Stochastic pulsing of gene expression enables the generation of spatial patterns in Bacillus subtilis biofilms.
Bacillus subtilis
/ genetics
Bacterial Proteins
/ genetics
Biofilms
/ growth & development
Gene Expression Regulation, Bacterial
Genetic Heterogeneity
Microscopy, Fluorescence
Models, Biological
Sigma Factor
/ genetics
Spores, Bacterial
/ genetics
Stochastic Processes
Stress, Physiological
Time-Lapse Imaging
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
19 02 2020
19 02 2020
Historique:
received:
10
08
2018
accepted:
17
12
2019
entrez:
21
2
2020
pubmed:
23
2
2020
medline:
30
4
2020
Statut:
epublish
Résumé
Stochastic pulsing of gene expression can generate phenotypic diversity in a genetically identical population of cells, but it is unclear whether it has a role in the development of multicellular systems. Here, we show how stochastic pulsing of gene expression enables spatial patterns to form in a model multicellular system, Bacillus subtilis bacterial biofilms. We use quantitative microscopy and time-lapse imaging to observe pulses in the activity of the general stress response sigma factor σ
Identifiants
pubmed: 32075967
doi: 10.1038/s41467-020-14431-9
pii: 10.1038/s41467-020-14431-9
pmc: PMC7031267
doi:
Substances chimiques
Bacterial Proteins
0
Sigma Factor
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
950Références
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