β2 Integrins-Multi-Functional Leukocyte Receptors in Health and Disease.
Animals
Autoantigens
/ immunology
Autoimmune Diseases
/ metabolism
CD18 Antigens
/ genetics
Cell Adhesion
/ genetics
Cell Movement
/ genetics
Humans
Infections
/ immunology
Leukocyte-Adhesion Deficiency Syndrome
/ genetics
Leukocytes
/ immunology
Lymphocyte Function-Associated Antigen-1
/ immunology
Macrophage-1 Antigen
/ immunology
Neoplasms
/ genetics
Non-Fibrillar Collagens
/ immunology
Phagocytosis
/ genetics
Collagen Type XVII
LAD-I
LFA-1
MAC-1
autoimmune disease
cancer
infection
leukocytes
migration
phagocytosis
β2 integrin
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 Feb 2020
19 Feb 2020
Historique:
received:
06
01
2020
revised:
11
02
2020
accepted:
14
02
2020
entrez:
26
2
2020
pubmed:
26
2
2020
medline:
5
1
2021
Statut:
epublish
Résumé
β2 integrins are heterodimeric surface receptors composed of a variable α (CD11a-CD11d) and a constant β (CD18) subunit and are specifically expressed by leukocytes. The α subunit defines the individual functional properties of the corresponding β2 integrin, but all β2 integrins show functional overlap. They mediate adhesion to other cells and to components of the extracellular matrix (ECM), orchestrate uptake of extracellular material like complement-opsonized pathogens, control cytoskeletal organization, and modulate cell signaling. This review aims to delineate the tremendous role of β2 integrins for immune functions as exemplified by the phenotype of LAD-I (leukocyte adhesion deficiency 1) patients that suffer from strong recurrent infections. These immune defects have been largely attributed to impaired migratory and phagocytic properties of polymorphonuclear granulocytes. The molecular base for this inherited disease is a functional impairment of β2 integrins due to mutations within the CD18 gene. LAD-I patients are also predisposed for autoimmune diseases. In agreement, polymorphisms within the CD11b gene have been associated with autoimmunity. Consequently, β2 integrins have received growing interest as targets in the treatment of autoimmune diseases. Moreover, β2 integrin activity on leukocytes has been implicated in tumor development.
Identifiants
pubmed: 32092981
pii: ijms21041402
doi: 10.3390/ijms21041402
pmc: PMC7073085
pii:
doi:
Substances chimiques
Autoantigens
0
CD18 Antigens
0
Lymphocyte Function-Associated Antigen-1
0
Macrophage-1 Antigen
0
Non-Fibrillar Collagens
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : TR156, B11
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
PLoS One. 2014 Nov 19;9(11):e112064
pubmed: 25409021
Biophys J. 2013 Dec 3;105(11):2517-27
pubmed: 24314082
Immunology. 2018 Jul;154(3):383-393
