Genetic history from the Middle Neolithic to present on the Mediterranean island of Sardinia.

Archaeology / methods Body Remains Chromosomes, Human, X / genetics Chromosomes, Human, Y / genetics DNA, Ancient DNA, Mitochondrial / genetics Datasets as Topic Female Genetics, Population / history History, 15th Century History, 16th Century History, 17th Century History, 18th Century History, 19th Century History, 20th Century History, 21st Century History, Ancient History, Medieval Human Migration Humans Italy Male Models, Genetic Sequence Analysis, DNA

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
24 02 2020
Historique:
received: 21 03 2019
accepted: 08 01 2020
entrez: 26 2 2020
pubmed: 26 2 2020
medline: 6 5 2020
Statut: epublish

Résumé

The island of Sardinia has been of particular interest to geneticists for decades. The current model for Sardinia's genetic history describes the island as harboring a founder population that was established largely from the Neolithic peoples of southern Europe and remained isolated from later Bronze Age expansions on the mainland. To evaluate this model, we generate genome-wide ancient DNA data for 70 individuals from 21 Sardinian archaeological sites spanning the Middle Neolithic through the Medieval period. The earliest individuals show a strong affinity to western Mediterranean Neolithic populations, followed by an extended period of genetic continuity on the island through the Nuragic period (second millennium BCE). Beginning with individuals from Phoenician/Punic sites (first millennium BCE), we observe spatially-varying signals of admixture with sources principally from the eastern and northern Mediterranean. Overall, our analysis sheds light on the genetic history of Sardinia, revealing how relationships to mainland populations shifted over time.

Identifiants

DOI: 10.1038/s41467-020-14523-6 PMID: 32094358 PMC: PMC7039977
pubmed: 32094358
doi: 10.1038/s41467-020-14523-6
pii: 10.1038/s41467-020-14523-6
pmc: PMC7039977
doi:

