Directed Metabolic Pathway Evolution Enables Functional Pterin-Dependent Aromatic-Amino-Acid Hydroxylation in
5-Hydroxytryptophan
/ metabolism
Amino Acids, Aromatic
/ metabolism
Biopterins
/ analogs & derivatives
Dihydroxyphenylalanine
/ metabolism
Directed Molecular Evolution
/ methods
Escherichia coli
/ metabolism
GTP Cyclohydrolase
/ genetics
Hydroxylation
Metabolic Networks and Pathways
Mutation
Phenylalanine Hydroxylase
/ genetics
Pterins
/ metabolism
Tryptophan
/ metabolism
ALE
GTP cyclohydrolase
phenylalanine hydroxylase
tryptophan hydroxylase
tyrosine hydroxylase
Journal
ACS synthetic biology
ISSN: 2161-5063
Titre abrégé: ACS Synth Biol
Pays: United States
ID NLM: 101575075
Informations de publication
Date de publication:
20 03 2020
20 03 2020
Historique:
pubmed:
10
3
2020
medline:
23
2
2021
entrez:
10
3
2020
Statut:
ppublish
Résumé
Tetrahydrobiopterin-dependent hydroxylation of aromatic amino acids is the first step in the biosynthesis of many neuroactive compounds in humans. A fundamental challenge in building these pathways in
Identifiants
pubmed: 32149495
doi: 10.1021/acssynbio.9b00488
doi:
Substances chimiques
Amino Acids, Aromatic
0
Pterins
0
Biopterins
0
Dihydroxyphenylalanine
63-84-3
Tryptophan
8DUH1N11BX
5-Hydroxytryptophan
C1LJO185Q9
Phenylalanine Hydroxylase
EC 1.14.16.1
GTP Cyclohydrolase
EC 3.5.4.16
sapropterin
EGX657432I
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM