Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8

Animals CD8-Positive T-Lymphocytes / drug effects Cell Differentiation / drug effects Cell Line, Tumor / transplantation Enzyme Inhibitors / pharmacology Humans Immunologic Memory Immunotherapy, Adoptive / methods Interleukin-2 / immunology Interleukins / immunology L-Lactate Dehydrogenase / antagonists & inhibitors Melanoma, Experimental / immunology Mice Primary Cell Culture Stem Cells / drug effects
IL-2 IL-21 LDH adoptive immunotherapy immunometabolism

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
17 03 2020
Historique:
pubmed: 4 3 2020
medline: 14 7 2020
entrez: 4 3 2020
Statut: ppublish

Résumé

Interleukin (IL)-2 and IL-21 dichotomously shape CD8

Identifiants

DOI: 10.1073/pnas.1920413117 PMID: 32123114 PMC: PMC7084161
pubmed: 32123114
pii: 1920413117
doi: 10.1073/pnas.1920413117
pmc: PMC7084161
doi:

Substances chimiques

Enzyme Inhibitors 0
Interleukin-2 0
Interleukins 0
L-Lactate Dehydrogenase EC 1.1.1.27
interleukin-21 MKM3CA6LT1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6047-6055

Subventions

Organisme : NIDDK NIH HHS
ID : DP1 DK113643
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA163591
Pays : United States

Déclaration de conflit d'intérêts

Competing interest statement: W.J.L. is an inventor on patents or patent applications related to IL-2 and IL-21. D.H., S.G., L.M.N., L.G., and W.J.L. are inventors on patent application(s) related to the LDH inhibitor described herein. L.G. is an inventor on a patent related to methods for generating TSCM cells.

Références

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Auteurs

Dalton Hermans (D)

Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.

Sanjivan Gautam (S)

Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892.

Juan C García-Cañaveras (JC)

Department of Chemistry, Princeton University, Princeton, NJ 08540.
Lewis-Sigler Institute, Princeton University, Princeton, NJ 08540.
ORCID: 0000-0001-7112-1537

Daniel Gromer (D)

Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.

Suman Mitra (S)

Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.

Rosanne Spolski (R)

Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.

Peng Li (P)

Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.

Stephen Christensen (S)

Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.

Rosa Nguyen (R)

Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.

Jian-Xin Lin (JX)

Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.

Jangsuk Oh (J)

Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.

Ning Du (N)

Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.

Sharon Veenbergen (S)

Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.

Jessica Fioravanti (J)

Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892.

Risa Ebina-Shibuya (R)

Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.

Christopher Bleck (C)

Electron Microscopy Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
ORCID: 0000-0003-1029-3444

Leonard M Neckers (LM)

Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892.
ORCID: 0000-0001-9639-7249

Joshua D Rabinowitz (JD)

Department of Chemistry, Princeton University, Princeton, NJ 08540.
Lewis-Sigler Institute, Princeton University, Princeton, NJ 08540.

Luca Gattinoni (L)

Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892; luca.gattinoni@ukr.de wjl@helix.nih.gov.
Regensburg Center for Interventional Immunology, University of Regensburg and University Hospital Regensburg, 93053 Regensburg, Germany.

Warren J Leonard (WJ)

Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892; luca.gattinoni@ukr.de wjl@helix.nih.gov.
ORCID: 0000-0002-5740-7448

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Lactate dehydrogenase inhibition synergizes...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Lactate dehydrogenase inhibition synergizes...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Lactate dehydrogenase inhibition synergizes...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Lactate dehydrogenase inhibition synergizes...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Lactate dehydrogenase inhibition synergizes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Lactate dehydrogenase inhibition synergizes...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Mémoire immunologique › Lactate dehydrogenase inhibition synergizes...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunisation passive › Transfert adoptif › Immunothérapie adoptive › Lactate dehydrogenase inhibition synergizes...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Lymphokines › Interleukine-2 › Lactate dehydrogenase inhibition synergizes...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Lactate dehydrogenase inhibition synergizes...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Alcohol oxidoreductases › NAD (+) and NADP (+) dependent Alcohol oxidoreductases › L-Lactate dehydrogenase › Lactate dehydrogenase inhibition synergizes...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Tumeurs expérimentales › Mélanome expérimental › Lactate dehydrogenase inhibition synergizes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lactate dehydrogenase inhibition synergizes...
questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › Techniques de culture › Techniques de culture cellulaire › Culture de cellules primaires › Lactate dehydrogenase inhibition synergizes...
questionsmedicales.fr › Cellules › Cellules souches › Lactate dehydrogenase inhibition synergizes...