Substances chimiques

DNA, Ancient 0
DNA, Mitochondrial 0

Types de publication

Historical Article Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

939

Références

Keller, A. et al. New insights into the Tyrolean Iceman’s origin and phenotype as inferred by whole-genome sequencing. Nat. Commun. 3, 698 (2012).
doi: 10.1038/ncomms1701 pubmed: 22426219 pmcid: 22426219
Sikora, M. et al. Population genomic analysis of ancient and modern genomes yields new insights into the genetic ancestry of the Tyrolean Iceman and the genetic structure of Europe. PLoS Genet. 10, e1004353 (2014).
doi: 10.1371/journal.pgen.1004353 pubmed: 24809476 pmcid: 24809476
Skoglund, P. et al. Origins and genetic legacy of Neolithic farmers and hunter-gatherers in Europe. Science 336, 466–469 (2012).
doi: 10.1126/science.1216304 pubmed: 22539720 pmcid: 22539720
Skoglund, P. et al. Genomic diversity and admixture differs for Stone-Age Scandinavian foragers and farmers. Science 344, 747–750 (2014).
doi: 10.1126/science.1253448 pubmed: 24762536 pmcid: 24762536
Gamba, C. et al. Genome flux and stasis in a five millennium transect of European prehistory. Nat. Commun. 5, 5257 (2014).
doi: 10.1038/ncomms6257 pubmed: 25334030 pmcid: 25334030
Olalde, I. et al. A common genetic origin for early farmers from Mediterranean Cardial and Central European LBK cultures. Mol. Biol. Evolution 32, 3132–3142 (2015).
Lazaridis, I. et al. Ancient human genomes suggest three ancestral populations for present-day Europeans. Nature 513, 409–413 (2014).
doi: 10.1038/nature13673 pubmed: 4170574 pmcid: 4170574
Hofmanová, Z. et al. Early farmers from across Europe directly descended from Neolithic Aegeans. Proc. Natl Acad. Sci. 113, 6886–6891 (2016).
doi: 10.1073/pnas.1523951113
Mathieson, I. et al. The genomic history of southeastern Europe. Nature 555, 197 (2018).
doi: 10.1038/nature25778 pubmed: 29466330 pmcid: 29466330
Lipson, M. et al. Parallel palaeogenomic transects reveal complex genetic history of early European farmers. Nature 551, 368–372 (2017).
doi: 10.1038/nature24476 pubmed: 29144465 pmcid: 29144465
Allentoft, M. E. et al. Population genomics of Bronze Age Eurasia. Nature 522, 167–172 (2015).
doi: 10.1038/nature14507 pubmed: 26062507 pmcid: 26062507
Haak, W. et al. Massive migration from the steppe was a source for Indo-European languages in Europe. Nature 522, 207–211 (2015).
doi: 10.1038/nature14317 pubmed: 5048219 pmcid: 5048219
Olalde, I. et al. The Beaker phenomenon and the genomic transformation of Northwest Europe. Nature 555, 190 (2018).
doi: 10.1038/nature25738 pubmed: 29466337 pmcid: 29466337
Olalde, I. et al. The genomic history of the Iberian Peninsula over the past 8000 years. Science 363, 1230–1234 (2019).
doi: 10.1126/science.aav4040 pubmed: 30872528 pmcid: 30872528
Melis, P. Un Approdo della costa di Castelsardo, fra età nuragica e romana (Carocci, 2002).
Lugliè, C. Your path led trough the sea… the emergence of Neolithic in Sardinia and Corsica. Quat. Int. 470, 285–300 (2018).
doi: 10.1016/j.quaint.2017.12.032
Barnett, W. K. Cardial pottery and the agricultural transition in Mediterranean Europe. Europeas First Farmers 93–116 (2000).
Zilhão, J. Radiocarbon evidence for maritime pioneer colonization at the origins of farming in west Mediterranean Europe. Proc. Natl Acad. Sci. USA 98, 14180–14185 (2001).
doi: 10.1073/pnas.241522898
Tykot, R. H. Obsidian procurement and distribution in the central and western Mediterranean. J. Mediterranean Archaeol. 9, 39–82 (1996).