pubmed: 29512837
Arthritis Rheum. 1994 Jul;37(7):992-9
pubmed: 7912930
Blood. 2009 Jun 4;113(23):5801-10
pubmed: 19346499
Haematologica. 2018 Jun;103(6):e264-e267
pubmed: 29472353
J Neuroimmunol. 2009 Jan 3;206(1-2):22-7
pubmed: 19010554
J Immunol. 1998 Dec 15;161(12):6463-7
pubmed: 9862668
Blood. 2002 Jan 1;99(1):336-41
pubmed: 11756189
Front Immunol. 2018 Nov 26;9:2716
pubmed: 30534123
J Cell Biol. 2013 Nov 25;203(4):629-42
pubmed: 24385486
Cold Spring Harb Perspect Biol. 2012 Aug 01;4(8):a007401
pubmed: 22855722
Immunity. 2010 Sep 24;33(3):340-50
pubmed: 20850356
J Invest Dermatol. 2009 May;129(5):1100-14
pubmed: 19242511
Front Immunol. 2018 Dec 12;9:2904
pubmed: 30631321
Vet Pathol. 2013 Jan;50(1):7-22
pubmed: 23345459
Immunity. 2016 Oct 18;45(4):831-846
pubmed: 27760339
Cell Immunol. 2016 Nov;309:32-36
pubmed: 27394077
Immunol Lett. 2017 Sep;189:64-72
pubmed: 28554712
Cells. 2019 Jul 17;8(7):
pubmed: 31319592
Cell Mol Life Sci. 2019 Apr;76(8):1447-1458
pubmed: 30747250
Blood. 2006 Aug 1;108(3):947-55
pubmed: 16614246
Cell Rep. 2018 Jul 31;24(5):1151-1162
pubmed: 30067972
Front Immunol. 2019 May 22;10:1078
pubmed: 31231358
J Immunol. 2008 Feb 1;180(3):1971-8
pubmed: 18209096
Front Immunol. 2016 Mar 07;7:70
pubmed: 27014259
Pharmacol Ther. 2015 Mar;147:123-135
pubmed: 25448040
EMBO J. 2000 Jun 1;19(11):2525-36
pubmed: 10835351
Front Immunol. 2019 Feb 04;10:123
pubmed: 30778357
Hum Immunol. 2014 Feb;75(2):119-23
pubmed: 24269694
Gut. 1996 Oct;39(4):605-8
pubmed: 8944573
Am J Respir Cell Mol Biol. 2015 Dec;53(6):793-801
pubmed: 25909334
J Nutr. 2011 Jun;141(6):1172-80
pubmed: 21508205
Infect Immun. 2013 Apr;81(4):1140-51
pubmed: 23357382
Front Immunol. 2016 Mar 07;7:68
pubmed: 27014258
Sci Signal. 2017 Dec 12;10(509):
pubmed: 29233918
J Immunol. 1990 Jun 15;144(12):4579-86
pubmed: 1972160
J Infect Dis. 2005 May 15;191(10):1755-60
pubmed: 15838804
J Immunol. 2006 Apr 15;176(8):4914-22
pubmed: 16585587
J Biol Chem. 2007 Jan 12;282(2):968-75
pubmed: 17107954
Front Med (Lausanne). 2018 Mar 15;5:52
pubmed: 29600248
Nat Commun. 2013;4:2813
pubmed: 24264377
Proc Natl Acad Sci U S A. 2005 May 3;102(18):6437-42
pubmed: 15851656
Blood. 2016 Jan 21;127(3):314-24
pubmed: 26468229
F1000Res. 2016 Oct 4;5:
pubmed: 27781085
Am J Clin Dermatol. 2017 Aug;18(4):513-528
pubmed: 28247089
Cancer Res. 2009 Apr 1;69(7):3121-30
pubmed: 19293181
Clin Epigenetics. 2014 Nov 11;6(1):25
pubmed: 25414732
Stem Cell Res Ther. 2016 Mar 17;7:43
pubmed: 26987803
Sci Signal. 2014 Oct 07;7(346):ra96
pubmed: 25292215
Cancer Res. 2009 Dec 15;69(24):9281-90
pubmed: 19934331
Eur J Immunol. 2009 Nov;39(11):3217-27
pubmed: 19750481
J Allergy Clin Immunol Pract. 2018 Jul - Aug;6(4):1418-1420.e10
pubmed: 29371071
