Non-communicable respiratory disease and air pollution exposure in Malawi: a prospective cohort study.
Adult
Air Pollution, Indoor
/ adverse effects
Carbon Monoxide
/ toxicity
Cooking
/ instrumentation
Environmental Exposure
/ adverse effects
Environmental Monitoring
Female
Forced Expiratory Volume
Humans
Longitudinal Studies
Lung
/ physiopathology
Malawi
/ epidemiology
Male
Middle Aged
Particulate Matter
/ toxicity
Prospective Studies
Respiratory Tract Diseases
/ epidemiology
Rural Population
Symptom Assessment
Vital Capacity
clinical Epidemiology
lung Physiology
Journal
Thorax
ISSN: 1468-3296
Titre abrégé: Thorax
Pays: England
ID NLM: 0417353
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
09
08
2019
revised:
09
12
2019
accepted:
06
01
2020
pubmed:
23
2
2020
medline:
6
8
2020
entrez:
22
2
2020
Statut:
ppublish
Résumé
There are no population-based studies from sub-Saharan Africa describing longitudinal lung function in adults. To explore the lung function trajectories and their determinants, including the effects of air pollution exposures and the cleaner-burning biomass-fuelled cookstove intervention of the Cooking and Pneumonia Study (CAPS), in adults living in rural Malawi. We assessed respiratory symptoms and exposures, spirometry and measured 48-hour personal exposure to fine particulate matter (PM We recruited 1481 adults, mean (SD) age 43.8 (17.8) years, including 523 participants from CAPS households (271 intervention; 252 controls), and collected multiple spirometry and air pollution measurements for 654 (44%) and 929 (63%), respectively. Compared with Global Lung Function Initiative African-American reference ranges, mean (SD) FEV We did not observe accelerated lung function decline in this cohort of Malawian adults, compared with that reported in healthy, non-smoking populations from high-income countries; this suggests that the lung function deficits we measured in adulthood may have origins in early life.
Identifiants
pubmed: 32079666
pii: thoraxjnl-2019-213941
doi: 10.1136/thoraxjnl-2019-213941
pmc: PMC7063402
doi:
Substances chimiques
Particulate Matter
0
Carbon Monoxide
7U1EE4V452
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
220-226Subventions
Organisme : Medical Research Council
ID : MR/K006533/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L002515/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P022006/1
Pays : United Kingdom
Informations de copyright
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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