Structural basis of cycloaddition in biosynthesis of iboga and aspidosperma alkaloids.
Journal
Nature chemical biology
ISSN: 1552-4469
Titre abrégé: Nat Chem Biol
Pays: United States
ID NLM: 101231976
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
19
07
2019
accepted:
20
12
2019
pubmed:
19
2
2020
medline:
11
4
2020
entrez:
19
2
2020
Statut:
ppublish
Résumé
Cycloaddition reactions generate chemical complexity in a single step. Here we report the crystal structures of three homologous plant-derived cyclases involved in the biosynthesis of iboga and aspidosperma alkaloids. These enzymes act on the same substrate, named angryline, to generate three distinct scaffolds. Mutational analysis reveals how these highly similar enzymes control regio- and stereo-selectivity.
Identifiants
pubmed: 32066966
doi: 10.1038/s41589-019-0460-x
pii: 10.1038/s41589-019-0460-x
pmc: PMC7104359
mid: EMS85308
doi:
Substances chimiques
Alkaloids
0
Carbazoles
0
Indole Alkaloids
0
carbazole
0P2197HHHN
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
383-386Subventions
Organisme : European Research Council
ID : 788301
Pays : International
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