Am J Transl Res. 2013 Dec 01;6(1):16-27
pubmed: 24349618
Eur J Immunol. 2016 Oct;46(10):2454-2466
pubmed: 27338697
Int J Mol Sci. 2018 Sep 20;19(10):
pubmed: 30241315
J Exp Med. 1998 Jul 6;188(1):119-31
pubmed: 9653089
Eur J Immunol. 2000 Sep;30(9):2729-40
pubmed: 11009109
PLoS One. 2014 Aug 18;9(8):e105561
pubmed: 25133611
Genome Biol. 2007;8(5):215
pubmed: 17543136
J Immunol. 2016 Apr 1;196(7):3019-31
pubmed: 26921307
Mol Cell Biol. 2017 Mar 31;37(8):
pubmed: 28137909
Blood. 2006 Feb 15;107(4):1643-50
pubmed: 16239428
J Biol Chem. 2014 Aug 15;289(33):23256-63
pubmed: 24975416
Sci Immunol. 2018 Dec 7;3(30):
pubmed: 30530726
Cell Microbiol. 2004 May;6(5):401-10
pubmed: 15056211
Eur J Immunol. 2017 Apr;47(4):637-645
pubmed: 28191643
Inflamm Bowel Dis. 2012 Dec;18(12):2360-70
pubmed: 22488891
J Immunol. 2005 Nov 15;175(10):6327-33
pubmed: 16272284
J Immunotoxicol. 2016;13(2):148-56
pubmed: 25746395
Curr Opin Immunol. 2018 Apr;51:76-82
pubmed: 29547768
J Immunol. 2012 Oct 1;189(7):3714-23
pubmed: 22933624
Eur J Immunol. 2010 Dec;40(12):3403-12
pubmed: 21108463
Breast Cancer Res. 2015 Sep 04;17:124
pubmed: 26341640
Immunity. 2003 Sep;19(3):391-402
pubmed: 14499114
Cells. 2018 Mar 26;7(4):
pubmed: 29587442
J Immunol. 2014 Apr 15;192(8):3559-68
pubmed: 24646736
J Immunol. 2003 May 15;170(10):5228-34
pubmed: 12734371
Cochrane Database Syst Rev. 2018 Aug 01;8:CD006097
pubmed: 30068022
Blood. 2018 Jul 5;132(1):78-88
pubmed: 29724896
J Immunol. 2005 Mar 15;174(6):3668-75
pubmed: 15749905
Eur Rev Med Pharmacol Sci. 2019 Apr;23(7):2750-2755
pubmed: 31002125
Eur J Immunol. 2013 Mar;43(3):779-92
pubmed: 23310953
J Immunol. 2013 Jan 1;190(1):115-25
pubmed: 23209319
J Immunol. 2018 Jun 15;200(12):4012-4023
pubmed: 29703862
Proc Natl Acad Sci U S A. 2010 May 4;107(18):8363-8
pubmed: 20404138
Nature. 1996 May 2;381(6577):75-7
pubmed: 8609992
Cell Immunol. 2019 Sep;343:103713
pubmed: 29129292
J Clin Immunol. 2016 Oct;36(7):627-30
pubmed: 27492259
J Invest Dermatol. 2015 Sep;135(9):2249-2257
pubmed: 25918984
Br J Haematol. 2015 Apr;169(2):286-9
pubmed: 25322676
Blood. 2011 Jul 7;118(1):107-15
pubmed: 21562043
J Immunol. 2015 Mar 1;194(5):2168-79
pubmed: 25624455
Front Immunol. 2019 Aug 27;10:2014
pubmed: 31507607
J Bone Miner Res. 2013 Jan;28(1):135-49
pubmed: 22893614
J Biol Chem. 2003 Nov 14;278(46):45720-9
pubmed: 12941957
Am J Physiol Lung Cell Mol Physiol. 2006 Aug;291(2):L200-7
pubmed: 16461431
Annu Rev Immunol. 2002;20:825-52
pubmed: 11861619
J Exp Med. 2016 Jul 25;213(8):1609-25
pubmed: 27354546
Biomed Res Int. 2016;2016:9089610
pubmed: 26977415
Front Immunol. 2018 Sep 25;9:2152
pubmed: 30319617
Nat Commun. 2018 Nov 29;9(1):5058
pubmed: 30498196
Mediators Inflamm. 2017;2017:1953680
pubmed: 28293065
Microb Pathog. 2016 May;94:21-6
pubmed: 26375893
Hum Gene Ther. 2016 Sep;27(9):668-78
pubmed: 27056660
Biorheology. 2015;52(5-6):353-77
pubmed: 26684674
Int J Mol Sci. 2018 Feb 02;19(2):
pubmed: 29393909
J Exp Med. 2007 Jul 9;204(7):1519-24
pubmed: 17562817
J Biol Chem. 2011 Oct 7;286(40):34777-87
pubmed: 21840991
BMC Cancer. 2017 Dec 06;17(1):827
pubmed: 29207960
J Immunol. 2008 Sep 1;181(5):2953-9
pubmed: 18713965
Annu Rev Immunol. 2016 May 20;34:335-68
pubmed: 26907215
J Leukoc Biol. 2000 Jul;68(1):73-80
pubmed: 10914492
Nat Rev Immunol. 2014 Aug;14(8):571-8
pubmed: 25033907
J Immunol. 2014 Jan 1;192(1):324-37
pubmed: 24259506
Blood. 2012 May 3;119(18):4275-82
pubmed: 22431571
Ann N Y Acad Sci. 2012 Feb;1250:50-5
pubmed: 22276660
J Clin Invest. 2017 Jun 30;127(7):2464-2472
pubmed: 28530643
Blood. 2003 Jan 1;101(1):253-8
pubmed: 12485936
Mol Biol Cell. 2018 Feb 15;29(4):408-418
pubmed: 29282280
J Immunol Methods. 2015 Aug;423:40-4
pubmed: 25967948
Essays Biochem. 2019 Oct 31;63(5):535-551
pubmed: 31444228
Int J Clin Exp Pathol. 2015 Dec 01;8(12):15642-51
pubmed: 26884833
Pediatr Pathol. 1992 Jan-Feb;12(1):119-30
pubmed: 1348581
Infect Immun. 2011 Apr;79(4):1546-58
pubmed: 21245270
PLoS One. 2015 Jul 16;10(7):e0132835
pubmed: 26181635
Nat Immunol. 2003 Aug;4(8):741-8
pubmed: 12845325
J Immunol. 2007 Aug 15;179(4):2349-58
pubmed: 17675496
J Immunol. 2008 Jan 1;180(1):590-600
pubmed: 18097061
Immunol Res. 2016 Apr;64(2):476-82
pubmed: 26434744
Blood. 1987 Jun;69(6):1622-30
pubmed: 3555649
Clin Immunol. 2018 Jun;191:75-80
pubmed: 29548898
J Cell Sci. 2012 Sep 1;125(Pt 17):4049-57
pubmed: 22685325
Lancet Neurol. 2017 Nov;16(11):925-933
pubmed: 28969984
J Invest Dermatol. 2008 May;128(5):1182-91
pubmed: 18239614
J Invest Dermatol. 2010 Apr;130(4):1005-12
pubmed: 20072134
Cell Adh Migr. 2012 Jan-Feb;6(1):20-9
pubmed: 22647937
Gynecol Oncol. 2018 Mar;148(3):567-575
pubmed: 29329880
Eur J Clin Invest. 2019 Feb;49(2):e13047
pubmed: 30412664
Immunobiology. 2008;213(9-10):729-32
pubmed: 18926288
Semin Respir Crit Care Med. 2018 Aug;39(4):494-503
pubmed: 30404116
Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14022-7
pubmed: 16172402
J Immunol. 2017 May 15;198(10):3775-3789
pubmed: 28483986
J Rheumatol. 1996 Aug;23(8):1338-44
pubmed: 8856611
J Biol Chem. 2000 Aug 25;275(34):26566-75
pubmed: 10858439
Blood Adv. 2018 Apr 10;2(7):731-744
pubmed: 29592875
Nat Commun. 2017 May 30;8:15559
pubmed: 28555620
J Immunol Methods. 2015 Nov;426:120-7
pubmed: 26342259
Front Immunol. 2018 Nov 15;9:2650
pubmed: 30524429
Hepatology. 2015 Nov;62(5):1563-75
pubmed: 26207521
Int J Biol Sci. 2015 Sep 11;11(11):1269-71
pubmed: 26435692
Blood. 2016 Nov 3;128(18):2261-2263
