The Sweet and Sour Taste of Phosphoinositide Signaling: Protonation of PI4P Modulates Its Function in Response to Cytoplasmic pH Changes.

Hydrogen-Ion Concentration Phosphatidylinositol Phosphates Phosphatidylinositols Protein Transport Taste

Journal

Developmental cell
ISSN: 1878-1551
Titre abrégé: Dev Cell
Pays: United States
ID NLM: 101120028

Informations de publication

Date de publication:
24 02 2020
Historique:
entrez: 26 2 2020
pubmed: 26 2 2020
medline: 28 7 2020
Statut: ppublish

Résumé

Phosphoinositides are signaling lipids that recruit effector proteins to membranes. Shin et al. show that a glucose-starvation-induced drop in cytosolic pH alters the protonation state of the phosphoinositide PI4P, resulting in dissociation of its effector Osh1 from the trans-Golgi network membrane and metabolic regulation of lipid and protein sorting.

Identifiants

DOI: 10.1016/j.devcel.2020.01.035 PMID: 32097649
pubmed: 32097649
pii: S1534-5807(20)30067-8
doi: 10.1016/j.devcel.2020.01.035
pii:
doi:

Substances chimiques

Phosphatidylinositol Phosphates 0
Phosphatidylinositols 0

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

395-397

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Oliver Schmidt (O)

Division of Cell Biology, Biocenter, Medical University of Innsbruck, 6020 Innsbruck, Austria. Electronic address: oliver.schmidt@i-med.ac.at.

Maria Bohnert (M)

Institute of Cell Dynamics and Imaging, University of Münster, Von-Esmarch-Str. 56, 48149 Münster, Germany; Cells in Motion Interfaculty Centre (CiM), University of Münster, 48149 Münster, Germany. Electronic address: bohnertm@uni-muenster.de.

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Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Concentration en ions d'hydrogène › The Sweet and Sour Taste of Phosphoinositide...
questionsmedicales.fr › Lipides › Lipides membranaires › Phospholipides › Glycérophosphate › Acides phosphatidiques › Glycérophospholipides › Phosphatidyl inositols › Phosphates phosphatidylinositol › The Sweet and Sour Taste of Phosphoinositide...
questionsmedicales.fr › Lipides › Lipides membranaires › Phospholipides › Glycérophosphate › Acides phosphatidiques › Glycérophospholipides › Phosphatidyl inositols › The Sweet and Sour Taste of Phosphoinositide...
questionsmedicales.fr › Métabolisme › Transport biologique › Transport des protéines › The Sweet and Sour Taste of Phosphoinositide...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sensation › Goût › The Sweet and Sour Taste of Phosphoinositide...