Critical Role of Transcript Cleavage in Arabidopsis RNA Polymerase II Transcriptional Elongation.
Amino Acid Sequence
Arabidopsis
/ enzymology
Cell Nucleus
/ metabolism
Cell Proliferation
Mutant Proteins
/ chemistry
Plant Roots
/ growth & development
Proteasome Endopeptidase Complex
/ metabolism
Proteolysis
RNA Polymerase II
/ metabolism
RNA, Messenger
/ genetics
Transcription Elongation, Genetic
Transcription, Genetic
Transcriptional Elongation Factors
/ chemistry
Transcriptome
/ genetics
Journal
The Plant cell
ISSN: 1532-298X
Titre abrégé: Plant Cell
Pays: England
ID NLM: 9208688
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
14
11
2019
revised:
10
02
2020
accepted:
05
03
2020
pubmed:
11
3
2020
medline:
29
1
2021
entrez:
11
3
2020
Statut:
ppublish
Résumé
Transcript elongation factors associate with elongating RNA polymerase II (RNAPII) to control the efficiency of mRNA synthesis and consequently modulate plant growth and development. Encountering obstacles during transcription such as nucleosomes or particular DNA sequences may cause backtracking and transcriptional arrest of RNAPII. The elongation factor TFIIS stimulates the intrinsic transcript cleavage activity of the polymerase, which is required for efficient rescue of backtracked/arrested RNAPII. A TFIIS mutant variant (TFIISmut) lacks the stimulatory activity to promote RNA cleavage, but instead efficiently inhibits unstimulated transcript cleavage by RNAPII. We could not recover viable Arabidopsis (
Identifiants
pubmed: 32152189
pii: tpc.19.00891
doi: 10.1105/tpc.19.00891
pmc: PMC7203918
doi:
Substances chimiques
Mutant Proteins
0
RNA, Messenger
0
Transcriptional Elongation Factors
0
transcription factor S-II
0
RNA Polymerase II
EC 2.7.7.-
Proteasome Endopeptidase Complex
EC 3.4.25.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1449-1463Informations de copyright
© 2020 American Society of Plant Biologists. All rights reserved.
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