doi: 10.1558/jmea.v9i1.39
Webster, G. The Archaeology of Nuragic Sardinia, vol. 14 of Monographs in Mediterranean Archaeology (Equinox Publishing, 2016).
Moscati, S. La penetrazione fenicia e punica in Sardegna. Mem. della Accad. Nazionale dei Lincei, Cl. di Sci. Moral., storiche e filologiche 8.7.3, 215–250 (1966).
Van Dommelen, P. Punic farms and Carthaginian colonists: surveying Punic rural settlement in the central Mediterranean. J. Rom. Archaeol. 19, 7–28 (2006).
doi: 10.1017/S1047759400006243
Guirguis, M., Murgia, C. & Pla Orquín, R. in From the Mediterranean to the Atlantic: People, Goods and Ideas between East and West. Proceedings of the 8th International Congress of Phoenician and Punic Studies (Italy, Sardinia-Carbonia, Sant’Antioco, 21–26 October 2013) (Folia Phoenicia, 1) (ed Serra, F.) 282–299 (Fabrizio Serra Editore, Pisa-Roma, 2017).
Dyson, S. & Rowland, R. Archaeology and History in Sardinia from the Stone Age to the Middle Ages. Shepherds, Sailors, and Conquerors (University of Pennsylvania Museum Press, 2007).
Ortu, L. Storia della Sardegna dal Medioevo all’età contemporanea (Cuec, 2011).
Mastino, A. Storia della Sardegna antica, Vol. 2 (Il Maestrale, 2005).
Calò, C., Melis, A., Vona, G. & Piras, I. Review synthetic article: Sardinian population (italy): a genetic review. Int. J. Mod. Anthropol. 1, 39–64 (2008).
Lettre, G. & Hirschhorn, J. N. Small island, big genetic discoveries. Nat. Genet. 47, 1224–1225 (2015).
doi: 10.1038/ng.3426
Siniscalco, M. et al. Population genetics of haemoglobin variants, thalassaemia and glucose-6-phosphate dehydrogenase deficiency, with particular reference to the malaria hypothesis. Bull. World Health Organ. 34, 379 (1966).
pubmed: 2475975 pmcid: 2475975
Contu, L., Arras, M., Carcassi, C., Nasa, G. L. & Mulargia, M. HLA structure of the Sardinian population: a haplotype study of 551 families. Tissue Antigens 40, 165–174 (1992).
doi: 10.1111/j.1399-0039.1992.tb02041.x
Lampis, R., Morelli, L., De Virgiliis, S., Congia, M. & Cucca, F. The distribution of HLA class II haplotypes reveals that the Sardinian population is genetically differentiated from the other Caucasian populations. Tissue Antigens 56, 515–521 (2000).
doi: 10.1034/j.1399-0039.2000.560605.x
Chiang, C. W. et al. Genomic history of the Sardinian population. Nat. Genet. 1, 1426–1434 (2018).
doi: 10.1038/s41588-018-0215-8
Sidore, C. et al. Genome sequencing elucidates Sardinian genetic architecture and augments association analyses for lipid and blood inflammatory markers. Nat. Genet. 47, 1272–1281 (2015).
doi: 10.1038/ng.3368 pubmed: 4627508 pmcid: 4627508
Ghirotto, S. et al. Inferring genealogical processes from patterns of Bronze-Age and modern DNA variation in Sardinia. Mol. Biol. Evolution 27, 875–886 (2009).
doi: 10.1093/molbev/msp292
Modi, A. et al. Complete mitochondrial sequences from Mesolithic Sardinia. Sci. Rep. 7, 42869 (2017).
doi: 10.1038/srep42869 pubmed: 5335606 pmcid: 5335606
Olivieri, A. et al. Mitogenome diversity in Sardinians: a genetic window onto an islandas past. Mol. Biol. Evolution 34, 1230–1239 (2017).
doi: 10.1093/molbev/msx082
Matisoo-Smith, E. et al. Ancient mitogenomes of Phoenicians from Sardinia and Lebanon: a story of settlement, integration, and female mobility. PloS ONE 13, e0190169 (2018).
doi: 10.1371/journal.pone.0190169 pubmed: 5761892 pmcid: 5761892
Viganó, C., Haas, C., Rühli, F. J. & Bouwman, A. 2000 year old β -thalassemia case in Sardinia suggests malaria was endemic by the Roman period. Am. J. Phys. Anthropol. 164, 362–370 (2017).
