Differential analysis of serum and urine S100 proteins in juvenile-onset systemic lupus erythematosus (jSLE).
Adolescent
Age of Onset
Biomarkers
/ blood
Calgranulin A
/ analysis
Calgranulin B
/ blood
Case-Control Studies
Child
Child, Preschool
Creatinine
/ blood
Female
Glomerulonephritis, IGA
/ blood
Humans
Lupus Erythematosus, Systemic
/ epidemiology
Lupus Nephritis
/ blood
Male
Prognosis
S100A12 Protein
/ blood
Severity of Illness Index
Young Adult
Biomarker
Juvenile-onset
Nephritis
S100
SLE
Journal
Clinical immunology (Orlando, Fla.)
ISSN: 1521-7035
Titre abrégé: Clin Immunol
Pays: United States
ID NLM: 100883537
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
15
01
2020
revised:
28
02
2020
accepted:
28
02
2020
pubmed:
7
3
2020
medline:
24
10
2020
entrez:
6
3
2020
Statut:
ppublish
Résumé
Up to 80% of juvenile-onset systemic lupus erythematosus (jSLE) patients develop lupus nephritis (LN) that affects treatment and prognosis. Easily accessible biomarkers do not exist to reliably diagnose LN, leaving kidney biopsies as the gold-standard. Calcium-binding S100 proteins are expressed by innate immune cells and epithelia and may act as biomarkers in systemic inflammatory conditions. We quantified S100 proteins in the serum and urine of jSLE patients, matched healthy and inflammatory (IgA vasculitis) controls. Serum S100A8/A9, and serum and urine S100A12 are increased in jSLE patients when compared to controls. Furthermore, serum S100A8/A9, and serum and urine S100A12 are increased in jSLE patients with active as compared to patients with inactive/no LN. No differences in S100A4 levels were seen between groups. This study demonstrates potential promise for S100A8/A9 and S100A12 as biomarkers for jSLE and active LN. Findings require to be confirmed and tested prospectively in independent and larger multi-ethnic cohorts.
Identifiants
pubmed: 32135275
pii: S1521-6616(20)30033-4
doi: 10.1016/j.clim.2020.108375
pii:
doi:
Substances chimiques
Biomarkers
0
Calgranulin A
0
Calgranulin B
0
S100A12 Protein
0
S100A12 protein, human
0
S100A8 protein, human
0
S100A9 protein, human
0
Creatinine
AYI8EX34EU
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108375Subventions
Organisme : Medical Research Council
ID : MR/M01665X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M01665X/1
Pays : United Kingdom
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.