pubmed: 27629550
J Immunol. 2005 Dec 15;175(12):7889-97
pubmed: 16339524
Nat Commun. 2014 Oct 28;5:5359
pubmed: 25348463
J Exp Med. 2003 Aug 4;198(3):469-74
pubmed: 12885870
Cytokine Growth Factor Rev. 2019 Aug;48:24-31
pubmed: 31296363
Stem Cells Int. 2019 Jul 1;2019:4848279
pubmed: 31354839
Connect Tissue Res. 2018 Mar;59(2):99-107
pubmed: 28324674
PLoS One. 2015 Sep 25;10(9):e0138872
pubmed: 26405763
J Immunol. 2013 Mar 15;190(6):2544-53
pubmed: 23418628
Front Immunol. 2018 Nov 20;9:2655
pubmed: 30515156
Cell Immunol. 2017 Nov;321:40-45
pubmed: 28756897
Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):6434-6439
pubmed: 29866844
J Immunol. 2011 Jun 1;186(11):6227-37
pubmed: 21525391
J Immunol. 2014 Nov 1;193(9):4712-21
pubmed: 25261488
Int Immunol. 2017 Jul 1;29(7):327-335
pubmed: 28910968
Blood. 2014 Jul 24;124(4):590-7
pubmed: 24948657
Nat Immunol. 2016 May;17(5):545-55
pubmed: 27019226
Front Immunol. 2019 May 14;10:1068
pubmed: 31139190
J Immunol. 2017 Mar 1;198(5):1944-1951
pubmed: 28100681
J Immunol. 2013 Aug 1;191(3):1496-504
pubmed: 23804711
Biochemistry. 2015 Feb 17;54(6):1408-20
pubmed: 25613106
Cell Biochem Biophys. 2016 Dec;74(4):553-558
pubmed: 27718044
Sci Transl Med. 2014 Mar 26;6(229):229ra40
pubmed: 24670684
Infect Immun. 2005 Nov;73(11):7637-43
pubmed: 16239568
Sci Signal. 2017 Aug 22;10(493):
pubmed: 28831022
Immunology. 2011 Aug;133(4):420-5
pubmed: 21631496
J Immunol. 1999 Jul 15;163(2):995-9
pubmed: 10395697
Lupus. 2013 Jun;22(7):657-63
pubmed: 23753600
Parasite Immunol. 2013 Dec;35(12):409-20
pubmed: 23834512
Immunol Rev. 2016 Sep;273(1):299-311
pubmed: 27558342
J Cell Sci. 2006 Oct 1;119(Pt 19):3901-3
pubmed: 16988024
J Leukoc Biol. 2007 Jun;81(6):1395-403
pubmed: 17389580
Growth Factors. 2005 Mar;23(1):33-41
pubmed: 16019425
Eur J Clin Invest. 2018 Nov;48 Suppl 2:e12939
pubmed: 29682742
Cancer Res. 2008 Oct 15;68(20):8429-36
pubmed: 18922916
Immunity. 1996 Dec;5(6):653-66
pubmed: 8986723
Front Immunol. 2012 May 25;3:127
pubmed: 22654882
J Autoimmun. 2018 Jan;86:19-28
pubmed: 29066026
Curr Opin Rheumatol. 2019 Mar;31(2):185-192
pubmed: 30672908
Cancer Immunol Res. 2017 Jan;5(1):3-8
pubmed: 28052991
Immunobiology. 2019 Dec 3;:151884
pubmed: 31822435
Infect Immun. 2003 Oct;71(10):5986-93
pubmed: 14500519
PLoS One. 2017 Dec 15;12(12):e0189545
pubmed: 29244882
J Cell Sci. 2016 Jan 1;129(1):17-27
pubmed: 26729028
J Clin Invest. 2017 Apr 3;127(4):1271-1283
pubmed: 28263189
Cytokine Growth Factor Rev. 2015 Oct;26(5):559-68
pubmed: 26182974
Wound Repair Regen. 2007 Jul-Aug;15(4):566-71
pubmed: 17650101
Cell Signal. 2014 Jul;26(7):1489-99
pubmed: 24662262
J Immunol. 2011 Mar 1;186(5):2998-3005
pubmed: 21270398
J Immunol. 2004 Jul 1;173(1):297-306