doi: 10.1002/ajpa.23278
Pickrell, J. K. & Reich, D. Toward a new history and geography of human genes informed by ancient DNA. Trends Genet. 30, 377–389 (2014).
doi: 10.1016/j.tig.2014.07.007 pubmed: 4163019 pmcid: 4163019
Lai, L. et al. Diet in the Sardinian Bronze Age: models, collagen isotopic data, issues and perspectives. Préhistoires Méditerranéennes (2013).
Skeates, R., Gradoli, M. G. & Beckett, J. The cultural life of caves in Seulo, central Sardinia. J. Mediterranean Archaeol. 26, 97–126 (2013).
doi: 10.1558/jmea.v26i1.97
Germanà, F. in Atti del XX Congresso Internazionale d’Antropologia e d’Archeologia Preistorica, Cagliari, Poligraf, Aprilia, 377–394 (Università di Cagliari, 1980).
Pompianu, E. & Murgia, C. in Sa Massarìa: ecologia storica dei sistemi di lavoro contadino in Sardegna. (Europa e Mediterraneo. Storia e immagini di una comunità internazionale 37) (eds Serreli, G., Melis, R., French, C. & Sulas, F.) 455–504 (CNR, Cagliari, 2017).
La Fragola, A. & Rovina, D. Il cimitero romano di Monte Carru (Alghero) e la statio di Carbia. Sard., Cors. et. Baleares antiquae 16, 59–79 (2018).
Meloni, G. M. in Bonnanaro e il suo patrimonio culturale (ed Conca, C.) 90–99 (Segnavia, Sassari, 2004).
Rovina, D., Fiori, M. & Olia, P. in Sassari: Archeologia Urbana (eds Rovina, D., Fiori, M.) 120–129 (Felici Editore, 2013).
Fu, Q. et al. An early modern human from Romania with a recent Neanderthal ancestor. Nature 524, 216 (2015).
doi: 10.1038/nature14558 pubmed: 4537386 pmcid: 4537386
Mathieson, I. et al. Genome-wide patterns of selection in 230 ancient Eurasians. Nature 528, 499–503 (2015).
doi: 10.1038/nature16152 pubmed: 4918750 pmcid: 4918750
Lazaridis, I. et al. Genomic insights into the origin of farming in the ancient Near East. Nature 536, 419–424 (2016).
doi: 10.1038/nature19310 pubmed: 27459054 pmcid: 27459054
Lazaridis, I. et al. Genetic origins of the Minoans and Mycenaeans. Nature 548, 214–218 (2017).
doi: 10.1038/nature23310 pubmed: 28783727 pmcid: 28783727
Francalacci, P. et al. Low-pass DNA sequencing of 1200 Sardinians reconstructs European Y-chromosome phylogeny. Science 341, 565–569 (2013).
doi: 10.1126/science.1237947 pubmed: 5500864 pmcid: 5500864
Fernandes, D. M. et al. The arrival of Steppe and Iranian related ancestry in the islands of the Western Mediterranean. bioRxiv https://doi.org/10.1101/584714 (2019).
Feldman, M. et al. Ancient DNA sheds light on the genetic origins of early Iron Age Philistines. Sci. Adv. 5, eaax0061 (2019).
doi: 10.1126/sciadv.aax0061 pubmed: 6609216 pmcid: 6609216
Antonio, M. L. et al. Ancient Rome: a genetic crossroads of Europe and the Mediterranean. Science 366, 708–714 (2019).
doi: 10.1126/science.aay6826
Le Lannou, M. et al. Pâtres et Paysans de la Sardaigne. Tours 8, 364 (1941).
Sarno, S. et al. Ancient and recent admixture layers in Sicily and Southern Italy trace multiple migration routes along the Mediterranean. Sci. Rep. 7, 1984 (2017).
doi: 10.1038/s41598-017-01802-4 pubmed: 28512355 pmcid: 28512355
Günther, T. et al. Ancient genomes link early farmers from atapuerca in spain to modern-day basques. Proc. Natl Acad. Sci. USA 112, 11917–11922 (2015).
doi: 10.1073/pnas.1509851112
Zalloua, P. et al. Ancient DNA of Phoenician remains indicates discontinuity in the settlement history of Ibiza. Sci. Rep. 8, 17567 (2018).
doi: 10.1038/s41598-018-35667-y pubmed: 30514893 pmcid: 30514893
Hellenthal, G. et al. A genetic atlas of human admixture history. Science 343, 747–751 (2014).
doi: 10.1126/science.1243518 pubmed: 24531965 pmcid: 24531965
Loh, P.-R. et al. Inferring admixture histories of human populations using linkage disequilibrium. Genetics 193, 1233–1254 (2013).
doi: 10.1534/genetics.112.147330 pubmed: 23410830 pmcid: 23410830
Dabney, J. et al. Complete mitochondrial genome sequence of a middle pleistocene cave bear reconstructed from ultrashort DNA fragments. Proc. Natl Acad. Sci. USA 110, 15758–15763 (2013).
Meyer, M. & Kircher, M. Illumina sequencing library preparation for highly multiplexed target capture and sequencing. Cold Spring Harb. Protoc. 2010, pdb–prot5448 (2010).
doi: 10.1101/pdb.prot5448
Rohland, N., Harney, E., Mallick, S., Nordenfelt, S. & Reich, D. Partial uracil–DNA–glycosylase treatment for screening of ancient DNA. Philos. Trans. R. Soc. B: Biol. Sci. 370, 20130624 (2015).
doi: 10.1098/rstb.2013.0624
Peltzer, A. et al. Eager: efficient ancient genome reconstruction. Genome Biol. 17, 60 (2016).
doi: 10.1186/s13059-016-0918-z pubmed: 4815194 pmcid: 4815194
Schubert, M., Lindgreen, S. & Orlando, L. Adapterremoval v2: rapid adapter trimming, identification, and read merging. BMC Res. Notes 9, 88 (2016).
doi: 10.1186/s13104-016-1900-2 pubmed: 4751634 pmcid: 4751634
Li, H. & Durbin, R. Fast and accurate short read alignment with burrows–wheeler transform. Bioinformatics 25, 1754–1760 (2009).
doi: 10.1093/bioinformatics/btp324 pubmed: 2705234 pmcid: 2705234
Korneliussen, T. S., Albrechtsen, A. & Nielsen, R. ANGSD: analysis of next generation sequencing data. BMC Bioinforma. 15, 356 (2014).
doi: 10.1186/s12859-014-0356-4
Al-Asadi, H., Dey, K. K., Novembre, J. & Stephens, M. Inference and visualization of DNA damage patterns using a grade of membership model. Bioinformatics 35, 1292–1298 (2018).
doi: 10.1093/bioinformatics/bty779
Renaud, G., Slon, V., Duggan, A. T. & Kelso, J. Schmutzi: estimation of contamination and endogenous mitochondrial consensus calling for ancient DNA. Genome Biol. 16, 224 (2015).
doi: 10.1186/s13059-015-0776-0 pubmed: 4601135 pmcid: 4601135
Vianello, D. et al. Haplofind: a new method for high-throughput mt DNA haplogroup assignment. Hum. Mutat. 34, 1189–1194 (2013).
doi: 10.1002/humu.22356
Andrews, R. M. et al. Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA. Nat. Genet. 23, 147 (1999).
doi: 10.1038/13779
Van Oven, M. & Kayser, M. Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation. Hum. Mutat. 30, E386–E394 (2009).
doi: 10.1002/humu.20921
Patterson, N., Price, A. L. & Reich, D. Population structure and eigenanalysis. PLoS Genet. 2, e190 (2006).
doi: 10.1371/journal.pgen.0020190 pubmed: 1713260 pmcid: 1713260
Lee, S., Zou, F. & Wright, F. A. Convergence and prediction of principal component scores in high-dimensional settings. Ann. Stat. 38, 3605 (2010).
doi: 10.1214/10-AOS821 pubmed: 3062912 pmcid: 3062912
Alexander, D. H., Novembre, J. & Lange, K. Fast model-based estimation of ancestry in unrelated individuals. Genome Res. 19, 1655–1664 (2009).
doi: 10.1101/gr.094052.109 pubmed: 19648217 pmcid: 19648217
Pritchard, J. K., Stephens, M. & Donnelly, P. Inference of population structure using multilocus genotype data. Genetics 155, 945–959 (2000).
pubmed: 1461096 pmcid: 1461096
Patterson, N. et al. Ancient admixture in human history. Genetics 192, 1065–1093 (2012).
doi: 10.1534/genetics.112.145037 pubmed: 22960212 pmcid: 22960212
1000 Genomes Project Consortium. A global reference for human genetic variation. Nature 526, 68 (2015).
doi: 10.1038/nature15393

