles (SCPs) were measured in 14 PSP, 43 PD, 8 MSA patients, and 45 age-matched control participants on T1-weighted MRI. Neurologists clinically diagnosed all patients. Additionally, P/M ratio, MCPs/SCPs ratio, the previously defined Magnetic Resonance Parkinsonism Index, MRPI: (P/M) · (MCP/SCP), and also the Akdeniz Index (AKI) that we termed were calculated, AKI: (P/M) · (PA/180). Two blinded radiologists evaluated all MR images and inter-/intraobserver variations were measured.
RESULTS
RESULTS
Both M and SCPs were significantly lower and P/M, MCPs/SCPs, and PA were significantly higher in PSP patients than the other groups (
CONCLUSION
CONCLUSIONS
The Akdeniz Index identified in our study is a practical index with high diagnostic power and can reinforce radiological distinguishing of PSP and PD, which are clinically difficult to distinguish.
Identifiants
pubmed: 32062996
doi: 10.1177/0846537119888411
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM