Tuning coordination chemistry through the second sphere in designed metallocoiled coils.

Amino Acid Sequence Binding Sites Coordination Complexes / chemistry Gadolinium / chemistry Peptides / chemistry Protein Binding

Journal

Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838

Informations de publication

Date de publication:
04 Apr 2020
Historique:
pubmed: 5 3 2020
medline: 21 11 2020
entrez: 5 3 2020
Statut: ppublish

Résumé

The metal hydration state within a designed coiled coil can be progressively tuned across the full integer range (3 → 0 aqua ligands), by careful choice of a second sphere terminal residue, including the lesser used Trp. Potential implications include a four-fold change in MRI relaxivity when applied to lanthanide coiled coils.

Identifiants

DOI: 10.1039/c9cc08189e PMID: 32129331
pubmed: 32129331
doi: 10.1039/c9cc08189e
doi:

Substances chimiques

Coordination Complexes 0
Peptides 0
Gadolinium AU0V1LM3JT

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3729-3732

Auteurs

Louise N Slope (LN)

School of Chemistry, University of Birmingham, Edgbaston, B15 2TT, UK. a.f.a.peacock@bham.ac.uk.

Michael G Hill (MG)

School of Chemistry, University of Birmingham, Edgbaston, B15 2TT, UK. a.f.a.peacock@bham.ac.uk.

Catherine F Smith (CF)

School of Chemistry, University of Birmingham, Edgbaston, B15 2TT, UK. a.f.a.peacock@bham.ac.uk.

Paul Teare (P)

School of Chemistry, University of Birmingham, Edgbaston, B15 2TT, UK. a.f.a.peacock@bham.ac.uk.

Felicity J de Cogan (FJ)

Institute of Microbiology and Infection, University of Birmingham, B15 2TT, UK.

Melanie M Britton (MM)

School of Chemistry, University of Birmingham, Edgbaston, B15 2TT, UK. a.f.a.peacock@bham.ac.uk.

Anna F A Peacock (AFA)

School of Chemistry, University of Birmingham, Edgbaston, B15 2TT, UK. a.f.a.peacock@bham.ac.uk.
ORCID: 0000-0001-6809-9295

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › Tuning coordination chemistry through the...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Tuning coordination chemistry through the...
questionsmedicales.fr › Composés chimiques organiques › Complexes de coordination › Tuning coordination chemistry through the...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Terres rares › Lanthanides › Gadolinium › Tuning coordination chemistry through the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Tuning coordination chemistry through the...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Tuning coordination chemistry through the...