Endothelial Glycocalyx.
Acute Kidney Injury
/ metabolism
Capillary Permeability
/ physiology
Critical Illness
Endothelium, Vascular
/ metabolism
Glycocalyx
/ metabolism
Humans
Hyperglycemia
/ metabolism
Hypernatremia
/ metabolism
Microcirculation
/ physiology
Reperfusion Injury
/ metabolism
Respiratory Distress Syndrome
/ metabolism
Sepsis
/ metabolism
Wounds and Injuries
/ metabolism
AKI
ARDS
Endothelial glycocalyx
Organ dysfunction
Septic injury
Shedding
Trauma
Journal
Critical care clinics
ISSN: 1557-8232
Titre abrégé: Crit Care Clin
Pays: United States
ID NLM: 8507720
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
entrez:
17
3
2020
pubmed:
17
3
2020
medline:
29
12
2020
Statut:
ppublish
Résumé
The endothelial glycocalyx (EG) is the most luminal layer of the blood vessel, growing on and within the vascular wall. Shedding of the EG plays a central role in many critical illnesses. Degradation of the EG is associated with increased morbidity and mortality. Certain illnesses and iatrogenic interventions can cause degradation of the EG. It is not known whether restitution of the EG promotes the survival of the patient. First trials that focus on the reorganization and/or restitution of the EG seem promising. Nevertheless, the step "from bench to bedside" is still a big one.
Identifiants
pubmed: 32172810
pii: S0749-0704(19)30102-2
doi: 10.1016/j.ccc.2019.12.007
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
217-232Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Disclosure All authors have nothing to disclose.