Efficacy and safety of a supplement combination for hand osteoarthritis pain: protocol for an internet-based randomised placebo-controlled trial (The RADIANT study).
Australia
Curcumin
/ therapeutic use
Dimethyl Sulfoxide
/ therapeutic use
Double-Blind Method
Hand
/ physiopathology
Humans
Internet
Osteoarthritis
/ drug therapy
Pain Management
Plant Preparations
/ therapeutic use
Quality of Life
Randomized Controlled Trials as Topic
Sulfones
/ therapeutic use
Treatment Outcome
clinical trials
hand & wrist
musculoskeletal disorders
rheumatology
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
18 02 2020
18 02 2020
Historique:
entrez:
21
2
2020
pubmed:
23
2
2020
medline:
13
4
2021
Statut:
epublish
Résumé
Hand osteoarthritis (HOA) is a highly prevalent disabling joint disease. The current management regimens are limited. Potentially as a consequence, many people turn to complementary and alternative medicines for symptomatic relief. A combination of two or more supplements is common in clinical practice; however, evidence for the efficacy of this approach is lacking. The aim of this study is to investigate the efficacy of a supplement combination for treating symptomatic HOA in comparison to placebo. The RADIANT study is an internet-based, parallel, superiority, double-blind, placebo-controlled, randomised, two-arm clinical trial. A participatory design is used to facilitate the study procedures. One hundred and six participants aged over 40 years with painful HOA and structural change on X-ray (Kellgren and Lawrence grade (KLG) ≥2) will be recruited from the community and randomly allocated to receive either a supplement combination composed of: (1) combined supplement containing This protocol has been approved by the University of Sydney Human Research Ethics Committee (HREC No. 2018/766). Dissemination will occur through conferences, social media, scientific publications and PhD thesis. Australian New Zealand Clinical Trials Registry (ACTRN12619000835145); Pre-results.
Identifiants
pubmed: 32075845
pii: bmjopen-2019-035672
doi: 10.1136/bmjopen-2019-035672
pmc: PMC7044939
doi:
Substances chimiques
Plant Preparations
0
Sulfones
0
dimethyl sulfone
9H4PO4Z4FT
Curcumin
IT942ZTH98
Dimethyl Sulfoxide
YOW8V9698H
Banques de données
ANZCTR
['ACTRN12619000835145']
Types de publication
Clinical Trial Protocol
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e035672Informations de copyright
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: DJH is supported by an NHMRC Practitioner Fellowship and provides consulting advice for Merck Serono, TLC Bio, Tissuegene and Pfizer. Unity Health provides the Sydney Pharmacy School for a researcher’s salary for a project led by AM that maintains a database of herb–drug interaction. AM has served as pharmacokinetic consult to BOD Australia on a study investigating cannabidiol bioavailability (ACTRN12618000391279).
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