Platelet factor 4 inhibits ADAMTS13 activity and regulates the multimeric distribution of von Willebrand factor.
ADAMTS13
platelet factor 4
platelets
thrombosis
von Willebrand factor
Journal
British journal of haematology
ISSN: 1365-2141
Titre abrégé: Br J Haematol
Pays: England
ID NLM: 0372544
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
24
10
2019
accepted:
03
02
2020
pubmed:
5
3
2020
medline:
5
3
2021
entrez:
5
3
2020
Statut:
ppublish
Résumé
The efficiency of von Willebrand factor (VWF) in thrombus formation is related to its multimeric size, which is controlled by the protease ADAMTS13. However, it is not clear what regulates ADAMTS13 activity. In this study, we investigated whether PF4 could bind to VWF and inhibit ADAMTS13 activity. We found that PF4 binds to VWF and protects against ADAMTS13 activity. We also found that VWF-PF4 complexes circulate in patients with thrombotic thrombocytopenic purpura (TTP). Our data provides the first evidence that PF4 may have a novel role in regulating VWF multimers during primary haemostasis and thrombosis.
Substances chimiques
PF4 protein, human
0
von Willebrand Factor
0
Platelet Factor 4
37270-94-3
ADAMTS13 Protein
EC 3.4.24.87
ADAMTS13 protein, human
EC 3.4.24.87
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
594-598Subventions
Organisme : CIHR
Pays : Canada
Informations de copyright
© 2020 British Society for Haematology and John Wiley & Sons Ltd.
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