Orosomucoid-like 3 Supports Rhinovirus Replication in Human Epithelial Cells.
A549 Cells
Asthma
/ etiology
Bronchi
/ cytology
Cells, Cultured
Chromosomes, Human, Pair 17
/ genetics
Endoplasmic Reticulum Stress
Epithelial Cells
/ virology
Fatty Acids, Monounsaturated
/ pharmacology
Genetic Predisposition to Disease
Genotype
HeLa Cells
Humans
Interferon-beta
/ biosynthesis
Membrane Proteins
/ antagonists & inhibitors
Nasal Mucosa
/ cytology
Picornaviridae Infections
/ complications
RNA Interference
RNA, Small Interfering
/ genetics
Recombinant Proteins
/ metabolism
Rhinovirus
/ genetics
Serine C-Palmitoyltransferase
/ antagonists & inhibitors
Sphingolipids
/ metabolism
Taurochenodeoxycholic Acid
/ pharmacology
Virus Replication
/ drug effects
ORMDL3
SPT
asthma
rhinovirus
unfolded protein response
Journal
American journal of respiratory cell and molecular biology
ISSN: 1535-4989
Titre abrégé: Am J Respir Cell Mol Biol
Pays: United States
ID NLM: 8917225
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
pubmed:
23
2
2020
medline:
21
10
2020
entrez:
21
2
2020
Statut:
ppublish
Résumé
Polymorphism at the 17q21 gene locus and wheezing responses to rhinovirus (RV) early in childhood conspire to increase the risk of developing asthma. However, the mechanisms mediating this gene-environment interaction remain unclear. In this study, we investigated the impact of one of the 17q21-encoded genes,
Identifiants
pubmed: 32078788
doi: 10.1165/rcmb.2019-0237OC
pmc: PMC7258826
doi:
Substances chimiques
Fatty Acids, Monounsaturated
0
Membrane Proteins
0
ORMDL3 protein, human
0
RNA, Small Interfering
0
Recombinant Proteins
0
Sphingolipids
0
Taurochenodeoxycholic Acid
516-35-8
ursodoxicoltaurine
60EUX8MN5X
Interferon-beta
77238-31-4
Serine C-Palmitoyltransferase
EC 2.3.1.50
thermozymocidin
YRM4E8R9ST
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
783-792Subventions
Organisme : NIGMS NIH HHS
ID : P41 GM108538
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI136500
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI121808
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI104317
Pays : United States
Commentaires et corrections
Type : CommentIn
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