Vitamin C alleviates acute enterocolitis in Campylobacter jejuni infected mice.
Acute Disease
Animals
Apoptosis
/ drug effects
Ascorbic Acid
/ pharmacology
Campylobacter Infections
/ drug therapy
Campylobacter jejuni
/ physiology
Colon
/ drug effects
Enterocolitis
/ drug therapy
Inflammation
/ pathology
Inflammation Mediators
/ metabolism
Interleukin-10
/ deficiency
Mice, Inbred C57BL
Treatment Outcome
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
19 02 2020
19 02 2020
Historique:
received:
09
08
2019
accepted:
03
02
2020
entrez:
21
2
2020
pubmed:
23
2
2020
medline:
13
11
2020
Statut:
epublish
Résumé
Human foodborne infections with the zoonotic pathogen Campylobacter jejuni are on the rise and constitute a significant socioeconomic burden worldwide. The health-beneficial, particularly anti-inflammatory effects of vitamin C (ascorbate) are well known. In our preclinical intervention study, we assessed potential anti-pathogenic and immunomodulatory effects of ascorbate in C. jejuni-infected secondary abiotic IL-10
Identifiants
pubmed: 32076081
doi: 10.1038/s41598-020-59890-8
pii: 10.1038/s41598-020-59890-8
pmc: PMC7031283
doi:
Substances chimiques
Inflammation Mediators
0
Interleukin-10
130068-27-8
Ascorbic Acid
PQ6CK8PD0R
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2921Références
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