Segregation of Dispersed Silica Nanoparticles in Microfluidic Water-in-Oil Droplets: A Kinetic Study.
Amines
/ chemistry
Animals
Cattle
DNA
/ chemistry
Fatty Acids, Monounsaturated
/ chemistry
Kinetics
Microfluidic Analytical Techniques
Mineral Oil
/ chemistry
Nanoparticles
/ chemistry
Particle Size
Quaternary Ammonium Compounds
/ chemistry
Serum Albumin, Bovine
/ chemistry
Silicon Dioxide
/ chemistry
Surface Properties
Water
/ chemistry
DNA nanostructures
automated analysis
segregation kinetics
self-assembly
silica nanoparticles
Journal
Chemphyschem : a European journal of chemical physics and physical chemistry
ISSN: 1439-7641
Titre abrégé: Chemphyschem
Pays: Germany
ID NLM: 100954211
Informations de publication
Date de publication:
18 05 2020
18 05 2020
Historique:
received:
05
12
2019
revised:
19
02
2020
pubmed:
7
3
2020
medline:
12
1
2021
entrez:
7
3
2020
Statut:
ppublish
Résumé
Dispersed negatively charged silica nanoparticles segregate inside microfluidic water-in-oil (W/O) droplets that are coated with a positively charged lipid shell. We report a methodology for the quantitative analysis of this self-assembly process. By using real-time fluorescence microscopy and automated analysis of the recorded images, kinetic data are obtained that characterize the electrostatically-driven self-assembly. We demonstrate that the segregation rates can be controlled by the installment of functional moieties on the nanoparticle's surface, such as nucleic acid and protein molecules. We anticipate that our method enables the quantitative and systematic investigation of the segregation of (bio)functionalized nanoparticles in microfluidic droplets. This could lead to complex supramolecular architectures on the inner surface of micrometer-sized hollow spheres, which might be used, for example, as cell containers for applications in the life sciences.
Identifiants
pubmed: 32142187
doi: 10.1002/cphc.201901151
pmc: PMC7317348
doi:
Substances chimiques
Amines
0
Fatty Acids, Monounsaturated
0
Quaternary Ammonium Compounds
0
Water
059QF0KO0R
Serum Albumin, Bovine
27432CM55Q
Silicon Dioxide
7631-86-9
Mineral Oil
8020-83-5
DNA
9007-49-2
1,2-dioleoyloxy-3-(trimethylammonium)propane
MR86K0XRQP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1070-1078Subventions
Organisme : German Research Foundation (DFG)
Pays : International
Organisme : China Scholarship Council (CSC)
Pays : International
Informations de copyright
© 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.
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