HIV-1-Specific Chimeric Antigen Receptor T Cells Fail To Recognize and Eliminate the Follicular Dendritic Cell HIV Reservoir


Journal

Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724

Informations de publication

Date de publication:
04 05 2020
Historique:
received: 03 02 2020
accepted: 04 03 2020
pubmed: 13 3 2020
medline: 27 10 2020
entrez: 13 3 2020
Statut: epublish

Résumé

The major obstacle to a cure for HIV infection is the persistence of replication-competent viral reservoirs during antiretroviral therapy. HIV-specific chimeric antigen receptor (CAR) T cells have been developed to target latently infected CD4

Identifiants

pubmed: 32161179
pii: JVI.00190-20
doi: 10.1128/JVI.00190-20
pmc: PMC7199392
pii:
doi:

Substances chimiques

Antibodies, Monoclonal 0
Antibodies, Viral 0
HIV Envelope Protein gp120 0
ICAM1 protein, human 0
Receptors, Antigen, T-Cell 0
Receptors, Chimeric Antigen 0
gp120 protein, Human immunodeficiency virus 1 0
Intercellular Adhesion Molecule-1 126547-89-5

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIAID NIH HHS
ID : UM1 AI126617
Pays : United States

Informations de copyright

Copyright © 2020 American Society for Microbiology.

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Auteurs

Matthew T Ollerton (MT)

Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA.

Edward A Berger (EA)

Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Elizabeth Connick (E)

Department of Medicine, University of Arizona, Tucson, Arizona, USA connicke@deptofmed.arizona.edu.

Gregory F Burton (GF)

Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA.

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Classifications MeSH