Allele-specific expression changes dynamically during T cell activation in HLA and other autoimmune loci.

Alleles Autoimmunity / genetics CD4-Positive T-Lymphocytes CRISPR-Cas Systems Cell Line Gene Expression Regulation Genetic Loci Genetic Variation Genotyping Techniques HLA Antigens / genetics HLA-DQ beta-Chains / genetics Humans Immunity, Cellular Lymphocyte Activation / genetics Promoter Regions, Genetic / genetics T-Lymphocytes, Regulatory

Journal

Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904

Informations de publication

Date de publication:
03 2020
Historique:
received: 26 04 2019
accepted: 13 01 2020
pubmed: 19 2 2020
medline: 15 4 2020
entrez: 19 2 2020
Statut: ppublish

Résumé

Genetic studies have revealed that autoimmune susceptibility variants are over-represented in memory CD4

Identifiants

DOI: 10.1038/s41588-020-0579-4 PMID: 32066938 PMC: PMC7135372
pubmed: 32066938
doi: 10.1038/s41588-020-0579-4
pii: 10.1038/s41588-020-0579-4
pmc: PMC7135372
mid: NIHMS1549636
doi:

Substances chimiques

HLA Antigens 0
HLA-DQ beta-Chains 0
HLA-DQB1 antigen 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

247-253

Subventions

Organisme : NHLBI NIH HHS
ID : HHSN268201500003C
Pays : United States
Organisme : NHGRI NIH HHS
ID : U54 HG003067
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95163
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001079
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95169
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI111224
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95168
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK063491
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201800001C
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95165
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95159
Pays : United States
Organisme : Medical Research Council
ID : MR/R013926/1
Pays : United Kingdom
Organisme : NCATS NIH HHS
ID : UL1 TR000040
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001881
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201000001I
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95160
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL120393
Pays : United States
Organisme : NHGRI NIH HHS
ID : T32 HG002295
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95164
Pays : United States
Organisme : NIGMS NIH HHS
ID : U01 GM092691
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95162
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95161
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001420
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR063759
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201500003I
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG009379
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95167
Pays : United States
Organisme : NIAMS NIH HHS
ID : UH2 AR067677
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL117626
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95166
Pays : United States

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Auteurs

Maria Gutierrez-Arcelus (M)

Center for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
ORCID: 0000-0001-7898-7691

Yuriy Baglaenko (Y)

Center for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
ORCID: 0000-0002-9020-6824

Jatin Arora (J)

Center for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Max Planck Institute for Evolutionary Biology, Plön, Germany.

Susan Hannes (S)

Center for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
ORCID: 0000-0003-4437-8083

Yang Luo (Y)

Center for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
ORCID: 0000-0001-7385-6166

Tiffany Amariuta (T)

Center for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Graduate School of Arts and Sciences, Harvard University, Cambridge, MA, USA.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0003-0121-1726

Nikola Teslovich (N)

Center for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Deepak A Rao (DA)

Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0001-9672-7746

Joerg Ermann (J)

Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0003-3836-9404

A Helena Jonsson (AH)

Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-9558-2474

Cristina Navarrete (C)

Division of Infection and Immunity, University College London, London, UK.

Stephen S Rich (SS)

Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA.
ORCID: 0000-0003-3872-7793

Kent D Taylor (KD)

The Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
ORCID: 0000-0002-2756-4370

Jerome I Rotter (JI)

The Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
ORCID: 0000-0001-7191-1723

Peter K Gregersen (PK)

The Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, USA.

Tonu Esko (T)

Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.

Michael B Brenner (MB)

Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Soumya Raychaudhuri (S)

Center for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org.
Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org.
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA. soumya@broadinstitute.org.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org.
Centre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, University of Manchester, Manchester, UK. soumya@broadinstitute.org.
ORCID: 0000-0002-1901-8265

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Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
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Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Allèles › Allele-specific expression changes dynamically...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Auto-immunité › Allele-specific expression changes dynamically...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Allele-specific expression changes dynamically...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Systèmes CRISPR-Cas › Allele-specific expression changes dynamically...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Allele-specific expression changes dynamically...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Allele-specific expression changes dynamically...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Locus génétiques › Allele-specific expression changes dynamically...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Allele-specific expression changes dynamically...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Techniques de génotypage › Allele-specific expression changes dynamically...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes HLA › Allele-specific expression changes dynamically...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes HLA › Antigènes HLA-D › Antigènes HLA-DQ › Chaines bêta des antigènes HLA-DQ › Allele-specific expression changes dynamically...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Allele-specific expression changes dynamically...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Immunité cellulaire › Allele-specific expression changes dynamically...
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › Allele-specific expression changes dynamically...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Régions promotrices (génétique) › Allele-specific expression changes dynamically...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Allele-specific expression changes dynamically...