Carbapenemase-producing Enterobacteriaceae circulating in the Reunion Island, a French territory in the Southwest Indian Ocean.
Adolescent
Adult
Aged
Anti-Bacterial Agents
/ pharmacology
Bacterial Proteins
/ genetics
Bacterial Typing Techniques
Child
Child, Preschool
Enterobacteriaceae
/ classification
Enterobacteriaceae Infections
/ epidemiology
Female
Humans
Infant
Infant, Newborn
Male
Microbial Sensitivity Tests
Middle Aged
Multilocus Sequence Typing
/ methods
Population Surveillance
Retrospective Studies
Reunion
/ epidemiology
Young Adult
beta-Lactamases
/ genetics
Carbapenemase
Epidemiology
French overseas territory
Indian Ocean
NDM
Reunion Island
Journal
Antimicrobial resistance and infection control
ISSN: 2047-2994
Titre abrégé: Antimicrob Resist Infect Control
Pays: England
ID NLM: 101585411
Informations de publication
Date de publication:
19 02 2020
19 02 2020
Historique:
received:
16
08
2019
accepted:
14
02
2020
entrez:
21
2
2020
pubmed:
23
2
2020
medline:
19
5
2021
Statut:
epublish
Résumé
The spread of carbapenemase-producing Enterobacteriaceae (CPE) in the Southwest Indian Ocean area (SIOA) is poorly documented. Reunion Island is a French overseas territory located close to Madagascar and connected with Southern Africa, Indian sub-continent and Europe, with several weekly flights. Here we report the results of the CPE surveillance program in Reunion Island over a six-year period. All CPE were collected between January 2011 and December 2016. Demographics and clinical data of the carrier patients were collected. We determined their susceptibility to antimicrobials, identified the carbapenemases and ESBL by PCR and sequencing, and explored their genetic relationship using pulsed-field gel electrophoresis and multi-locus sequence typing. A total of 61 CPEs isolated from 53 patients were retrieved in 6 public or private laboratories of the island. We found that 69.8% of CPE patients were linked to a foreign country of SIOA and that almost half of CPE cases (47.2%) reached the island through a medical evacuation. The annual number of CPE cases strongly increased over the studied period (one case in 2011 vs. 21 cases in 2016). A proportion of 17.5% of CPE isolates were non-susceptible to colistin. bla Because the hospital of Reunion Island is the only reference healthcare setting of the SIOA, we can reasonably estimate that its CPE epidemiology reflects that of this area. Mauritius was the main provider of foreign CPE cases (35.5%). We also showed that autochthonous isolates of CPEs are mostly polyclonal, thus unrelated to cross-transmission. This demonstrates the local spread of carbapenemase-encoding genes (i.e. bla
Sections du résumé
BACKGROUND
The spread of carbapenemase-producing Enterobacteriaceae (CPE) in the Southwest Indian Ocean area (SIOA) is poorly documented. Reunion Island is a French overseas territory located close to Madagascar and connected with Southern Africa, Indian sub-continent and Europe, with several weekly flights. Here we report the results of the CPE surveillance program in Reunion Island over a six-year period.
METHODS
All CPE were collected between January 2011 and December 2016. Demographics and clinical data of the carrier patients were collected. We determined their susceptibility to antimicrobials, identified the carbapenemases and ESBL by PCR and sequencing, and explored their genetic relationship using pulsed-field gel electrophoresis and multi-locus sequence typing.
