Megakaryocytes contain extranuclear histones and may be a source of platelet-associated histones during sepsis.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
12 03 2020
12 03 2020
Historique:
received:
19
09
2019
accepted:
24
02
2020
entrez:
14
3
2020
pubmed:
14
3
2020
medline:
24
11
2020
Statut:
epublish
Résumé
Histones are typically located within the intracellular compartment, and more specifically, within the nucleus. When histones are located within the extracellular compartment, they change roles and become damage-associated molecular patterns (DAMPs), promoting inflammation and coagulation. Patients with sepsis have increased levels of extracellular histones, which have been shown to correlate with poor prognosis and the development of sepsis-related sequelae, such as end-organ damage. Until now, neutrophils were assumed to be the primary source of circulating histones during sepsis. In this paper, we show that megakaryocytes contain extranuclear histones and transfer histones to their platelet progeny. Upon examination of isolated platelets from patients with sepsis, we identified that patients with sepsis have increased amounts of platelet-associated histones (PAHs), which appear to be correlated with the type of infection. Taken together, these results suggest that megakaryocytes and platelets may be a source of circulating histones during sepsis and should be further explored.
Identifiants
pubmed: 32165642
doi: 10.1038/s41598-020-61309-3
pii: 10.1038/s41598-020-61309-3
pmc: PMC7067782
doi:
Substances chimiques
Biomarkers
0
Histones
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4621Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM092804
Pays : United States
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