Diagnostic value of plasma phosphorylated tau181 in Alzheimer's disease and frontotemporal lobar degeneration.


Journal

Nature medicine
ISSN: 1546-170X
Titre abrégé: Nat Med
Pays: United States
ID NLM: 9502015

Informations de publication

Date de publication:
03 2020
Historique:
received: 19 07 2019
accepted: 10 01 2020
pubmed: 4 3 2020
medline: 9 4 2020
entrez: 4 3 2020
Statut: ppublish

Résumé

With the potential development of new disease-modifying Alzheimer's disease (AD) therapies, simple, widely available screening tests are needed to identify which individuals, who are experiencing symptoms of cognitive or behavioral decline, should be further evaluated for initiation of treatment. A blood-based test for AD would be a less invasive and less expensive screening tool than the currently approved cerebrospinal fluid or amyloid β positron emission tomography (PET) diagnostic tests. We examined whether plasma tau phosphorylated at residue 181 (pTau181) could differentiate between clinically diagnosed or autopsy-confirmed AD and frontotemporal lobar degeneration. Plasma pTau181 concentrations were increased by 3.5-fold in AD compared to controls and differentiated AD from both clinically diagnosed (receiver operating characteristic area under the curve of 0.894) and autopsy-confirmed frontotemporal lobar degeneration (area under the curve of 0.878). Plasma pTau181 identified individuals who were amyloid β-PET-positive regardless of clinical diagnosis and correlated with cortical tau protein deposition measured by

Identifiants

pubmed: 32123386
doi: 10.1038/s41591-020-0762-2
pii: 10.1038/s41591-020-0762-2
pmc: PMC7101073
mid: NIHMS1549223
doi:

Substances chimiques

Amyloid 0
Amyloid beta-Peptides 0
Biomarkers 0
Neurofilament Proteins 0
neurofilament protein L 0
tau Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

387-397

Subventions

Organisme : NIA NIH HHS
ID : P50 AG023501
Pays : United States
Organisme : NIA NIH HHS
ID : K24 AG045333
Pays : United States
Organisme : NIA NIH HHS
ID : U24 AG021886
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG016574
Pays : United States
Organisme : NIA NIH HHS
ID : K24 AG053435
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG038791
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG063911
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG050967
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG019724
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG066597
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH120794
Pays : United States
Organisme : NIA NIH HHS
ID : K23 AG059888
Pays : United States
Organisme : NIA NIH HHS
ID : K08 AG052648
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG062268
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG045390
Pays : United States
Organisme : NINDS NIH HHS
ID : U54 NS092089
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG045611
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG023481
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG062422
Pays : United States

Investigateurs

Leah Forsberg (L)
David S Knopman (DS)
Neill Graff-Radford (N)
Murray Grossman (M)
Edward H Huey (EH)
Chiadi Onyike (C)
Daniel Kaufer (D)
Erik Roberson (E)
Nupur Ghoshal (N)
Sandra Weintraub (S)
Brian Appleby (B)
Irene Litvan (I)
Diana Kerwin (D)
Mario Mendez (M)
Yvette Bordelon (Y)
Giovanni Coppola (G)
Eliana Marisa Ramos (EM)
M Carmela Tartaglia (MC)
Ging-Yuek Hsiung (GY)
Ian MacKenzie (I)
Kimiko Domoto-Reilly (K)
Tatiana Foroud (T)
Bradford C Dickerson (BC)

Commentaires et corrections

Type : CommentIn
Type : CommentIn

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Auteurs

Elisabeth H Thijssen (EH)

Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands.

Renaud La Joie (R)

Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.

Amy Wolf (A)

Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.

Amelia Strom (A)

Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.

Ping Wang (P)

Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.

Leonardo Iaccarino (L)

Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.

Viktoriya Bourakova (V)

Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.

Yann Cobigo (Y)

Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.

Hilary Heuer (H)

Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.

Salvatore Spina (S)

Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.

Lawren VandeVrede (L)

Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.

Xiyun Chai (X)

Eli Lilly and Company, Indianapolis, IN, USA.

Nicholas K Proctor (NK)

Eli Lilly and Company, Indianapolis, IN, USA.

David C Airey (DC)

Eli Lilly and Company, Indianapolis, IN, USA.

Sergey Shcherbinin (S)

Eli Lilly and Company, Indianapolis, IN, USA.

Cynthia Duggan Evans (C)

Eli Lilly and Company, Indianapolis, IN, USA.

John R Sims (JR)

Eli Lilly and Company, Indianapolis, IN, USA.

Henrik Zetterberg (H)

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, UK.
UK Dementia Research Institute, University College London, London, UK.

Kaj Blennow (K)

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.

Anna M Karydas (AM)

Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.

Charlotte E Teunissen (CE)

Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands.

Joel H Kramer (JH)

Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.

Lea T Grinberg (LT)

Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Department of Pathology, University of California San Francisco, San Francisco, CA, USA.

William W Seeley (WW)

Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Department of Pathology, University of California San Francisco, San Francisco, CA, USA.

Howie Rosen (H)

Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.

Bradley F Boeve (BF)

Department of Neurology, Mayo Clinic, Rochester, MN, USA.

Bruce L Miller (BL)

Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.

Gil D Rabinovici (GD)

Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.

Jeffrey L Dage (JL)

Eli Lilly and Company, Indianapolis, IN, USA.

Julio C Rojas (JC)

Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.

Adam L Boxer (AL)

Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA. adam.boxer@ucsf.edu.

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Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
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Humans Yoga Low Back Pain Female Male

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