Microbial and enzymatic strategies for the production of L-ribose.
Biological production
Isomerase
L-Arabinose
L-Ribose
L-Ribulose
Journal
Applied microbiology and biotechnology
ISSN: 1432-0614
Titre abrégé: Appl Microbiol Biotechnol
Pays: Germany
ID NLM: 8406612
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
15
01
2020
accepted:
13
02
2020
revised:
09
02
2020
pubmed:
24
2
2020
medline:
29
12
2020
entrez:
24
2
2020
Statut:
ppublish
Résumé
L-Ribose is a non-naturally occurring pentose that recently has become known for its potential application in the pharmaceutical industry, as it is an ideal starting material for use in synthesizing L-nucleosides analogues, an important class of antiviral drugs. In the past few decades, the synthesis of L-ribose has been mainly undertaken through the chemical route. However, chemical synthesis of L-ribose is difficult to achieve on an industrial scale. Therefore, the biotechnological production of L-ribose has gained considerable attention, as it exhibits many merits over the chemical approaches. The present review focuses on various biotechnological strategies for the production of L-ribose through microbial biotransformation and enzymatic catalysis, and in particular on an analysis and comparison of the synthetic methods and different enzymes. The physiological functions and applications of L-ribose are also elucidated. In addition, different sugar isomerases involved in the production of L-ribose from a number of sources are discussed in detail with regard to their biochemical properties. Furthermore, analysis of the separation issues of L-ribose from the reaction solution and different purification methods is presented.Key points • l -Arabinose, l -ribulose and ribitol can be used to produce l -ribose by enzymes. • Five enzymes are systematically introduced for production of l -ribose. • Microbial transformation and enzymatic methods are promising for yielding l -ribose.
Identifiants
pubmed: 32088757
doi: 10.1007/s00253-020-10471-9
pii: 10.1007/s00253-020-10471-9
doi:
Substances chimiques
Enzymes, Immobilized
0
Ribose
681HV46001
Arabinose
B40ROO395Z
Isomerases
EC 5.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3321-3329Références
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