pubmed: 15210787
J Leukoc Biol. 2016 May;99(5):699-710
pubmed: 26590149
Front Immunol. 2018 May 24;9:1128
pubmed: 29881383
Adv Biol Regul. 2017 Jan;63:107-114
pubmed: 27720134
J Cell Biol. 2016 Nov 7;215(3):383-399
pubmed: 27799367
Oncoimmunology. 2018 Sep 6;7(12):e1500674
pubmed: 30524895
Mol Cell Biol. 2017 Mar 17;37(7):
pubmed: 28052935
Sci Rep. 2015 Nov 03;5:15948
pubmed: 26526388
Hum Pathol. 2014 Feb;45(2):285-93
pubmed: 24331841
Exp Mol Med. 2018 Feb 5;50(2):e439
pubmed: 29400702
Front Immunol. 2016 Nov 23;7:520
pubmed: 27933060
J Neurovirol. 2015 Dec;21(6):614-22
pubmed: 25740538
Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):3403-3408
pubmed: 28292891
Glia. 2012 May;60(6):993-1003
pubmed: 22438044
J Biol Chem. 2018 May 4;293(18):6869-6882
pubmed: 29540475
Semin Cell Dev Biol. 2019 May;89:47-57
pubmed: 29601861
Blood. 2003 Jan 15;101(2):611-20
pubmed: 12393562
Acta Derm Venereol. 1999 Mar;79(2):105-10
pubmed: 10228626
Biochem J. 2009 Mar 15;418(3):491-506
pubmed: 19228122
Circulation. 2008 Apr 15;117(15):1997-2008
pubmed: 18378617
Eur J Immunol. 2016 Aug;46(8):1887-901
pubmed: 27188212
Rheumatol Int. 2015 May;35(5):815-23
pubmed: 25315704
Biol Cell. 2012 Nov;104(11):631-40
pubmed: 22804617
J Immunol. 2017 Aug 1;199(3):874-884
pubmed: 28637901
J Immunol. 2003 Oct 15;171(8):3970-6
pubmed: 14530315
Pediatr Allergy Immunol. 2016 Mar;27(2):214-7
pubmed: 26359933
Front Med (Lausanne). 2014 Nov 12;1:45
pubmed: 25593918
Eur J Immunol. 2011 Jul;41(7):2074-85
pubmed: 21480213
Cancers (Basel). 2019 Jul 23;11(7):
pubmed: 31340499
Immunity. 2016 Dec 20;45(6):1311-1326
pubmed: 28002731
Trends Cell Biol. 2017 Apr;27(4):241-254
pubmed: 27986534
Cell Mol Life Sci. 2015 Feb;72(3):537-556
pubmed: 25355055
J Immunol. 2012 Jun 1;188(11):5293-302
pubmed: 22551553
Biochem Biophys Res Commun. 2017 Nov 4;493(1):528-533
pubmed: 28867190
Neurology. 2017 Mar 21;88(12):1197-1205
pubmed: 28228564
J Immunol. 2017 Jan 15;198(2):708-717
pubmed: 27986909
Clin Exp Immunol. 2016 Sep;185(3):361-71
pubmed: 27118513
J Immunol. 2002 Jan 1;168(1):308-15
pubmed: 11751975
Front Cell Dev Biol. 2018 Sep 19;6:116
pubmed: 30283780
Int J Biochem Cell Biol. 2015 Oct;67:92-100
pubmed: 26043891
J Immunol Res. 2014;2014:476068
pubmed: 24741603
Eur J Clin Invest. 2018 Nov;48 Suppl 2:e12966
pubmed: 29896791
Biochem Soc Trans. 2017 Aug 15;45(4):999-1006
pubmed: 28710286
J Hematol Oncol. 2019 Jul 12;12(1):76
pubmed: 31300030
Pediatr Res. 2001 Apr;49(4):537-42
pubmed: 11264438
Ann Oncol. 2017 Dec 1;28(suppl_12):xii18-xii32
pubmed: 29045511
J Cell Biol. 2015 Feb 16;208(4):457-73
pubmed: 25666808
Front Immunol. 2019 Jul 17;10:1602
pubmed: 31379822
Front Immunol. 2018 May 03;9:952
pubmed: 29774029
