Analysis of L-arginine:glycine amidinotransferase-, creatine- and homoarginine-dependent gene regulation in the murine heart.
Amidinotransferases
/ metabolism
Animals
Arginine
/ metabolism
Connective Tissue Growth Factor
Creatine
/ metabolism
Desmocollins
Disease Models, Animal
Energy Metabolism
/ genetics
Fibrinogen
Gene Expression Regulation
/ genetics
Genetic Association Studies
Homoarginine
/ metabolism
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
Mice, Transgenic
Myocardial Infarction
/ etiology
Myocardium
/ immunology
Potassium Channels
Transcriptome
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
16 03 2020
16 03 2020
Historique:
received:
21
11
2019
accepted:
06
02
2020
entrez:
18
3
2020
pubmed:
18
3
2020
medline:
15
12
2020
Statut:
epublish
Résumé
L-arginine:glycine amidinotransferase (AGAT) and its metabolites creatine and homoarginine (HA) have been linked to cardiovascular pathologies in both human and murine studies, but the underlying molecular mechanisms are poorly understood. Here, we report the first analysis of heart transcriptome variation using microarrays in an AGAT-deficient (AGAT
Identifiants
pubmed: 32179820
doi: 10.1038/s41598-020-61638-3
pii: 10.1038/s41598-020-61638-3
pmc: PMC7076046
doi:
Substances chimiques
CCN2 protein, mouse
0
Desmocollins
0
Dsc2 protein, mouse
0
Fgl2 protein, mouse
0
Hcn2 protein, mouse
0
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
0
Potassium Channels
0
Connective Tissue Growth Factor
139568-91-5
Homoarginine
156-86-5
Fibrinogen
9001-32-5
Arginine
94ZLA3W45F
Amidinotransferases
EC 2.1.4.-
glycine amidinotransferase
EC 2.1.4.1
Creatine
MU72812GK0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4821Références
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