The dual phosphodiesterase 3/4 inhibitor RPL554 stimulates rare class III and IV CFTR mutants.
Aminopyridines
/ pharmacology
Animals
Benzodioxoles
/ pharmacology
Bronchi
/ cytology
Cell Line
Colforsin
/ pharmacology
Cyclic AMP
/ metabolism
Cyclic Nucleotide Phosphodiesterases, Type 3
/ genetics
Cyclic Nucleotide Phosphodiesterases, Type 4
/ genetics
Cystic Fibrosis Transmembrane Conductance Regulator
/ agonists
Humans
Isoquinolines
/ pharmacology
Mutation
Phosphodiesterase 3 Inhibitors
/ pharmacology
Phosphodiesterase 4 Inhibitors
/ pharmacology
Primary Cell Culture
Pyrimidinones
/ pharmacology
Rats
Rats, Inbred F344
Thyroid Epithelial Cells
/ cytology
Transgenes
CFTR
RPL554
cyclic nucleotide phosphodiesterases
cystic fibrosis
Journal
American journal of physiology. Lung cellular and molecular physiology
ISSN: 1522-1504
Titre abrégé: Am J Physiol Lung Cell Mol Physiol
Pays: United States
ID NLM: 100901229
Informations de publication
Date de publication:
01 05 2020
01 05 2020
Historique:
pubmed:
12
3
2020
medline:
25
7
2020
entrez:
12
3
2020
Statut:
ppublish
Résumé
Over 2,000 mutations have been reported in the cystic fibrosis transmembrane conductance regulator (
Identifiants
pubmed: 32159371
doi: 10.1152/ajplung.00285.2019
doi:
Substances chimiques
Aminopyridines
0
Benzodioxoles
0
CFTR protein, human
0
Isoquinolines
0
Phosphodiesterase 3 Inhibitors
0
Phosphodiesterase 4 Inhibitors
0
Pyrimidinones
0
Cystic Fibrosis Transmembrane Conductance Regulator
126880-72-6
Colforsin
1F7A44V6OU
ensifentrine
3E3D8T1GIX
Cyclic AMP
E0399OZS9N
Cyclic Nucleotide Phosphodiesterases, Type 3
EC 3.1.4.17
Cyclic Nucleotide Phosphodiesterases, Type 4
EC 3.1.4.17
lumacaftor
EGP8L81APK
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
L908-L920Subventions
Organisme : CIHR
ID : PJT-156183
Pays : Canada