Chemical Genetics of AGC-kinases Reveals Shared Targets of Ypk1, Protein Kinase A and Sch9.

Amino Acid Motifs Amino Acid Sequence Consensus Sequence Cyclic AMP-Dependent Protein Kinases / chemistry Phosphorylation / drug effects Protein Kinase Inhibitors / pharmacology Protein Serine-Threonine Kinases / chemistry Proteome / metabolism Saccharomyces cerevisiae / enzymology Saccharomyces cerevisiae Proteins / chemistry Trehalase / metabolism
AGC-kinases Enzyme inhibition cell growth chemical genetics label-free quantification phosphoproteome protein kinases protein motifs trehalase yeast

Journal

Molecular & cellular proteomics : MCP
ISSN: 1535-9484
Titre abrégé: Mol Cell Proteomics
Pays: United States
ID NLM: 101125647

Informations de publication

Date de publication:
04 2020
Historique:
received: 27 01 2020
pubmed: 28 2 2020
medline: 23 1 2021
entrez: 28 2 2020
Statut: ppublish

Résumé

Protein phosphorylation cascades play a central role in the regulation of cell growth and protein kinases PKA, Sch9 and Ypk1 take center stage in regulating this process in

Identifiants

DOI: 10.1074/mcp.RA120.001955 PMID: 32102971 PMC: PMC7124472
pubmed: 32102971
pii: S1535-9476(20)35023-4
doi: 10.1074/mcp.RA120.001955
pmc: PMC7124472
pii:
doi:

Substances chimiques

Protein Kinase Inhibitors 0
Proteome 0
Saccharomyces cerevisiae Proteins 0
Protein Serine-Threonine Kinases EC 2.7.11.1
SCH9 protein, S cerevisiae EC 2.7.11.1
YPK1 protein, S cerevisiae EC 2.7.11.1
Cyclic AMP-Dependent Protein Kinases EC 2.7.11.11
NTH1 protein, S cerevisiae EC 3.2.1.28
Trehalase EC 3.2.1.28

Banques de données

figshare
['10.6084/m9.figshare.11474685']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

655-671

Informations de copyright

© 2020 Plank et al.

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Auteurs

Michael Plank (M)

Department of Molecular Biology, University of Geneva, CH-1211, Geneva, Switzerland; National Centre of Competence in Research - Chemical Biology, University of Geneva, CH-1211, Geneva, Switzerland. Electronic address: michael.plank@unige.ch.

Mariya Perepelkina (M)

Department of Molecular Biology, University of Geneva, CH-1211, Geneva, Switzerland.

Markus Müller (M)

National Centre of Competence in Research - Chemical Biology, University of Geneva, CH-1211, Geneva, Switzerland; Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland.

Stefania Vaga (S)

Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, CH-8093 Zürich, Switzerland.

Xiaoming Zou (X)

Department of Molecular Biology, University of Geneva, CH-1211, Geneva, Switzerland.

Clélia Bourgoint (C)

Department of Molecular Biology, University of Geneva, CH-1211, Geneva, Switzerland.

Marina Berti (M)

Department of Molecular Biology, University of Geneva, CH-1211, Geneva, Switzerland.

Jacques Saarbach (J)

National Centre of Competence in Research - Chemical Biology, University of Geneva, CH-1211, Geneva, Switzerland; Department of Organic Chemistry, University of Geneva, CH-1211, Geneva, Switzerland.

Steven Haesendonckx (S)

Department of Molecular Biology, University of Geneva, CH-1211, Geneva, Switzerland.

Nicolas Winssinger (N)

National Centre of Competence in Research - Chemical Biology, University of Geneva, CH-1211, Geneva, Switzerland; Department of Organic Chemistry, University of Geneva, CH-1211, Geneva, Switzerland.

Ruedi Aebersold (R)

Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, CH-8093 Zürich, Switzerland; Faculty of Science, University of Zurich, CH-8006, Zurich, Switzerland.

Robbie Loewith (R)

Department of Molecular Biology, University of Geneva, CH-1211, Geneva, Switzerland; National Centre of Competence in Research - Chemical Biology, University of Geneva, CH-1211, Geneva, Switzerland. Electronic address: Robbie.Loewith@unige.ch.

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Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure secondaire des protéines › Motifs d'acides aminés › Chemical Genetics of AGC-kinases Reveals...
questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › Chemical Genetics of AGC-kinases Reveals...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Séquence conservée › Séquence consensus › Chemical Genetics of AGC-kinases Reveals...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Cyclic Nucleotide-Regulated Protein Kinases › Cyclic AMP-Dependent Protein Kinases › Chemical Genetics of AGC-kinases Reveals...
questionsmedicales.fr › Métabolisme › Phosphorylation › Chemical Genetics of AGC-kinases Reveals...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéines kinases › Chemical Genetics of AGC-kinases Reveals...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Chemical Genetics of AGC-kinases Reveals...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéome › Chemical Genetics of AGC-kinases Reveals...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Saccharomyces › Saccharomyces cerevisiae › Chemical Genetics of AGC-kinases Reveals...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Protéines de Saccharomyces cerevisiae › Chemical Genetics of AGC-kinases Reveals...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Disaccharidases › alpha, alpha-Trehalase › Chemical Genetics of AGC-kinases Reveals...