The participation of basolateral amygdala in the efficacy of acupuncture with deqi treating for functional dyspepsia.
Amygdala subregions
Deqi
Functional connectivity
Functional dyspepsia
fMRI
Journal
Brain imaging and behavior
ISSN: 1931-7565
Titre abrégé: Brain Imaging Behav
Pays: United States
ID NLM: 101300405
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
pubmed:
4
3
2020
medline:
28
4
2021
entrez:
4
3
2020
Statut:
ppublish
Résumé
Deqi is taken as an indispensable requirement to achieve acupuncture efficacy. This study aimed to explore the central influence of deqi on the efficacy of acupuncture for functional dyspepsia (FD). 70 FD patients were randomized to receive 20 sessions' acupuncture treatment with (n = 35) and without deqi (n = 35). In each group, 25 FD patients randomly selected underwent functional magnetic resonance imaging (fMRI) scans before and after treatment. After group re-division according to deqi response, changes of amygdala subregions-based resting-state functional connectivity (rsFC) were compared between the acupuncture with and without obvious deqi group. The clinical changes of the Nepean Dyspepsia Symptom Index (NDSI) measuring FD symptoms were also used to further assess the correlation with amygdala subregions rsFC in FD patients. The decrease in the NDSI scores (pre-pos) in the obvious deqi group was significantly greater than that in the acupuncture without obvious deqi group (p < 0.05). Compared to the without obvious deqi group, the obvious deqi group showed significantly decreased the left basolateral amygdala (BLA) rsFC with bilateral insular (INS), putamen and middle/posterior cingulate cortex (MCC/PCC), right pallidum and hippocampus (HIPP) after treatment. The changed NDSI scores(pre-post) of all 41 FD patients was significantly positively correlated with their Fisher's transformed z value of the left BLA rsFC with left INS (r = 0.376, FDR corrected p = 0.015), and rsFC with right HIPP (r = 0.394, FDR corrected p = 0.015). The changed NDSI scores(pre-post) of the obvious deqi group was significantly negatively correlated with their Fisher's transformed z value of the right centromedial amygdala (CMA) rsFC with left medial prefrontal cortex (mPFC) (r = -0.463, p = 0.035). The results tested the hypothesis that the advantage of deqi on efficacy is related to affecting the BLA and CMA rsFC. It suggested that deqi might influence the abnormal rsFC within the salience network (SN), and participate in the adaptive modulation of disrupted relationship between the SN and default mode network (DMN).
Identifiants
pubmed: 32125619
doi: 10.1007/s11682-019-00249-7
pii: 10.1007/s11682-019-00249-7
doi:
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
216-230Subventions
Organisme : National Outstanding Youth Science Fund Project of National Natural Science Foundation of China
ID : NO.81622052
Organisme : National Natural Science Foundation of China
ID : NO.81473602
Organisme : the major program of the National Natural Science Foundation of China
ID : NO.81590950
Organisme : the Ten Thousand Talent Program
ID : W02020595
Organisme : Guangdong Province Introduction of Innovative R&D Team (CN)
ID : 2019JDTD0011
Références
Abdi, H., Tayefi, M., Moallem, S. R., Zhao, B., Fayaz, M., Ardabili, H. M., Razavi, A. A., Darbandi, M., Darbandi, S., Abbasi, P., Ferns, G. A., & Ghayour-Mobarhan, M. (2017). Abdominal and auricular acupuncture reduces blood pressure in hypertensive patients. Complementary Therapies in Medicine, 31, 20–26. https://doi.org/10.1016/j.ctim.2017.01.003 .
doi: 10.1016/j.ctim.2017.01.003
pubmed: 28434467
Adam, B., Liebregts, T., Saadat-Gilani, K., Vinson, B., & Holtmann, G. (2005). Validation of the gastrointestinal symptom score for the assessment of symptoms in patients with functional dyspepsia. Alimentary Pharmacology & Therapeutics, 22(4), 357–363. https://doi.org/10.1111/j.1365-2036.2005.02572.x .
doi: 10.1111/j.1365-2036.2005.02572.x
Andresen, V., Bach, D. R., Poellinger, A., Tsrouya, C., Stroh, A., Foerschler, A., Georgiewa, P., Zimmer, C., & Mönnikes, H. (2005). Brain activation responses to subliminal or supraliminal rectal stimuli and to auditory stimuli in irritable bowel syndrome. Neurogastroenterology and Motility, 17(6), 827–837. https://doi.org/10.1111/j.1365-2982.2005.00720.x .
