A Role for MMP-10 (Matrix Metalloproteinase-10) in Calcific Aortic Valve Stenosis.
Adult
Aged
Aortic Valve
/ enzymology
Aortic Valve Stenosis
/ enzymology
Calcinosis
/ enzymology
Case-Control Studies
Cells, Cultured
Female
Fibrosis
Humans
Inflammation Mediators
/ metabolism
Male
Matrix Metalloproteinase 10
/ genetics
Middle Aged
Osteogenesis
/ genetics
Phosphorylation
Prospective Studies
Proto-Oncogene Proteins c-akt
/ metabolism
Signal Transduction
Up-Regulation
aortic valve stenosis
blotting, Western
collagen
inflammation
interleukin-1
Journal
Arteriosclerosis, thrombosis, and vascular biology
ISSN: 1524-4636
Titre abrégé: Arterioscler Thromb Vasc Biol
Pays: United States
ID NLM: 9505803
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
pubmed:
20
3
2020
medline:
15
7
2020
entrez:
20
3
2020
Statut:
ppublish
Résumé
Aortic valve (AV) calcification plays an important role in the progression of aortic stenosis (AS). MMP-10 (matrix metalloproteinase-10 or stromelysin-2) is involved in vascular calcification in atherosclerosis. We hypothesize that MMP-10 may play a pathophysiological role in calcific AS. Approach and Results: Blood samples (n=112 AS and n=349 controls) and AVs (n=88) from patients undergoing valve replacement were analyzed. Circulating MMP-10 was higher in patients with AS compared with controls ( MMP-10, which is overexpressed in aortic valve from patients with AS, seems to play a central role in calcification in AS through Akt phosphorylation. MMP-10 could be a new therapeutic target for delaying the progression of aortic valve calcification in AS.
Identifiants
pubmed: 32188274
doi: 10.1161/ATVBAHA.120.314143
doi:
Substances chimiques
Inflammation Mediators
0
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
MMP10 protein, human
EC 3.4.24.22
Matrix Metalloproteinase 10
EC 3.4.24.22
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM