Severe neonatal anemia increases intestinal permeability by disrupting epithelial adherens junctions.


Journal

American journal of physiology. Gastrointestinal and liver physiology
ISSN: 1522-1547
Titre abrégé: Am J Physiol Gastrointest Liver Physiol
Pays: United States
ID NLM: 100901227

Informations de publication

Date de publication:
01 04 2020
Historique:
pubmed: 25 2 2020
medline: 25 7 2020
entrez: 25 2 2020
Statut: ppublish

Résumé

Anemia is a frequent diagnosis in critically ill infants, but the clinical implications of severe anemia in these patients remain unclear. In this study, we examined preweaned mice to investigate the effects of severe anemia during early infancy on gut mucosal permeability. C57BL/6 mice were subjected to timed phlebotomy between

Identifiants

pubmed: 32090604
doi: 10.1152/ajpgi.00324.2019
pmc: PMC7191465
doi:

Substances chimiques

Cadherins 0
Cdh1 protein, mouse 0
MicroRNAs 0
RNA, Messenger 0
mirnlet7e microRNA, mouse 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

G705-G716

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL124078
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL124099
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL151107
Pays : United States

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Auteurs

Krishnan MohanKumar (K)

Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, Florida.
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Kopperuncholan Namachivayam (K)

Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, Florida.
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Nithya Sivakumar (N)

Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, Florida.

Natascha G Alves (NG)

Department of Molecular Pharmacology and Physiology, College of Medicine, University of South Florida, Tampa, Florida.

Venkataramana Sidhaye (V)

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Jayanta K Das (JK)

Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Yerin Chung (Y)

Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Jerome W Breslin (JW)

Department of Molecular Pharmacology and Physiology, College of Medicine, University of South Florida, Tampa, Florida.

Akhil Maheshwari (A)

Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, Florida.
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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Classifications MeSH