doi: 10.1111/j.1365-2982.2005.00720.x
pubmed: 16336498
Aro, P., Talley, N. J., Johansson, S. E., Agreus, L., & Ronkainen, J. (2015). Anxiety is linked to new-onset dyspepsia in the Swedish population: A 10-year follow-up study. Gastroenterology, 148(5), 928–937. https://doi.org/10.1053/j.gastro.2015.01.039 .
doi: 10.1053/j.gastro.2015.01.039
pubmed: 25644097
Asghar, A. U., Green, G., Lythgoe, M. F., Lewith, G., & MacPherson, H. (2010). Acupuncture needling sensation: The neural correlates of deqi using fMRI. Brain Research, 1315, 111–118. https://doi.org/10.1016/j.brainres.2009.12.019 .
doi: 10.1016/j.brainres.2009.12.019
pubmed: 20025853
Aziz, Q., Schnitzler, A., & Enck, P. (2000). Functional neuroimaging of visceral sensation. Journal of Clinical Neurophysiology, 17(6), 604–612.
doi: 10.1097/00004691-200011000-00006
Balderston, N. L., Schultz, D. H., Hopkins, L., & Helmstetter, F. J. (2015). Functionally distinct amygdala subregions identified using DTI and high-resolution fMRI. Social Cognitive and Affective Neuroscience, 10(12), 1615–1622. https://doi.org/10.1093/scan/nsv055 .
doi: 10.1093/scan/nsv055
pubmed: 25969533
pmcid: 4666105
Brewer, J. A., Worhunsky, P. D., Gray, J. R., Tang, Y. Y., Weber, J., & Kober, H. (2011). Meditation experience is associated with differences in default mode network activity and connectivity. Proceedings of the National Academy of Sciences of the United States of America, 108(50), 20254–20259. https://doi.org/10.1073/pnas.1112029108 .
doi: 10.1073/pnas.1112029108
pubmed: 22114193
pmcid: 3250176
Desmond, J. E., & Glover, G. H. (2002). Estimating sample size in functional MRI (fMRI) neuroimaging studies: Statistical power analyses. Journal of Neuroscience Methods, 118(2), 115–128. https://doi.org/10.1016/s0165-0270(02)00121-8 .
doi: 10.1016/s0165-0270(02)00121-8
pubmed: 12204303
Fang, J., Jin, Z., Wang, Y., Li, K., Kong, J., Nixon, E. E., Zeng, Y., Ren, Y., Tong, H., Wang, Y., Wang, P., & Hui, K. K. (2009). The salient characteristics of the central effects of acupuncture needling: Limbic-paralimbic-neocortical network modulation. Human Brain Mapping, 30(4), 1196–1206. https://doi.org/10.1002/hbm.20583 .
doi: 10.1002/hbm.20583
pubmed: 18571795
Fox, M. D., Snyder, A. Z., Vincent, J. L., Corbetta, M., Van Essen, D. C., & Raichle, M. E. (2005). The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proceedings of the National Academy of Sciences of the United States of America, 102(27), 9673–9678. https://doi.org/10.1073/pnas.0504136102 .
doi: 10.1073/pnas.0504136102
pubmed: 15976020
pmcid: 1157105
Ghoshal, U. C., Singh, R., Chang, F. Y., Hou, X., Wong, B. C., & Kachintorn, U. (2011). Epidemiology of uninvestigated and functional dyspepsia in Asia: Facts and fiction. Journal of Neurogastroenterology and Motility, 17(3), 235–244. https://doi.org/10.5056/jnm.2011.17.3.235 .
doi: 10.5056/jnm.2011.17.3.235
pubmed: 21860815
pmcid: 3155059
Gusnard, D. A., Akbudak, E., Shulman, G. L., & Raichle, M. E. (2001). Medial prefrontal cortex and self-referential mental activity: Relation to a default mode of brain function. Proceedings of the National Academy of Sciences of the United States of America, 98(7), 4259–4264. https://doi.org/10.1073/pnas.071043098 .
