Genetic Profile and Functional Proteomics of Anal Squamous Cell Carcinoma: Proposal for a Molecular Classification.

Adult Aged Aged, 80 and over Anus Neoplasms / classification Carcinoma, Squamous Cell / classification Cell Adhesion / genetics Cell Proliferation / genetics Cohort Studies Female Gene Regulatory Networks Humans Lymphocytes, Tumor-Infiltrating / immunology Male Middle Aged Mutation / genetics Neoplasm Proteins / genetics Proteome / genetics Proteomics Exome Sequencing

Omics anal squamous cell carcinoma bioinformatics cancer biology mass spectrometry molecular biology molecular classification personalized medicine proteomics whole-exome sequencing

Journal

Molecular & cellular proteomics : MCP

ISSN: 1535-9484

Titre abrégé: Mol Cell Proteomics

Pays: United States

ID NLM: 101125647

Informations de publication

Date de publication:
04 2020

Historique:

received: 28 01 2020

pubmed: 29 2 2020

medline: 23 1 2021

entrez: 29 2 2020

Statut: ppublish

Résumé

Anal squamous cell carcinoma is a rare tumor. Chemo-radiotherapy yields a 50% 3-year relapse-free survival rate in advanced anal cancer, so improved predictive markers and therapeutic options are needed. High-throughput proteomics and whole-exome sequencing were performed in 46 paraffin samples from anal squamous cell carcinoma patients. Hierarchical clustering was used to establish groups

Identifiants

DOI: 10.1074/mcp.RA120.001954 PMID: 32107283 PMC: PMC7124473

pubmed: 32107283

pii: S1535-9476(20)35025-8

doi: 10.1074/mcp.RA120.001954

pmc: PMC7124473

pii:

doi:

Substances chimiques

Neoplasm Proteins 0

Proteome 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

690-700

Subventions

Organisme : NIMHD NIH HHS

ID : R01 MD007783

Pays : United States

Informations de copyright

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