Radiogenomic-Based Survival Risk Stratification of Tumor Habitat on Gd-T1w MRI Is Associated with Biological Processes in Glioblastoma.
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
/ genetics
Brain Neoplasms
/ diagnostic imaging
Female
Gene Expression Regulation, Neoplastic
Glioblastoma
/ diagnostic imaging
Humans
Image Interpretation, Computer-Assisted
/ methods
Magnetic Resonance Imaging
/ methods
Male
Middle Aged
Mutation
Prognosis
Risk Assessment
/ methods
Signal Transduction
Survival Rate
Young Adult
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
15 04 2020
15 04 2020
Historique:
received:
05
08
2019
revised:
11
10
2019
accepted:
14
01
2020
pubmed:
23
2
2020
medline:
28
1
2021
entrez:
22
2
2020
Statut:
ppublish
Résumé
To (i) create a survival risk score using radiomic features from the tumor habitat on routine MRI to predict progression-free survival (PFS) in glioblastoma and (ii) obtain a biological basis for these prognostic radiomic features, by studying their radiogenomic associations with molecular signaling pathways. Two hundred three patients with pretreatment Gd-T1w, T2w, T2w-FLAIR MRI were obtained from 3 cohorts: The Cancer Imaging Archive (TCIA; Twenty-five radiomic features from the tumor habitat yielded the RRS. A combination of RRS with clinical (age and gender) and molecular features (MGMT and IDH status) resulted in a concordance index of 0.81 ( Our findings suggest that prognostic radiomic features from routine Gd-T1w MRI may also be significantly associated with key biological processes that affect response to chemotherapy in GBM.
Identifiants
pubmed: 32079590
pii: 1078-0432.CCR-19-2556
doi: 10.1158/1078-0432.CCR-19-2556
pmc: PMC7165059
mid: NIHMS1551445
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1866-1876Subventions
Organisme : NCI NIH HHS
ID : R01 CA216579
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA094186
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA136535
Pays : United States
Organisme : NIBIB NIH HHS
ID : R43 EB015199
Pays : United States
Organisme : NCI NIH HHS
ID : U24 CA199374
Pays : United States
Organisme : BLRD VA
ID : I01 BX004121
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA239055
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA220581
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA202752
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA208236
Pays : United States
Informations de copyright
©2020 American Association for Cancer Research.
Références
PLoS One. 2018 Aug 31;13(8):e0200730
pubmed: 30169514
Cancer Res. 2011 Jun 15;71(12):4055-60
pubmed: 21628493
Science. 2018 May 11;360(6389):660-663
pubmed: 29748285
Neuro Oncol. 2017 Jan;19(1):128-137
pubmed: 27502248
Bioinformatics. 2011 Jun 15;27(12):1739-40
pubmed: 21546393
Cancer Manag Res. 2018 Oct 04;10:4229-4235
pubmed: 30323678
Nucleic Acids Res. 2017 Jul 3;45(W1):W130-W137
pubmed: 28472511
Neuroimage Clin. 2018;20:1070-1077
pubmed: 30366279
Clin Cancer Res. 2017 Aug 15;23(16):4724-4734
pubmed: 28428190
Lancet. 2016 Oct 15;388(10054):1883-1892
pubmed: 27567279
Clin Cancer Res. 2018 Dec 15;24(24):6288-6299
pubmed: 30054278
IEEE Trans Med Imaging. 2010 Jun;29(6):1310-20
pubmed: 20378467
AJNR Am J Neuroradiol. 2018 Dec;39(12):2187-2193
pubmed: 30385468
Radiology. 1993 Oct;189(1):15-26
pubmed: 8372185
Neuro Oncol. 2018 May 18;20(6):848-857
pubmed: 29036412
JAMA Netw Open. 2019 Apr 5;2(4):e192561
pubmed: 31002322
Cancer Biol Med. 2015 Sep;12(3):223-37
pubmed: 26487967
J Neurooncol. 2016 Feb;126(3):567-75
pubmed: 26614518
N Engl J Med. 2018 Nov 29;379(22):2108-2121
pubmed: 30345906
Sci Rep. 2018 Jan 8;8(1):7
pubmed: 29311558
Ann Oncol. 2017 Jul 1;28(7):1448-1456
pubmed: 28407030
Eur Radiol. 2017 Oct;27(10):4188-4197
pubmed: 27778090
J Digit Imaging. 2013 Dec;26(6):1045-57
pubmed: 23884657
Neuro Oncol. 2015 Oct;17(10):1322-32
pubmed: 26203067
Radiology. 2019 Mar;290(3):783-792
pubmed: 30561278
Magn Reson Imaging. 2012 Nov;30(9):1323-41
pubmed: 22770690
CA Cancer J Clin. 2019 Jan;69(1):7-34
pubmed: 30620402
Nat Genet. 2000 May;25(1):25-9
pubmed: 10802651
Neuro Oncol. 2014 May;16(5):696-706
pubmed: 24335699
J Neurooncol. 2017 Dec;135(3):621-627
pubmed: 28956223
Bioinformatics. 2010 Oct 1;26(19):2363-7
pubmed: 20688976
J Neurooncol. 2018 Oct;140(1):75-82
pubmed: 29936695
Sci Data. 2017 Sep 05;4:170117
pubmed: 28872634
PLoS One. 2011;6(10):e25451
pubmed: 21998659
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Nature. 2009 Nov 5;462(7269):108-12
pubmed: 19847166
Oncologist. 2017 May;22(5):570-575
pubmed: 28360216
Cancer Res. 2013 Mar 1;73(5):1559-69
pubmed: 23243024
Nature. 2008 Oct 23;455(7216):1061-8
pubmed: 18772890
BMC Cancer. 2018 Apr 3;18(1):377
pubmed: 29614978
Hum Brain Mapp. 2010 May;31(5):798-819
pubmed: 20017133
Nucleic Acids Res. 2017 Jan 4;45(D1):D331-D338
pubmed: 27899567
Differentiation. 2006 Dec;74(9-10):481-7
pubmed: 17177845
Brainlesion. 2016;9556:144-155
pubmed: 28725877
Lung Cancer. 2018 Jan;115:34-41
pubmed: 29290259
N Engl J Med. 2015 Jun 25;372(26):2481-98
pubmed: 26061751
J Med Imaging (Bellingham). 2018 Jan;5(1):011018
pubmed: 29340286
N Engl J Med. 2005 Mar 10;352(10):987-96
pubmed: 15758009
Neuro Oncol. 2010 Feb;12(2):116-21
pubmed: 20150378
Medicine (Baltimore). 2016 Feb;95(7):e2830
pubmed: 26886640