Curr Opin Struct Biol. 2003 Apr;13(2):236-43
pubmed: 12727518
BMB Rep. 2015 Jul;48(7):369-70
pubmed: 26129675
J Leukoc Biol. 2017 Sep;102(3):677-683
pubmed: 28292945
J Immunol. 2016 Feb 1;196(3):1272-83
pubmed: 26718340
J Cell Sci. 2019 Oct 16;133(5):
pubmed: 31471459
J Virol. 2011 Oct;85(19):9945-55
pubmed: 21775452
Mol Immunol. 2012 Jul;51(3-4):255-62
pubmed: 22463790
Immunobiology. 2013 Jan;218(1):28-39
pubmed: 22445076
Shock. 2014 Dec;42(6):532-9
pubmed: 25075642
J Immunol. 2011 Sep 1;187(5):2702-10
pubmed: 21795599
J Dermatol Sci. 1998 Jan;16(2):135-43
pubmed: 9459126
Malar J. 2016 Jul 30;15(1):393
pubmed: 27473068
Int Immunol. 2008 Sep;20(9):1119-27
pubmed: 18644832
J Immunol. 2010 Apr 1;184(7):3917-26
pubmed: 20190141
Blood. 2007 Jan 15;109(2):661-9
pubmed: 17003381
Front Immunol. 2018 Jan 18;9:25
pubmed: 29403502
Br J Pharmacol. 2011 Oct;164(4):1079-106
pubmed: 21371012
Curr Opin Hematol. 2013 Jan;20(1):16-25
pubmed: 23207660
J Biol Chem. 2008 Nov 21;283(47):32704-14
pubmed: 18820259
Eur J Immunol. 2006 Oct;36(10):2781-94
pubmed: 16981228
Haematologica. 2014 Jul;99(7):1138-48
pubmed: 24986876
J Invest Dermatol. 2008 Nov;128(11):2615-24
pubmed: 18496564
Front Immunol. 2018 Sep 12;9:2084
pubmed: 30258446
Structure. 2018 Aug 7;26(8):1080-1090.e5
pubmed: 29937357
Hepatology. 2009 Nov;50(5):1606-16
pubmed: 19821527
Cells. 2019 May 16;8(5):
pubmed: 31100864
Front Cell Dev Biol. 2017 Mar 07;5:18
pubmed: 28326306
Blood. 2014 Jun 26;123(26):4101-10
pubmed: 24829201
Biochim Biophys Acta. 2016 Mar;1863(3):427-437
pubmed: 26264495
Curr Opin Hematol. 2017 Jan;24(1):38-45
pubmed: 27749372
Curr Biol. 2017 Jul 10;27(13):1956-1967.e7
pubmed: 28625781
J Dtsch Dermatol Ges. 2009 Jan;7(1):5
pubmed: 19138293
Sci Rep. 2015 Jan 16;5:7834
pubmed: 25592296
Blood. 2006 Feb 1;107(3):1063-9
pubmed: 16234355
J Biol Chem. 2014 Jul 11;289(28):19420-34
pubmed: 24872409
Nature. 2017 Apr 27;544(7651):493-497
pubmed: 28424516
Blood. 2011 Jun 30;117(26):7042-52
pubmed: 21536861
Sci Rep. 2018 Jan 17;8(1):885
pubmed: 29343807
J Immunol. 1993 Aug 1;151(3):1571-8
pubmed: 8101543
Front Immunol. 2015 Jan 12;5:671
pubmed: 25628621
Drug Des Devel Ther. 2017 Dec 22;12:25-40
pubmed: 29317800
Front Immunol. 2015 Nov 18;6:575
pubmed: 26635791
J Immunol. 2010 Dec 1;185(11):7057-66
pubmed: 21037096
J Int Med Res. 2018 Mar;46(3):1008-1014
pubmed: 29207897
Gastroenterology. 2001 Oct;121(4):958-64
pubmed: 11606509
Cell Mol Life Sci. 2018 Nov;75(22):4177-4185
pubmed: 30206641
Annu Rev Med. 2010;61:35-47
pubmed: 19719397
Cancer Immunol Res. 2014 Nov;2(11):1023-33
pubmed: 25367977
Blood. 2010 Sep 16;116(11):1885-94
pubmed: 20530790
J Cell Biol. 2016 Dec 19;215(6):875-889
pubmed: 27903610
Immunol Lett. 2012 Feb 29;142(1-2):1-13
