Prognostic prediction of apparent diffusion coefficient obtained by diffusion-weighted MRI in mass-forming intrahepatic cholangiocarcinoma.
Aged
Algorithms
Bile Duct Neoplasms
/ diagnostic imaging
Biomarkers, Tumor
/ metabolism
Cholangiocarcinoma
/ diagnostic imaging
Contrast Media
Diffusion Magnetic Resonance Imaging
/ methods
Female
Hepatectomy
Humans
Hypoxia-Inducible Factor 1, alpha Subunit
/ metabolism
Male
Neoplasm Invasiveness
Prognosis
Survival Rate
Tomography, X-Ray Computed
apparent diffusion coefficient
hypoxia-inducible factor-1
intrahepatic cholangiocarcinoma
magnetic resonance imaging
prognostic prediction
Journal
Journal of hepato-biliary-pancreatic sciences
ISSN: 1868-6982
Titre abrégé: J Hepatobiliary Pancreat Sci
Pays: Japan
ID NLM: 101528587
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
30
08
2019
revised:
11
02
2020
accepted:
02
03
2020
pubmed:
13
3
2020
medline:
17
7
2021
entrez:
13
3
2020
Statut:
ppublish
Résumé
We evaluated apparent diffusion coefficient (ADC) of diffusion-weighted image MRI as a prognostic factor for mass-forming intrahepatic cholangiocarcinoma (IHCC). We enrolled 26 patients who had undergone hepatic resections for mass-forming-type IHCC in this study, and calculated their mean ADC, using diffusion-weighted image MRI (b: 0, 20, 800 seconds/mm Median age in the ADC The ADC values in MRIs can predict IHCC prognosis, and correlated with stromal density and HIF-1α expression.
Sections du résumé
BACKGROUND
BACKGROUND
We evaluated apparent diffusion coefficient (ADC) of diffusion-weighted image MRI as a prognostic factor for mass-forming intrahepatic cholangiocarcinoma (IHCC).
METHODS
METHODS
We enrolled 26 patients who had undergone hepatic resections for mass-forming-type IHCC in this study, and calculated their mean ADC, using diffusion-weighted image MRI (b: 0, 20, 800 seconds/mm
RESULTS
RESULTS
Median age in the ADC
CONCLUSIONS
CONCLUSIONS
The ADC values in MRIs can predict IHCC prognosis, and correlated with stromal density and HIF-1α expression.
Substances chimiques
Biomarkers, Tumor
0
Contrast Media
0
HIF1A protein, human
0
Hypoxia-Inducible Factor 1, alpha Subunit
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
388-395Informations de copyright
© 2020 Japanese Society of Hepato-Biliary-Pancreatic Surgery.
Références
Shaib Y, El-Serag HB. The epidemiology of cholangiocarcinoma. Semin Liver Dis. 2004;24:115-25.
Razumilava N, Gores GJ. Cholangiocarcinoma. Lancet. 2014;383:2168-79.
Parikh T, Drew SJ, Lee VS, Wong S, Hecht EM, Babb JS, et al. Focal liver lesion detection and characterization with diffusion-weighted MR imaging: comparison with standard breath-hold T2-weighted imaging. Radiology. 2008;246:812-22.
Jiang T, Xu JH, Zou Y, Chen R, Peng LR, Zhou ZD, et al. Diffusion-weighted imaging (DWI) of hepatocellular carcinomas: a retrospective analysis of the correlation between qualitative and quantitative DWI and tumour grade. Clin Radiol. 2017;72:465-72.
Kurosawa J, Tawada K, Mikata R, Ishihara T, Tsuyuguchi T, Saito M, et al. Prognostic relevance of apparent diffusion coefficient obtained by diffusion-weighted MRI in pancreatic cancer. J Magn Reson Imaging. 2015;42:1532-7.
Parsian S, Giannakopoulos NV, Rahbar H, Rendi MH, Chai X, Partridge SC. Diffusion-weighted imaging reflects variable cellularity and stromal density present in breast fibroadenomas. Clin Imaging. 2016;40:1047-54.
Ma T, Yang S, Jing H, Cong L, Cao Z, Liu Z, et al. Apparent diffusion coefficients in prostate cancer: correlation with molecular markers Ki-67, HIF-1α and VEGF. NMR Biomed. 2018;31:e3884.
Spivak-Kroizman TR, Hostetter G, Posner R, Aziz M, Hu C, Demeure MJ, et al. Hypoxia triggers hedgehog-mediated tumor-stromal interactions in pancreatic cancer. Cancer Res. 2013;73:3235-47.
Morine Y, Shimada M, Utsunomiya T, Imura S, Ikemoto T, Mori H, et al. Hypoxia inducible factor expression in intrahepatic cholangiocarcinoma. Hepatogastroenterology. 2011;58:1439-44.
Lewis S, Besa C, Wagner M, Jhaveri K, Kihira S, Zhu H, et al. Prediction of the histopathologic findings of intrahepatic cholangiocarcinoma: qualitative and quantitative assessment of diffusion-weighted imaging. Eur Radiol. 2018;28:2047-57.
Liver Cancer Study Group of Japan. Clinical findings. In: Makuuchi M, editor. The general rules for the clinical and pathological study of primary liver cancer, 2nd English edn. Tokyo, Japan: Kanehara Co, 2003; p. 6-28.
Morine Y, Shimada M. The value of systematic lymph node dissection for intrahepatic cholangiocarcinoma from the viewpoint of liver lymphatics. J Gastroenterol. 2015;50:913-27.
Kajiyama K, Maeda T, Takenaka K, Sugimachi K, Tsuneyoshi M. The significance of stromal desmoplasia in intrahepatic cholangiocarcinoma: a special reference of ‘scirrhous- type’ and ‘nonscirrhous-type’ growth. Am J Surg Pathol. 1999;23:892-902.
