Role of Arginine 214 in the Substrate Specificity of OXA-48.
Amino Acid Substitution
Anti-Bacterial Agents
/ pharmacology
Arginine
/ genetics
Bacterial Proteins
/ genetics
Carbapenems
/ metabolism
Crystallography, X-Ray
Drug Resistance, Bacterial
/ genetics
Enterobacteriaceae
/ drug effects
Imipenem
/ pharmacology
Kinetics
Microbial Sensitivity Tests
Models, Molecular
Mutation
/ genetics
Penicillins
/ metabolism
Substrate Specificity
/ genetics
beta-Lactamases
/ genetics
OXA-232
OXA-48-like
X-ray crystallography
antibiotic resistance
carbapenemase
molecular modeling
oxacillinase
steady-state kinetics
β-lactamase
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
21 04 2020
21 04 2020
Historique:
received:
21
11
2019
accepted:
11
02
2020
pubmed:
20
2
2020
medline:
7
4
2021
entrez:
20
2
2020
Statut:
epublish
Résumé
Increasing numbers of variants of the carbapenem-hydrolyzing class D β-lactamase OXA-48 are identified in
Identifiants
pubmed: 32071047
pii: AAC.02329-19
doi: 10.1128/AAC.02329-19
pmc: PMC7179614
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bacterial Proteins
0
Carbapenems
0
Penicillins
0
temocillin
03QB156W6I
Imipenem
71OTZ9ZE0A
Arginine
94ZLA3W45F
beta-Lactamases
EC 3.5.2.6
carbapenemase
EC 3.5.2.6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 American Society for Microbiology.
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