pubmed: 22207038
Genes Dis. 2018 Dec 31;6(1):16-24
pubmed: 30906828
Blood. 2011 Mar 10;117(10):2874-82
pubmed: 21239699
J Pediatr Hematol Oncol. 2015 May;37(4):264-8
pubmed: 25072369
Infect Immun. 2009 Dec;77(12):5668-75
pubmed: 19797068
J Med Chem. 2006 Nov 30;49(24):6946-9
pubmed: 17125246
Nat Commun. 2016 Jul 22;7:12242
pubmed: 27447355
J Autoimmun. 2018 Nov;94:45-55
pubmed: 30054208
J Infect Dis. 1985 Oct;152(4):668-89
pubmed: 3900232
Annu Rev Phytopathol. 2017 Aug 4;55:109-137
pubmed: 28525309
Cytokine. 2020 Mar;127:154939
pubmed: 31786501
Front Immunol. 2017 Apr 21;8:461
pubmed: 28484459
J Immunol. 2007 Aug 15;179(4):2359-67
pubmed: 17675497
Biochim Biophys Acta. 2009 Apr;1788(4):779-89
pubmed: 19161977
J Exp Med. 1997 Dec 1;186(11):1853-63
pubmed: 9382884
Sci Signal. 2017 Aug 08;10(491):
pubmed: 28790195
J Immunol. 2003 Jul 15;171(2):584-93
pubmed: 12847222
Front Immunol. 2018 May 29;9:1182
pubmed: 29896200
Crit Rev Immunol. 2017;37(2-6):463-481
pubmed: 29773030
Curr Opin Cell Biol. 2012 Oct;24(5):670-6
pubmed: 22770729
Exp Cell Res. 2005 Nov 1;310(2):282-92
pubmed: 16154563
J Immunol. 1999 Nov 1;163(9):5029-38
pubmed: 10528208
Immunol Cell Biol. 2016 Nov;94(10):981-993
pubmed: 27359298
Semin Immunopathol. 2018 Nov;40(6):577-591
pubmed: 30306257
J Invest Dermatol. 2010 Mar;130(3):743-54
pubmed: 19812597
Swiss Med Wkly. 2016 Feb 22;146:w14281
pubmed: 26901377
Nat Rev Microbiol. 2018 Jan;16(1):32-46
pubmed: 29176582
J Immunol. 2000 Sep 1;165(5):2596-602
pubmed: 10946287
BMC Cancer. 2016 Jul 11;16:440
pubmed: 27400708
J Immunol. 2001 Jan 1;166(1):574-81
pubmed: 11123339
Nat Rev Immunol. 2017 May;17(5):306-321
pubmed: 28317925
Immunol Cell Biol. 2016 May;94(5):486-95
pubmed: 26740009
J Surg Res. 2014 Jan;186(1):192-200
pubmed: 24120241
Front Immunol. 2016 Sep 19;7:363
pubmed: 27698655
Curr Opin Hematol. 2016 Jan;23(1):36-43
pubmed: 26554893
J Immunol. 2017 Jun 15;198(12):4855-4867
pubmed: 28500072
Exp Cell Res. 2005 Mar 10;304(1):116-26
pubmed: 15707579
Cell. 2007 Jan 12;128(1):171-82
pubmed: 17218263
Infect Immun. 2014 May;82(5):1766-77
pubmed: 24549323
J Cell Sci. 2005 Nov 15;118(Pt 22):5205-20
pubmed: 16249234
J Immunol. 1993 Apr 1;150(7):3030-41
pubmed: 7681086
Neurology. 2012 Feb 14;78(7):458-67; discussion 465
pubmed: 22302546
Cell. 2011 Nov 11;147(4):868-80
pubmed: 22078883
J Immunol. 2014 Sep 15;193(6):2863-72
pubmed: 25108025
Physiol Genomics. 2005 Apr 14;21(2):230-42
pubmed: 15831844
Oncotarget. 2015 Sep 29;6(29):27478-89
pubmed: 26317647
Blood. 2001 Apr 15;97(8):2478-86
pubmed: 11290613
Trends Parasitol. 2015 Dec;31(12):653-664
pubmed: 26440786
Sci Signal. 2014 Jul 29;7(336):ra72
pubmed: 25074980
Nat Commun. 2014;5:3039
pubmed: 24423728