Dandelion polyphenols protect against acetaminophen-induced hepatotoxicity in mice via activation of the Nrf-2/HO-1 pathway and inhibition of the JNK signaling pathway.
Acetaminophen
/ toxicity
Animals
Apoptosis
/ drug effects
Biomarkers
/ blood
Chemical and Drug Induced Liver Injury
/ prevention & control
Disease Models, Animal
Heme Oxygenase-1
/ metabolism
MAP Kinase Signaling System
/ drug effects
Male
Membrane Proteins
/ metabolism
Mice
NF-E2-Related Factor 2
/ metabolism
Oxidative Stress
/ drug effects
Plant Extracts
/ pharmacology
Polyphenols
/ pharmacology
Taraxacum
/ chemistry
APAP-induced liver injury
Anti-apoptosis
Anti-inflammation
Dandelion polyphenols
JNK pathways
Nrf-2/HO-1 pathways
Oxidative stress
Journal
Chinese journal of natural medicines
ISSN: 1875-5364
Titre abrégé: Chin J Nat Med
Pays: China
ID NLM: 101504416
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
04
11
2019
entrez:
17
3
2020
pubmed:
17
3
2020
medline:
23
9
2020
Statut:
ppublish
Résumé
We investigated the liver protective activity of dandelion polyphenols (DP) against acetaminophen (APAP; Paracetamol)-induced hepatotoxicity. Mice were acclimated for 1 week and randomly divided into the following groups (n = 9 per group): Control, APAP, APAP + DP (100 mg·kg
Identifiants
pubmed: 32172946
pii: S1875-5364(20)30011-X
doi: 10.1016/S1875-5364(20)30011-X
pii:
doi:
Substances chimiques
Biomarkers
0
Membrane Proteins
0
NF-E2-Related Factor 2
0
Nfe2l2 protein, mouse
0
Plant Extracts
0
Polyphenols
0
Acetaminophen
362O9ITL9D
Heme Oxygenase-1
EC 1.14.14.18
Hmox1 protein, mouse
EC 1.14.14.18
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
103-113Informations de copyright
Copyright © 2020 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.