doi: 10.1073/pnas.071043098
pubmed: 11259662
pmcid: 31213
He, Y., Xu, T., Zhang, W., & Zuo, X. N. (2016). Lifespan anxiety is reflected in human amygdala cortical connectivity. Human Brain Mapping, 37(3), 1178–1193. https://doi.org/10.1002/hbm.23094 .
doi: 10.1002/hbm.23094
pubmed: 26859312
Ho, L. F., Lin, Z. X., Leung, A. W. N., Chen, L., Zhang, H., Ng, B. F. L., Ziea, E. T. C., & Guo, Y. (2017). Efficacy of abdominal acupuncture for neck pain: A randomized controlled trial. PLoS One, 12(7), e0181360. https://doi.org/10.1371/journal.pone.0181360 .
doi: 10.1371/journal.pone.0181360
pubmed: 28715459
pmcid: 5513533
Hui, K. K., Liu, J., Marina, O., Napadow, V., Haselgrove, C., Kwong, K. K., et al. (2005). The integrated response of the human cerebro-cerebellar and limbic systems to acupuncture stimulation at ST 36 as evidenced by fMRI. Neuroimage, 27(3), 479–496. https://doi.org/10.1016/j.neuroimage.2005.04.037 .
doi: 10.1016/j.neuroimage.2005.04.037
pubmed: 16046146
Hui, K. K., Marina, O., Liu, J., Rosen, B. R., & Kwong, K. K. (2010). Acupuncture, the limbic system, and the anticorrelated networks of the brain. Autonomic Neuroscience, 157(1–2), 81–90. https://doi.org/10.1016/j.autneu.2010.03.022 .
doi: 10.1016/j.autneu.2010.03.022
pubmed: 20494627
Jin, L. M., Qin, C. J., Lan, L., Sun, J. B., Zeng, F., Zhu, Y. Q., Yu, S. G., Yin, H. Y., & Tang, Y. (2014). Local anesthesia at ST36 to reveal responding brain areas to deqi. Evidence-based Complementary and Alternative Medicine, 2014, 987365. https://doi.org/10.1155/2014/987365 .
doi: 10.1155/2014/987365
pubmed: 24550995
pmcid: 3914330
Kano, M., Dupont, P., Aziz, Q., & Fukudo, S. (2018). Understanding Neurogastroenterology from neuroimaging perspective: A comprehensive review of functional and structural brain imaging in functional gastrointestinal disorders. Journal of Neurogastroenterology and Motility, 24(4), 512–527. https://doi.org/10.5056/jnm18072 .
doi: 10.5056/jnm18072
pubmed: 30041284
pmcid: 6175554
Ko, S. J., Kuo, B., Kim, S. K., Lee, H., Kim, J., Han, G., Kim, J., Kim, S. Y., Jang, S., Son, J., Kim, M., Lee, H., Yeo, I., Joo, K. R., & Park, J. W. (2016). Individualized acupuncture for symptom relief in functional dyspepsia: A randomized controlled trial. Journal of Alternative and Complementary Medicine, 22(12), 997–1006. https://doi.org/10.1089/acm.2016.0208 .
doi: 10.1089/acm.2016.0208
pubmed: 27732083
Kong, J., Gollub, R., Huang, T., Polich, G., Napadow, V., Hui, K., Vangel, M., Rosen, B., & Kaptchuk, T. J. (2007). Acupuncture de qi, from qualitative history to quantitative measurement. Journal of Alternative and Complementary Medicine, 13(10), 1059–1070. https://doi.org/10.1089/acm.2007.0524 .
doi: 10.1089/acm.2007.0524
pubmed: 18166116
Ladabaum, U., Minoshima, S., Hasler, W. L., Cross, D., Chey, W. D., & Owyang, C. (2001). Gastric distention correlates with activation of multiple cortical and subcortical regions. Gastroenterology, 120(2), 369–376. https://doi.org/10.1053/gast.2001.21201 .
doi: 10.1053/gast.2001.21201
pubmed: 11159877
Lalitha, V., Pal, G. K., Pal, P., Parija, S. C., & Murugaiyan, S. B. (2016). Gender difference in the role of Posterodorsal amygdala on the regulation of food intake, adiposity and immunological responses in albino Wistar rats. Annals of Neurosciences, 23(1), 6–12. https://doi.org/10.1159/000443550 .
doi: 10.1159/000443550
pubmed: 27536016
pmcid: 4934414
Lee, I. S., Wang, H., Chae, Y., Preissl, H., & Enck, P. (2016). Functional neuroimaging studies in functional dyspepsia patients: A systematic review. Neurogastroenterology and Motility, 28(6), 793–805. https://doi.org/10.1111/nmo.12793 .
doi: 10.1111/nmo.12793
pubmed: 26940430
Li, H., Liu, H., Liu, C., Shi, G., Zhou, W., Zhao, C., et al. (2014). Effect of "Deqi" during the study of needling "Wang's Jiaji" Acupoints treating spasticity after stroke. Evidence-based Complementary and Alternative Medicine, 2014, 715351. https://doi.org/10.1155/2014/715351 .
doi: 10.1155/2014/715351
pubmed: 25477996
pmcid: 4247953
Li, M. K., Li, Y. J., Zhang, G. F., Chen, J. Q., Zhang, J. P., Qi, J., Huang, Y., Lai, X. S., & Tang, C. Z. (2015). Acupuncture for ischemic stroke: Cerebellar activation may be a central mechanism following Deqi. Neural Regeneration Research, 10(12), 1997–2003. https://doi.org/10.4103/1673-5374.172318 .
doi: 10.4103/1673-5374.172318
pubmed: 26889189
pmcid: 4730825
Li, M., Yuan, H., Wang, P., Xin, S., Hao, J., Liu, M., Li, J., Yu, M., & Zhang, X. (2017). Influences of De Qi induced by acupuncture on immediate and accumulated analgesic effects in patients with knee osteoarthritis: Study protocol for a randomized controlled trial. Trials, 18(1), 251. https://doi.org/10.1186/s13063-017-1975-7 .
doi: 10.1186/s13063-017-1975-7
pubmed: 28583145
pmcid: 5460357
Liu, S., Zhou, W., Ruan, X., Li, R., Lee, T., Weng, X., Hu, J., & Yang, G. (2007). Activation of the hypothalamus characterizes the response to acupuncture stimulation in heroin addicts. Neuroscience Letters, 421(3), 203–208. https://doi.org/10.1016/j.neulet.2007.04.078 .
doi: 10.1016/j.neulet.2007.04.078
pubmed: 17574746
Liu, J., Mu, J., Liu, Q., Dun, W., Zhang, M., & Tian, J. (2017). Brain structural properties predict psychologically mediated hypoalgesia in an 8-week sham acupuncture treatment for migraine. Human Brain Mapping, 38(9), 4386–4397. https://doi.org/10.1002/hbm.23667 .
doi: 10.1002/hbm.23667
pubmed: 28608601
pmcid: 6866832
Liu, J., Mu, J., Chen, T., Zhang, M., & Tian, J. (2019). White matter tract microstructure of the mPFC-amygdala predicts interindividual differences in placebo response related to treatment in migraine patients. Human Brain Mapping, 40(1), 284–292. https://doi.org/10.1002/hbm.24372 .
doi: 10.1002/hbm.24372
pubmed: 30256491
Ma, T., Zeng, F., Li, Y., Wang, C. M., Tian, X., Yu, S., Zhao, L., Wu, X., Yang, M., Wang, D., & Liang, F. (2015). Which subtype of functional dyspepsia patients responses better to acupuncture? A retrospective analysis of a randomized controlled trial. Forschende Komplementärmedizin, 22(2), 94–100. https://doi.org/10.1159/000380983 .
doi: 10.1159/000380983
pubmed: 26021959
Mahadeva, S., & Ford, A. C. (2016). Clinical and epidemiological differences in functional dyspepsia between the east and the west. Neurogastroenterology and Motility, 28(2), 167–174. https://doi.org/10.1111/nmo.12657 .
doi: 10.1111/nmo.12657
pubmed: 26331919
Mayer, E. A., Naliboff, B., Lee, O., Munakata, J., & Chang, L. (1999). Review article: Gender-related differences in functional gastrointestinal disorders. Alimentary Pharmacology & Therapeutics, 13(Suppl 2), 65–69.
doi: 10.1046/j.1365-2036.1999.00008.x
Menon, V. K. (2019). Mechanically relevant anatomy of the Axis vertebra and its relation to Hangman's fracture: An illustrated essay. Neurospine, 16(2), 223–230. https://doi.org/10.14245/ns.1938140.070 .
doi: 10.14245/ns.1938140.070
pubmed: 31261461
pmcid: 6603824
Nan, J., Liu, J., Li, G., Xiong, S., Yan, X., Yin, Q., Zeng, F., von Deneen, K., Liang, F., Gong, Q., Qin, W., & Tian, J. (2013). Whole-brain functional connectivity identification of functional dyspepsia. PLoS One, 8(6), e65870. https://doi.org/10.1371/journal.pone.0065870 .
doi: 10.1371/journal.pone.0065870
pubmed: 23799056
pmcid: 3684590
Nan, J., Liu, J., Mu, J., Dun, W., Zhang, M., Gong, Q., Qin, W., Tian, J., Liang, F., & Zeng, F. (2015). Brain-based correlations between psychological factors and functional dyspepsia. Journal of Neurogastroenterology and Motility, 21(1), 103–110. https://doi.org/10.5056/jnm14096 .
doi: 10.5056/jnm14096
pubmed: 25540947
pmcid: 4288085
Napadow, V., Kettner, N., Liu, J., Li, M., Kwong, K. K., Vangel, M., Makris, N., Audette, J., & Hui, K. K. (2007). Hypothalamus and amygdala response to acupuncture stimuli in carpal tunnel syndrome. Pain, 130(3), 254–266. https://doi.org/10.1016/j.pain.2006.12.003 .
doi: 10.1016/j.pain.2006.12.003
pubmed: 17240066
pmcid: 1997288
Northoff, G., Heinzel, A., de Greck, M., Bermpohl, F., Dobrowolny, H., & Panksepp, J. (2006). Self-referential processing in our brain--a meta-analysis of imaging studies on the self. Neuroimage, 31(1), 440–457. https://doi.org/10.1016/j.neuroimage.2005.12.002 .
doi: 10.1016/j.neuroimage.2005.12.002
pubmed: 16466680
Pang, B., Jiang, T., Du, Y. H., Li, J., Li, B., Hu, Y. C., et al. (2016). Acupuncture for functional dyspepsia: What strength does it have? A systematic review and meta-analysis of randomized controlled trials. Evidence-based Complementary and Alternative Medicine, 2016, 3862916. https://doi.org/10.1155/2016/3862916 .
doi: 10.1155/2016/3862916
pubmed: 28119758
pmcid: 5227170
Pariente, J., White, P., Frackowiak, R. S., & Lewith, G. (2005). Expectancy and belief modulate the neuronal substrates of pain treated by acupuncture. Neuroimage, 25(4), 1161–1167. https://doi.org/10.1016/j.neuroimage.2005.01.016 .
doi: 10.1016/j.neuroimage.2005.01.016
pubmed: 15850733
Qin, W., Tian, J., Bai, L., Pan, X., Yang, L., Chen, P., Dai, J., Ai, L., Zhao, B., Gong, Q., Wang, W., von Deneen, K., & Liu, Y. (2008). FMRI connectivity analysis of acupuncture effects on an amygdala-associated brain network. Molecular Pain, 4, 55. https://doi.org/10.1186/1744-8069-4-55 .
doi: 10.1186/1744-8069-4-55
pubmed: 19014532
pmcid: 2596101
Qiu, K., Jing, M., Sun, R., Yang, J., Liu, X., He, Z., Yin, S., Lan, Y., Cheng, S., Gao, F., Liang, F., & Zeng, F. (2016). The status of the quality control in acupuncture-neuroimaging studies. Evidence-based Complementary and Alternative Medicine, 2016, 3685785. https://doi.org/10.1155/2016/3685785 .
doi: 10.1155/2016/3685785
pubmed: 27242911
pmcid: 4875991
Shi, G. X., Yang, X. M., Liu, C. Z., & Wang, L. P. (2012). Factors contributing to therapeutic effects evaluated in acupuncture clinical trials. Trials, 13, 42. https://doi.org/10.1186/1745-6215-13-42 .
doi: 10.1186/1745-6215-13-42
pubmed: 22520963
pmcid: 3404896
Shi, G. X., Li, Q. Q., Liu, C. Z., Zhu, J., Wang, L. P., Wang, J., Han, L. L., Guan, L. P., & Wu, M. M. (2014). Effect of acupuncture on Deqi traits and pain intensity in primary dysmenorrhea: Analysis of data from a larger randomized controlled trial. BMC Complementary and Alternative Medicine, 14, 69. https://doi.org/10.1186/1472-6882-14-69 .
doi: 10.1186/1472-6882-14-69
pubmed: 24555788
pmcid: 3933504
Spaeth, R. B., Camhi, S., Hashmi, J. A., Vangel, M., Wasan, A. D., Edwards, R. R., Gollub, R. L., & Kong, J. (2013). A longitudinal study of the reliability of acupuncture deqi sensations in knee osteoarthritis. Evidence-based Complementary and Alternative Medicine, 2013, 204259. https://doi.org/10.1155/2013/204259 .
doi: 10.1155/2013/204259
pubmed: 23935656
pmcid: 3713327
Sun, R., Hong, X., Guo, J., Yin, S., Feng, P., Lan, L., Lei, D., Liu, X., Suo, X., Yin, T., Zhang, T., Huang, L., Gao, F., Gong, Q., Liang, F., & Zeng, F. (2018). The central mechanism of acupuncture treatment with a long-lasting effect for functional dyspepsia: Study protocol for a randomized controlled trial. Trials, 19(1), 373. https://doi.org/10.1186/s13063-018-2742-0 .
doi: 10.1186/s13063-018-2742-0
pubmed: 30001732
pmcid: 6043952
Swanson, L. W. (2003). The amygdala and its place in the cerebral hemisphere. Annals of the New York Academy of Sciences, 985, 174–184. https://doi.org/10.1111/j.1749-6632.2003.tb07081.x .
doi: 10.1111/j.1749-6632.2003.tb07081.x
pubmed: 12724158
Tack, J., & Talley, N. J. (2013). Functional dyspepsia--symptoms, definitions and validity of the Rome III criteria. Nature Reviews. Gastroenterology & Hepatology, 10(3), 134–141. https://doi.org/10.1038/nrgastro.2013.14 .
doi: 10.1038/nrgastro.2013.14
Takahashi, T. (2006). Acupuncture for functional gastrointestinal disorders. Journal of Gastroenterology, 41(5), 408–417. https://doi.org/10.1007/s00535-006-1773-6 .
doi: 10.1007/s00535-006-1773-6
pubmed: 16799881
Talley, N. J. (2017). Functional dyspepsia: Advances in diagnosis and therapy. Gut and Liver, 11(3), 349–357. https://doi.org/10.5009/gnl16055 .
doi: 10.5009/gnl16055
pubmed: 28452210
pmcid: 5417776
Talley, N. J., Locke 3rd, G. R., Lahr, B. D., Zinsmeister, A. R., Tougas, G., Ligozio, G., et al. (2006). Functional dyspepsia, delayed gastric emptying, and impaired quality of life. Gut, 55(7), 933–939. https://doi.org/10.1136/gut.2005.078634 .
doi: 10.1136/gut.2005.078634
pubmed: 16322108
pmcid: 1856317
Tian, X. P., Li, Y., Liang, F. R., Sun, G. J., Yan, J., Chang, X. R., Ma, T. T., Yu, S. Y., & Yang, X. G. (2009). Translation and validation of the Nepean dyspepsia index for functional dyspepsia in China. World Journal of Gastroenterology, 15(25), 3173–3177. https://doi.org/10.3748/wjg.15.3173 .
doi: 10.3748/wjg.15.3173
pubmed: 19575499
pmcid: 2705742
Van Oudenhove, L., Coen, S. J., & Aziz, Q. (2007). Functional brain imaging of gastrointestinal sensation in health and disease. World Journal of Gastroenterology, 13(25), 3438–3445. https://doi.org/10.3748/wjg.v13.i25.3438 .
doi: 10.3748/wjg.v13.i25.3438
pubmed: 17659690
pmcid: 4146779
Van Oudenhove, L., Vandenberghe, J., Dupont, P., Geeraerts, B., Vos, R., Dirix, S., et al. (2010a). Abnormal regional brain activity during rest and (anticipated) gastric distension in functional dyspepsia and the role of anxiety: A H(2)(15)O-PET study. The American Journal of Gastroenterology, 105(4), 913–924. https://doi.org/10.1038/ajg.2010.39 .
doi: 10.1038/ajg.2010.39
pubmed: 20160711
Van Oudenhove, L., Vandenberghe, J., Dupont, P., Geeraerts, B., Vos, R., Dirix, S., et al. (2010b). Regional brain activity in functional dyspepsia: A H(2)(15)O-PET study on the role of gastric sensitivity and abuse history. Gastroenterology, 139(1), 36–47. https://doi.org/10.1053/j.gastro.2010.04.015 .
doi: 10.1053/j.gastro.2010.04.015
pubmed: 20406641
Vandenbergh, J., Dupont, P., Fischler, B., Bormans, G., Persoons, P., Janssens, J., & Tack, J. (2005). Regional brain activation during proximal stomach distention in humans: A positron emission tomography study. Gastroenterology, 128(3), 564–573. https://doi.org/10.1053/j.gastro.2004.11.054 .
doi: 10.1053/j.gastro.2004.11.054
pubmed: 15765391
Vanner, S., Greenwood-Van Meerveld, B., Mawe, G., Shea-Donohue, T., Verdu, E. F., Wood, J., et al. (2016). Fundamentals of neurogastroenterology: Basic Science. Gastroenterology. https://doi.org/10.1053/j.gastro.2016.02.018 .
Wang, G. J., Tomasi, D., Backus, W., Wang, R., Telang, F., Geliebter, A., Korner, J., Bauman, A., Fowler, J. S., Thanos, P. K., & Volkow, N. D. (2008). Gastric distention activates satiety circuitry in the human brain. Neuroimage, 39(4), 1824–1831. https://doi.org/10.1016/j.neuroimage.2007.11.008 .
doi: 10.1016/j.neuroimage.2007.11.008
pubmed: 18155924
Wang, X., Wang, Z., Liu, J., Chen, J., Liu, X., Nie, G., Byun, J. S., Liang, Y., Park, J., Huang, R., Liu, M., Liu, B., & Kong, J. (2016). Repeated acupuncture treatments modulate amygdala resting state functional connectivity of depressive patients. NeuroImage: Clinical, 12, 746–752. https://doi.org/10.1016/j.nicl.2016.07.011 .
doi: 10.1016/j.nicl.2016.07.011
Whitfield-Gabrieli, S., & Nieto-Castanon, A. (2012). Conn: A functional connectivity toolbox for correlated and anticorrelated brain networks. Brain Connectivity, 2(3), 125–141. https://doi.org/10.1089/brain.2012.0073 .
doi: 10.1089/brain.2012.0073
pubmed: 22642651
Wilder-Smith, C. H., Schindler, D., Lovblad, K., Redmond, S. M., & Nirkko, A. (2004). Brain functional magnetic resonance imaging of rectal pain and activation of endogenous inhibitory mechanisms in irritable bowel syndrome patient subgroups and healthy controls. Gut, 53(11), 1595–1601. https://doi.org/10.1136/gut.2003.028514 .
doi: 10.1136/gut.2003.028514
pubmed: 15479679
pmcid: 1774298
Xu, S., Hou, X., Zha, H., Gao, Z., Zhang, Y., & Chen, J. D. (2006). Electroacupuncture accelerates solid gastric emptying and improves dyspeptic symptoms in patients with functional dyspepsia. Digestive Diseases and Sciences, 51(12), 2154–2159. https://doi.org/10.1007/s10620-006-9412-x .
doi: 10.1007/s10620-006-9412-x
pubmed: 17082991
Yang, X. Y., Shi, G. X., Li, Q. Q., Zhang, Z. H., Xu, Q., & Liu, C. Z. (2013). Characterization of deqi sensation and acupuncture effect. Evidence-based Complementary and Alternative Medicine, 2013, 319734. https://doi.org/10.1155/2013/319734 .
doi: 10.1155/2013/319734
pubmed: 23864884
pmcid: 3705793
Yin, X., Gou, M., Xu, J., Dong, B., Yin, P., Masquelin, F., Wu, J., Lao, L., & Xu, S. (2017). Efficacy and safety of acupuncture treatment on primary insomnia: A randomized controlled trial. Sleep Medicine, 37, 193–200. https://doi.org/10.1016/j.sleep.2017.02.012 .
