The primary cilium: Its role as a tumor suppressor organelle.
Cancer
HDAC6
Primary cilia
Journal
Biochemical pharmacology
ISSN: 1873-2968
Titre abrégé: Biochem Pharmacol
Pays: England
ID NLM: 0101032
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
22
01
2020
accepted:
06
03
2020
pubmed:
15
3
2020
medline:
23
10
2020
entrez:
15
3
2020
Statut:
ppublish
Résumé
The primary cilium is an organelle that nearly all cells within the body contain. Its function is to sense the extracellular environment through its abundance of receptors and linked signaling pathways, working as an antenna. Ciliary defects lead to different pathologies. In particular, many tumors lose primary cilia, and this is linked with negative implications for the cell such as an increase in malignancy. In this work we will go through the knowledge of the role of primary cilia in normal conditions, how it is involved in diverse signaling pathways, and in disease, particularly in cancer, highlighting its tumor suppressor properties.
Identifiants
pubmed: 32169416
pii: S0006-2952(20)30134-9
doi: 10.1016/j.bcp.2020.113906
pmc: PMC7231466
mid: NIHMS1578353
pii:
doi:
Substances chimiques
Tumor Suppressor Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
113906Subventions
Organisme : NCI NIH HHS
ID : R01 CA183764
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
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