Auteurs

Joseph H Marcus (JH)

Department of Human Genetics, University of Chicago, Chicago, IL, USA.
ORCID: 0000-0002-0923-9881

Cosimo Posth (C)

Max Planck Institute for the Science of Human History, Jena, Germany.
Institute for Archaeological Sciences, University of Tübingen, Tübingen, Germany.
ORCID: 0000-0002-8206-3907

Harald Ringbauer (H)

Department of Human Genetics, University of Chicago, Chicago, IL, USA.
ORCID: 0000-0002-4884-9682

Luca Lai (L)

Department of Anthropology, University of South Florida, Tampa, FL, USA.
Department of Anthropology, University of North Carolina at Charlotte, Charlotte, NC, USA.

Robin Skeates (R)

Department of Archaeology, Durham University, Durham, UK.

Carlo Sidore (C)

Istituto di Ricerca Genetica e Biomedica - CNR, Cagliari, Italy.
Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy.
ORCID: 0000-0001-7504-7477

Jessica Beckett (J)

Private contractor, Cagliari, Sardinia, Italy.

Anja Furtwängler (A)

Institute for Archaeological Sciences, University of Tübingen, Tübingen, Germany.

Anna Olivieri (A)

Dipartimento di Biologia e Biotecnologie "L. Spallanzani", Università di Pavia, Pavia, Italy.
ORCID: 0000-0002-3941-8098

Charleston W K Chiang (CWK)

Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Quantitative and Computational Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.
ORCID: 0000-0002-0668-7865

Hussein Al-Asadi (H)

Department of Statistics, University of Chicago, Chicago, IL, USA.
Committee on Evolutionary Biology, University of Chicago, Chicago, IL, USA.

Kushal Dey (K)

Department of Statistics, University of Chicago, Chicago, IL, USA.
Department of Epidemiology, Harvard School of Public Health, Boston, MA, 02115, USA.

Tyler A Joseph (TA)

Department of Computer Science, Columbia University, New York, NY, USA.

Chi-Chun Liu (CC)

Department of Human Genetics, University of Chicago, Chicago, IL, USA.

Clio Der Sarkissian (C)

Laboratoire d'Anthropologie Moléculaire et d'Imagerie de Synthèse, CNRS UMR 5288, Université de Toulouse 3, Toulouse, France.

Rita Radzevičiūtė (R)

Max Planck Institute for the Science of Human History, Jena, Germany.

Megan Michel (M)

Max Planck Institute for the Science of Human History, Jena, Germany.
Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, 02138, USA.

Maria Giuseppina Gradoli (MG)

School of Archaeology and Ancient History, University of Leicester, Leicester, UK.

Patrizia Marongiu (P)

Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy.

Salvatore Rubino (S)

Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy.

Vittorio Mazzarello (V)

Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy.

Daniela Rovina (D)

Soprintendenza Archeologia, belle arti e paesaggio delle province di Sassari e Nuoro, Sassari, Italy.

Alessandra La Fragola (A)

Departamento de Geografía, Historia y Humanidades Escuela Internacional de Doctorado de la Universidad de Almería, Almería, Spain.

Rita Maria Serra (RM)

Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy.
Center for Anthropological, Paleopathological and Historical Studies of the Sardinian and Mediterranean Populations, University of Sassari, Sassari, Italy.

Pasquale Bandiera (P)

Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy.
Center for Anthropological, Paleopathological and Historical Studies of the Sardinian and Mediterranean Populations, University of Sassari, Sassari, Italy.
ORCID: 0000-0002-0589-4539

Raffaella Bianucci (R)

Department of Sciences and Technological Innovation, University of Eastern Piedmont, 15121, Alessandria, Italy.
Legal Medicine Section, Department of Public Health and Paediatric Sciences, University of Turin, 10126, Turin, Italy.

Elisa Pompianu (E)

Department of History, Human Sciences and Education, University of Sassari, 07100, Sassari, Italy.

Clizia Murgia (C)

Universitat Autònoma de Barcelona, Departament de Biologia Animal, Biologia Vegetal i Ecologia, 08193, Barcelona, Spain.

Michele Guirguis (M)

Department of History, Human Sciences and Education, University of Sassari, 07100, Sassari, Italy.
ORCID: 0000-0001-9222-5124

Rosana Pla Orquin (RP)

Department of History, Human Sciences and Education, University of Sassari, 07100, Sassari, Italy.
ORCID: 0000-0002-6448-015X

Noreen Tuross (N)

Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, 02138, USA.
ORCID: 0000-0002-3080-4005

Peter van Dommelen (P)

Joukowsky Institute for Archaeology and the Ancient World, Brown University, Providence, RI, 02912, USA.
ORCID: 0000-0003-0970-6651

Wolfgang Haak (W)

Max Planck Institute for the Science of Human History, Jena, Germany.
ORCID: 0000-0003-2475-2007

David Reich (D)

Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA.
Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
Max Planck-Harvard Research Center for the Archaeoscience of the Ancient Mediterranean, Munich, Germany.
ORCID: 0000-0002-7037-5292

David Schlessinger (D)

Laboratory of Genetics, NIA, NIH, Baltimore, MD, USA.

