Modulating antibiotic release from reservoirs in 3D-printed orthopedic devices to treat periprosthetic joint infection.
3D printing
elution study
periprosthetic joint infection
revision surgery
total joint arthroplasty
Journal
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
ISSN: 1554-527X
Titre abrégé: J Orthop Res
Pays: United States
ID NLM: 8404726
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
03
07
2019
revised:
28
01
2020
accepted:
19
02
2020
pubmed:
27
2
2020
medline:
15
12
2020
entrez:
27
2
2020
Statut:
ppublish
Résumé
Periprosthetic joint infection is a costly debilitating affliction following total joint arthroplasty. Despite a relatively low incidence rate, periprosthetic joint infection is an increasing problem due to a substantial increase in arthroplasty surgeries over time. The current treatment is replacing the primary implant with a temporary bone cement spacer that releases antibiotics over time. However, the spacer is mechanically weak with an ineffective antibiotic release. Alternatively, three-dimensional (3D)-printed reservoirs in high-strength devices have the potential to release antibiotics long term in a controlled manner. In this study, 3D-printed reservoirs were loaded with calcium sulfate embedded with gentamicin. In vitro antibiotic release is tuned by varying reservoir parameters, such as channel length, diameter, and quantity. In addition, a straightforward computational model effectively predicts antibiotic release curves to rapidly design devices with a preferred release profile. Overall, this study highlights a novel approach to potentially develop high-strength joint implants with the long-term effective release of antibiotics to treat the periprosthetic joint infection.
Substances chimiques
Anti-Bacterial Agents
0
Drug Implants
0
Gentamicins
0
Types de publication
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2239-2249Informations de copyright
© 2020 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
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