LncRNA MAGI2-AS3 inhibits the self-renewal of leukaemic stem cells by promoting TET2-dependent DNA demethylation of the LRIG1 promoter in acute myeloid leukaemia.
Adaptor Proteins, Signal Transducing
/ genetics
Cell Line, Tumor
Cell Self Renewal
/ genetics
DNA Demethylation
DNA-Binding Proteins
/ metabolism
Dioxygenases
Gene Expression Regulation, Leukemic
Guanylate Kinases
/ genetics
Humans
Leukemia, Myeloid, Acute
/ genetics
Membrane Glycoproteins
/ genetics
Neoplastic Stem Cells
/ metabolism
Promoter Regions, Genetic
Protein Binding
Proto-Oncogene Proteins
/ metabolism
RNA Interference
RNA, Antisense
RNA, Long Noncoding
LRIG1
Long Non-Coding RNA
Magi2-AS3
TET2
acute Myeloid Leukaemia
demethylation
leukaemic Stem Cells
self-renewal
Journal
RNA biology
ISSN: 1555-8584
Titre abrégé: RNA Biol
Pays: United States
ID NLM: 101235328
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
pubmed:
17
3
2020
medline:
15
5
2021
entrez:
17
3
2020
Statut:
ppublish
Résumé
The presence or absence of cytogenetic mutations is proposed to be responsible for the pathogenesis of acute myeloid leukaemia (AML). However, the current classification system is inadequate to elucidate the molecular heterogeneity of the disease, and therapy failures frequently occur. Leukaemia stem cells (LSCs) initiate and maintain the clonal hierarchy of AML and exhibit properties of self-renewal remaining recalcitrant to conventional chemotherapy. In this study, we identified a novel long non-coding RNA (lncRNA) MAGI2 antisense RNA 3 (MAGI2-AS3) in AML and investigated its functional role in regulating LSCs self-renewal. LSCs were identified by immunoprofiling of CD34
Identifiants
pubmed: 32174258
doi: 10.1080/15476286.2020.1726637
pmc: PMC7549675
doi:
Substances chimiques
Adaptor Proteins, Signal Transducing
0
DNA-Binding Proteins
0
LRIG1 protein, human
0
Membrane Glycoproteins
0
Proto-Oncogene Proteins
0
RNA, Antisense
0
RNA, Long Noncoding
0
Dioxygenases
EC 1.13.11.-
TET2 protein, human
EC 1.13.11.-
Guanylate Kinases
EC 2.7.4.8
MAGI2 protein, human
EC 2.7.4.8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
784-793Références
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