Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications.
Antifungal therapy
Antifungals
Cationic chitosan derivatives
Structural optimization strategy
Journal
Carbohydrate polymers
ISSN: 1879-1344
Titre abrégé: Carbohydr Polym
Pays: England
ID NLM: 8307156
Informations de publication
Date de publication:
15 May 2020
15 May 2020
Historique:
received:
07
11
2019
revised:
12
02
2020
accepted:
12
02
2020
entrez:
17
3
2020
pubmed:
17
3
2020
medline:
24
11
2020
Statut:
ppublish
Résumé
The increasing resistance of pathogen fungi poses a global public concern. There are several limitations in current antifungals, including few available fungicides, severe toxicity of some fungicides, and drug resistance. Therefore, there is an urgent need to develop new antifungals with novel targets. Chitosan has been recognized as a potential antifungal substance due to its good biocompatibility, biodegradability, non-toxicity, and availability in abundance, but its applications are hampered by the low charge density results in low solubility at physiological pH. It is believed that enhancing the positive charge density of chitosan may be the most effective approach to improve both its solubility and antifungal activity. Hence, this review mainly focuses on the structural optimization strategy of cationic chitosan and the potential antifungal applications. This review also assesses and comments on the challenges, shortcomings, and prospect of cationic chitosan derivatives as antifungal therapy.
Identifiants
pubmed: 32172836
pii: S0144-8617(20)30176-4
doi: 10.1016/j.carbpol.2020.116002
pii:
doi:
Substances chimiques
Antifungal Agents
0
Chitosan
9012-76-4
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
116002Informations de copyright
Copyright © 2020. Published by Elsevier Ltd.