RESULTS
A total of 61 CPEs isolated from 53 patients were retrieved in 6 public or private laboratories of the island. We found that 69.8% of CPE patients were linked to a foreign country of SIOA and that almost half of CPE cases (47.2%) reached the island through a medical evacuation. The annual number of CPE cases strongly increased over the studied period (one case in 2011 vs. 21 cases in 2016). A proportion of 17.5% of CPE isolates were non-susceptible to colistin. bla
CONCLUSIONS
Because the hospital of Reunion Island is the only reference healthcare setting of the SIOA, we can reasonably estimate that its CPE epidemiology reflects that of this area. Mauritius was the main provider of foreign CPE cases (35.5%). We also showed that autochthonous isolates of CPEs are mostly polyclonal, thus unrelated to cross-transmission. This demonstrates the local spread of carbapenemase-encoding genes (i.e. bla
Identifiants
pubmed: 32075697
doi: 10.1186/s13756-020-0703-3
pii: 10.1186/s13756-020-0703-3
pmc: PMC7031992
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bacterial Proteins
0
beta-Lactamases
EC 3.5.2.6
carbapenemase
EC 3.5.2.6
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
36Références
Antimicrob Agents Chemother. 2011 Feb;55(2):934-6
pubmed: 21115785
Emerg Infect Dis. 2011 Oct;17(10):1791-8
pubmed: 22000347
J Clin Microbiol. 2012 Nov;50(11):3812
pubmed: 22972814
J Antimicrob Chemother. 2013 Mar;68(3):487-9
pubmed: 23104494
EBioMedicine. 2017 May;19:98-106
pubmed: 28479289
Euro Surveill. 2015;20(45):
pubmed: 26675038
S Afr Med J. 2011 Nov 25;101(12):873-5
pubmed: 22273027
Clin Microbiol Infect. 2012 May;18(5):439-48
pubmed: 22507111
J Clin Microbiol. 1995 Sep;33(9):2233-9
pubmed: 7494007
Antimicrob Agents Chemother. 2014 Jun;58(6):3085-90
pubmed: 24637692
Infect Control Hosp Epidemiol. 2009 Oct;30(10):972-6
pubmed: 19712030
Clin Microbiol Infect. 2012 May;18(5):413-31
pubmed: 22507109
Int J Antimicrob Agents. 2018 Sep;52(3):416-420
pubmed: 29807164
PLoS One. 2013 Jun 11;8(6):e66358
pubmed: 23776664
Antimicrob Agents Chemother. 2011 Mar;55(3):1274-8
pubmed: 21189345
Antimicrob Agents Chemother. 2012 Dec;56(12):6437-40
pubmed: 23070158
Clin Microbiol Rev. 2013 Jul;26(3):361-80
pubmed: 23824364
Euro Surveill. 2017 Feb 9;22(6):
pubmed: 28205502
Clin Chem. 2017 Mar;63(3):723-730
pubmed: 28073895
Future Microbiol. 2011 Jun;6(6):653-66
pubmed: 21707312
Med Mal Infect. 2017 Sep;47(5):333-339
pubmed: 28602387
Antimicrob Agents Chemother. 2015;59(6):3652-5
pubmed: 25845871
Antimicrob Agents Chemother. 2012 Jan;56(1):598-9
pubmed: 22006002
J Antimicrob Chemother. 2016 Nov;71(11):3058-3061
pubmed: 27494907
Antimicrob Agents Chemother. 2018 Jul 27;62(8):
pubmed: 29866863
J Med Microbiol. 2014 Aug;63(Pt 8):1087-92
pubmed: 24855071
J Clin Microbiol. 2005 Aug;43(8):4178-82
pubmed: 16081970
S Afr Med J. 2016 Sep 06;106(10):975-977
pubmed: 27725012
Clin Infect Dis. 2014 Jun;58(12):1658-65
pubmed: 24795329
Int J Antimicrob Agents. 2013 Apr;41(4):325-9
pubmed: 23305656
J Antimicrob Chemother. 2010 Jun;65(6):1119-25
pubmed: 20378670
Med Mal Infect. 2013 Aug;43(8):331-6
pubmed: 23876202
Antimicrob Agents Chemother. 2012 May;56(5):2735-8
pubmed: 22354295
Mol Microbiol. 2006 Jun;60(5):1136-51
pubmed: 16689791
Biomed Res Int. 2014;2014:303104
pubmed: 24707481