Ishikawa D, Shimada M, Utsunomiya T, Morine Y, Imura S, Ikemoto T, et al. Effect of Twist and Bmi1 on intraductal papillary mucinous neoplasm of the pancreas. J Gastroenterol Hepatol. 2014;29:2032-7.
Zhao X, Gao S, Ren H, Sun W, Zhang H, Sun J, et al. Hypoxia-inducible factor-1 promotes pancreatic ductal adenocarcinoma invasion and metastasis by activating transcription of the actin-bundling protein fascin. Cancer Res. 2014;74:2455-64.
Naganawa S, Sato C, Kumada H, Ishigaki T, Miura S, Takizawa O. Apparent diffusion coefficient in cervical cancer of the uterus: comparison with the normal uterine cervix. Eur Radiol. 2005;15:71-8.
Di Costanzo A, Scarabino T, Trojsi F, Giannatempo GM, Popolizio T, Catapano D, et al. Multiparametric 3T MR approach to the assessment of cerebral gliomas: tumor extent and malignancy. Neuroradiology. 2006;48:622-31.
Sirica AE, Gores GJ. Desmoplastic stroma and cholangiocarcinoma: clinical implications and therapeutic targeting. Hepatology. 2014;59:2397-402.
Aoyagi T, Shuto K, Okazumi S, Hayano K, Satoh A, Saitoh H, et al. Apparent diffusion coefficient correlation with oesophageal tumour stroma and angiogenesis. Eur Radiol. 2012;22:1172-7.
Lee J, Kim SH, Kang TW, Song KD, Choi D, Jang KT. Mass-forming intrahepatic cholangiocarcinoma: diffusion-weighted imaging as a preoperative prognostic marker. Radiology. 2016;281:119-28.
Driessen JP, Caldas-Magalhaes J, Janssen LM, Pameijer FA, Kooij N, Terhaard CH, et al. Diffusion-weighted MR imaging in laryngeal and hypopharyngeal carcinoma: association between apparent diffusion coefficient and histologic findings. Radiology. 2014;272:456-63.
Ko ES, Han BK, Kim RB, Cho EY, Ahn S, Nam SJ, et al. Apparent diffusion coefficient in estrogen receptor-positive invasive ductal breast carcinoma: correlations with tumor-stroma ratio. Radiology. 2014;271:30-7.
Min JH, Kang TW, Cha DI, Kim SH, Shin KS, Lee JE, et al. Apparent diffusion coefficient as a potential marker for tumour differentiation, staging and long-term clinical outcomes in gallbladder cancer. Eur Radiol. 2019;29:411-21.
Muraoka N, Uematsu H, Kimura H, Imamura Y, Fujiwara Y, Murakami M, et al. Apparent diffusion coefficient in pancreatic cancer: characterization and histopathological correlations. J Magn Reson Imaging. 2008;27:1302-8.
Nanashima A, Sumida Y, Abo T, Oikawa M, Murakami G, Takeshita H, et al. Relationship between pattern of tumor enhancement and clinicopathologic characteristics in intrahepatic cholangiocarcinoma. J Surg Oncol. 2008;98:535-9.
Mavros MN, Economopoulos KP, Alexiou VG, Pawlik TM. Treatment and prognosis for patients with intrahepatic cholangiocarcinoma: systematic review and meta-analysis. JAMA Surg. 2014;149:565-74.
Vanichapol T, Leelawat K, Hongeng S. Hypoxia enhances cholangiocarcinoma invasion through activation of hepatocyte growth factor receptor and the extracellular signal-regulated kinase signaling pathway. Mol Med Rep. 2015;12:3265-72.
Kim SA, Lee JM, Lee KB, Kim SH, Yoon SH, Han JK, et al. Intrahepatic mass-forming cholangiocarcinomas: enhancement patterns at multiphasic CT, with special emphasis on arterial enhancement pattern-correlation with clinicopathologic findings. Radiology. 2011;260:148-57.
Mizuno T, Nagao M, Yamada Y, Narikiyo M, Ueno M, Miyagishi M, et al. Small interfering RNA expression vector targeting hypoxia-inducible factor 1 alpha inhibits tumor growth in hepatobiliary and pancreatic cancers. Cancer Gene Ther. 2006;13:131-40.
Cho SY, Park SJ, Kim SH, Han SS, Kim YK, Lee KW, et al. Survival analysis of intrahepatic cholangiocarcinoma after resection. Ann Surg Oncol. 2010;17:1823-30.
Hyder O, Marques H, Pulitano C, Marsh JW, Alexandrescu S, Bauer TW, et al. A nomogram to predict long-term survival after resection for intrahepatic cholangiocarcinoma: an Eastern and Western experience. JAMA Surg. 2014;149:432-8.
Jutric Z, Johnston WC, Hoen HM, Newell PH, Cassera MA, Hammill CW, et al. Impact of lymph node status in patients with intrahepatic cholangiocarcinoma treated by major hepatectomy: a review of the National Cancer Database. HPB (Oxford). 2016;18:79-87.
Morine Y, Shimada M, Ikegami T, Imura S, Kanemura H, Arakawa Y, et al. Usefulness of gemcitabine combined with 5-fluorouracil and cisplatin (GFP) in patients for unresectable biliary carcinoma. Hepatogastroenterology. 2009;56:307-12.
Morine Y, Shimada M, Ikemoto T, Arakawa Y, Iwahashi S, Saito YU, et al. Effect of adjuvant gemcitabine combined with low-dose 5-fluorouracil and cisplatin chemotherapy for advanced biliary carcinoma. Anticancer Res. 2017;37:6421-8.