doi: 10.1016/j.sleep.2017.02.012
pubmed: 28899535
Yu, D. T., Jones, A. Y., & Pang, M. Y. (2012). Development and validation of the Chinese version of the Massachusetts General Hospital acupuncture sensation scale: An exploratory and methodological study. Acupuncture in Medicine, 30(3), 214–221. https://doi.org/10.1136/acupmed-2012-010145 .
doi: 10.1136/acupmed-2012-010145
pubmed: 22617434
Zeng, F., Qin, W., Liang, F., Liu, J., Tang, Y., Liu, X., Yuan, K., Yu, S., Song, W., Liu, M., Lan, L., Gao, X., Liu, Y., & Tian, J. (2011). Abnormal resting brain activity in patients with functional dyspepsia is related to symptom severity. Gastroenterology, 141(2), 499–506. https://doi.org/10.1053/j.gastro.2011.05.003 .
doi: 10.1053/j.gastro.2011.05.003
pubmed: 21684280
Zeng, F., Qin, W., Ma, T., Sun, J., Tang, Y., Yuan, K., Li, Y., Liu, J., Liu, X., Song, W., Lan, L., Liu, M., Yu, S., Gao, X., Tian, J., & Liang, F. (2012). Influence of acupuncture treatment on cerebral activity in functional dyspepsia patients and its relationship with efficacy. The American Journal of Gastroenterology, 107(8), 1236–1247. https://doi.org/10.1038/ajg.2012.53 .
doi: 10.1038/ajg.2012.53
pubmed: 22641307
Zeng, F., Lan, L., Tang, Y., Liu, M., Liu, X., Song, W., Li, Y., Qin, W., Sun, J., Yu, S., Gao, X., Tian, J., & Liang, F. (2015). Cerebral responses to puncturing at different acupoints for treating meal-related functional dyspepsia. Neurogastroenterology and Motility, 27(4), 559–568. https://doi.org/10.1111/nmo.12532 .
doi: 10.1111/nmo.12532
pubmed: 25693969
Zeng, F., Sun, R., He, Z., Chen, Y., Lei, D., Yin, T., et al. (2019). Altered functional connectivity of the amygdala and sex differences in functional dyspepsia. Clinical and Translational Gastroenterology, 10(6), e00046. https://doi.org/10.14309/ctg.0000000000000046 .
doi: 10.14309/ctg.0000000000000046
pubmed: 31136362
pmcid: 6613861
Zhao, L., Chen, J., Li, Y., Sun, X., Chang, X., Zheng, H., Gong, B., Huang, Y., Yang, M., Wu, X., Li, X., & Liang, F. (2017). The long-term effect of acupuncture for migraine prophylaxis: A randomized clinical trial. JAMA Internal Medicine, 177(4), 508–515. https://doi.org/10.1001/jamainternmed.2016.9378 .
doi: 10.1001/jamainternmed.2016.9378
pubmed: 28241154
Zhou, W., & Benharash, P. (2014). Significance of "Deqi" response in acupuncture treatment: Myth or reality. Journal of Acupuncture and Meridian Studies, 7(4), 186–189. https://doi.org/10.1016/j.jams.2014.02.008 .
doi: 10.1016/j.jams.2014.02.008
pubmed: 25151451
Zhou, G., Qin, W., Zeng, F., Liu, P., Yang, X., von Deneen, K. M., et al. (2013). White-matter microstructural changes in functional dyspepsia: A diffusion tensor imaging study. The American Journal of Gastroenterology, 108(2), 260–269. https://doi.org/10.1038/ajg.2012.405 .
doi: 10.1038/ajg.2012.405
pubmed: 23229422
Zung, W. W. (1965). A SELF-RATING DEPRESSION SCALE. Archives of General Psychiatry, 12, 63–70. https://doi.org/10.1001/archpsyc.1965.01720310065008 .
doi: 10.1001/archpsyc.1965.01720310065008
pubmed: 14221692
Zung, W. W. (1971). A rating instrument for anxiety disorders. Psychosomatics, 12(6), 371–379. https://doi.org/10.1016/s0033-3182(71)71479-0 .
doi: 10.1016/s0033-3182(71)71479-0
pubmed: 5172928