Ratiometric population sensing by a pump-probe signaling system in Bacillus subtilis.


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
04 03 2020
Historique:
received: 22 02 2019
accepted: 04 02 2020
entrez: 6 3 2020
pubmed: 7 3 2020
medline: 27 6 2020
Statut: epublish

Résumé

Communication by means of diffusible signaling molecules facilitates higher-level organization of cellular populations. Gram-positive bacteria frequently use signaling peptides, which are either detected at the cell surface or 'probed' by intracellular receptors after being pumped into the cytoplasm. While the former type is used to monitor cell density, the functions of pump-probe networks are less clear. Here we show that pump-probe networks can, in principle, perform different tasks and mediate quorum-sensing, chronometric and ratiometric control. We characterize the properties of the prototypical PhrA-RapA system in Bacillus subtilis using FRET. We find that changes in extracellular PhrA concentrations are tracked rather poorly; instead, cells accumulate and strongly amplify the signal in a dose-dependent manner. This suggests that the PhrA-RapA system, and others like it, have evolved to sense changes in the composition of heterogeneous populations and infer the fraction of signal-producing cells in a mixed population to coordinate cellular behaviors.

Identifiants

pubmed: 32132526
doi: 10.1038/s41467-020-14840-w
pii: 10.1038/s41467-020-14840-w
pmc: PMC7055314
doi:

Substances chimiques

ATP-Binding Cassette Transporters 0
Bacterial Proteins 0
rapA protein, Bacillus subtilis 147605-09-2
Phosphoprotein Phosphatases EC 3.1.3.16

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1176

Références

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Auteurs

Heiko Babel (H)

BioQuant Center of the University of Heidelberg, Im Neuenheimer Feld 267, 69120, Heidelberg, Germany.
Center for Molecular Biology (ZMBH), University of Heidelberg, Im Neuenheimer Feld 282, 69120, Heidelberg, Germany.
Max-Planck-Institute for Terrestrial Microbiology, Karl-von-Frisch Str. 10, 35043, Marburg, Germany.

Pablo Naranjo-Meneses (P)

BioQuant Center of the University of Heidelberg, Im Neuenheimer Feld 267, 69120, Heidelberg, Germany.
Center for Molecular Biology (ZMBH), University of Heidelberg, Im Neuenheimer Feld 282, 69120, Heidelberg, Germany.
Max-Planck-Institute for Terrestrial Microbiology, Karl-von-Frisch Str. 10, 35043, Marburg, Germany.

Stephanie Trauth (S)

BioQuant Center of the University of Heidelberg, Im Neuenheimer Feld 267, 69120, Heidelberg, Germany.
Center for Molecular Biology (ZMBH), University of Heidelberg, Im Neuenheimer Feld 282, 69120, Heidelberg, Germany.
Max-Planck-Institute for Terrestrial Microbiology, Karl-von-Frisch Str. 10, 35043, Marburg, Germany.

Sonja Schulmeister (S)

BioQuant Center of the University of Heidelberg, Im Neuenheimer Feld 267, 69120, Heidelberg, Germany.
Center for Molecular Biology (ZMBH), University of Heidelberg, Im Neuenheimer Feld 282, 69120, Heidelberg, Germany.

Gabriele Malengo (G)

Max-Planck-Institute for Terrestrial Microbiology, Karl-von-Frisch Str. 10, 35043, Marburg, Germany.
LOEWE Center for Synthetic Microbiology (SYNMIKRO), Karl-von-Frisch Str. 16, 35043, Marburg, Germany.

Victor Sourjik (V)

Max-Planck-Institute for Terrestrial Microbiology, Karl-von-Frisch Str. 10, 35043, Marburg, Germany.
LOEWE Center for Synthetic Microbiology (SYNMIKRO), Karl-von-Frisch Str. 16, 35043, Marburg, Germany.

Ilka B Bischofs (IB)

BioQuant Center of the University of Heidelberg, Im Neuenheimer Feld 267, 69120, Heidelberg, Germany. ilka.bischofs@mpi-marburg.mpg.de.
Center for Molecular Biology (ZMBH), University of Heidelberg, Im Neuenheimer Feld 282, 69120, Heidelberg, Germany. ilka.bischofs@mpi-marburg.mpg.de.
Max-Planck-Institute for Terrestrial Microbiology, Karl-von-Frisch Str. 10, 35043, Marburg, Germany. ilka.bischofs@mpi-marburg.mpg.de.

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