Francesco Cucca (F)

Istituto di Ricerca Genetica e Biomedica - CNR, Cagliari, Italy. fcucca@uniss.it.
Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy. fcucca@uniss.it.

Johannes Krause (J)

Max Planck Institute for the Science of Human History, Jena, Germany. krause@shh.mpg.de.
Institute for Archaeological Sciences, University of Tübingen, Tübingen, Germany. krause@shh.mpg.de.
Max Planck-Harvard Research Center for the Archaeoscience of the Ancient Mediterranean, Munich, Germany. krause@shh.mpg.de.
ORCID: 0000-0001-9144-3920

John Novembre (J)

Department of Human Genetics, University of Chicago, Chicago, IL, USA. jnovembre@uchicago.edu.
Department of Ecology and Evolution, University of Chicago, Chicago, IL, USA. jnovembre@uchicago.edu.
ORCID: 0000-0001-5345-0214

Articles similaires

Comprehensive comparative analysis and development of molecular markers for Lasianthus species based on complete chloroplast genome sequences.

Yue Zhang, Meifang Song, Deying Tang et al.
1.00
Genome, Chloroplast Phylogeny Genetic Markers Base Composition High-Throughput Nucleotide Sequencing

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Classifications MeSH

questionsmedicales.fr › Sciences sociales › Anthropologie › Anthropologie culturelle › Archéologie › Genetic history from the Middle Neolithic to...
questionsmedicales.fr › Sciences sociales › Criminologie › Sciences légales › Médecine légale › Restes de corps › Genetic history from the Middle Neolithic to...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Chromosomes › Chromosomes sexuels › Chromosome X › Chromosomes X humains › Genetic history from the Middle Neolithic to...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Chromosomes › Chromosomes sexuels › Chromosome Y › Chromosomes Y humains › Genetic history from the Middle Neolithic to...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN ancien › Genetic history from the Middle Neolithic to...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN mitochondrial › Genetic history from the Middle Neolithic to...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Jeux de données comme sujet › Genetic history from the Middle Neolithic to...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génétique des populations › Genetic history from the Middle Neolithic to...
questionsmedicales.fr › Sciences humaines › Histoire › Histoire prémoderne (1451-1600) › Histoire du 15ème siècle › Genetic history from the Middle Neolithic to...
questionsmedicales.fr › Sciences humaines › Histoire › Histoire prémoderne (1451-1600) › Histoire du 16ème siècle › Genetic history from the Middle Neolithic to...
questionsmedicales.fr › Sciences humaines › Histoire › Histoire moderne 1601- › Histoire du 17ème siècle › Genetic history from the Middle Neolithic to...
questionsmedicales.fr › Sciences humaines › Histoire › Histoire moderne 1601- › Histoire du 18ème siècle › Genetic history from the Middle Neolithic to...
questionsmedicales.fr › Sciences humaines › Histoire › Histoire moderne 1601- › Histoire du 19ème siècle › Genetic history from the Middle Neolithic to...
questionsmedicales.fr › Sciences humaines › Histoire › Histoire moderne 1601- › Histoire du 20ème siècle › Genetic history from the Middle Neolithic to...
questionsmedicales.fr › Sciences humaines › Histoire › Histoire moderne 1601- › Histoire du 21ème siècle › Genetic history from the Middle Neolithic to...
questionsmedicales.fr › Sciences humaines › Histoire › Histoire ancienne › Genetic history from the Middle Neolithic to...
questionsmedicales.fr › Sciences humaines › Histoire › Histoire médiévale › Genetic history from the Middle Neolithic to...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › Dynamique des populations › Migration humaine › Genetic history from the Middle Neolithic to...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genetic history from the Middle Neolithic to...
questionsmedicales.fr › Régions géographiques › Europe › Italie › Genetic history from the Middle Neolithic to...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles génétiques › Genetic history from the Middle Neolithic to...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Genetic history from the Middle Neolithic to...