Stereoselective Synthesis of New (2

Carboxylic Acids Proline Pyrrolidines / pharmacology Receptors, Ionotropic Glutamate / metabolism Receptors, N-Methyl-D-Aspartate / metabolism Structure-Activity Relationship
C(sp3)−H activation Electrophysiology Ionotropic glutamate receptors NMDA receptor antagonist Proline analogues

Journal

ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337

Informations de publication

Date de publication:
04 03 2020
Historique:
pubmed: 18 2 2020
medline: 22 6 2021
entrez: 18 2 2020
Statut: ppublish

Résumé

Competitive antagonists for ionotropic glutamate receptors (iGluRs) are highly valuable tool compounds for studying health and disease states in the central nervous system. However, only few subtype selective tool compounds are available and the discovery of antagonists with novel iGluR subtype selectivity profiles remains a profound challenge. In this paper, we report an elaborate structure-activity relationship (SAR) study of the parental scaffold 2,3-

Identifiants

DOI: 10.1021/acschemneuro.0c00003 PMID: 32065744 PMC: PMC7227796
pubmed: 32065744
doi: 10.1021/acschemneuro.0c00003
pmc: PMC7227796
mid: NIHMS1579919
doi:

Substances chimiques

Carboxylic Acids 0
Pyrrolidines 0
Receptors, Ionotropic Glutamate 0
Receptors, N-Methyl-D-Aspartate 0
Proline 9DLQ4CIU6V

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

674-701

Subventions

Organisme : NIGMS NIH HHS
ID : P20 GM103546
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS097536
Pays : United States

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Auteurs

Silke Kayser (S)

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark.

Jacob C Hansen (JC)

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark.

Markus Staudt (M)

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark.

Aleksandra Moroz (A)

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark.

Younes Larsen (Y)

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark.

Piero Temperini (P)

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark.
ORCID: 0000-0003-4951-6879

Feng Yi (F)

Department of Biomedical and Pharmaceutical Sciences, Center for Structural and Functional Neuroscience, and Center for Biomolecular Structure and Dynamics, University of Montana, Missoula, Montana 59812, United States.

Jed T Syrenne (JT)

Department of Biomedical and Pharmaceutical Sciences, Center for Structural and Functional Neuroscience, and Center for Biomolecular Structure and Dynamics, University of Montana, Missoula, Montana 59812, United States.

Niels Krogsgaard-Larsen (N)

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark.

Stylianos Iliadis (S)

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark.

Birgitte Nielsen (B)

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark.

Kasper B Hansen (KB)

Department of Biomedical and Pharmaceutical Sciences, Center for Structural and Functional Neuroscience, and Center for Biomolecular Structure and Dynamics, University of Montana, Missoula, Montana 59812, United States.
ORCID: 0000-0002-3303-4819

Darryl S Pickering (DS)

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark.
ORCID: 0000-0001-8687-6094

Lennart Bunch (L)

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark.
ORCID: 0000-0002-0180-4639

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Stereoselective Synthesis of New (2
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés cycliques › Imino-acides › Proline › Stereoselective Synthesis of New (2
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrrolidines › Stereoselective Synthesis of New (2
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs au glutamate › Récepteurs ionotropes du glutamate › Stereoselective Synthesis of New (2
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs au glutamate › Récepteurs ionotropes du glutamate › Récepteurs du N-méthyl-D-aspartate › Stereoselective Synthesis of New (2
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Stereoselective Synthesis of New (2