Amygdala, neuropeptides, and chronic pain-related affective behaviors.
Amygdala
CGPR
CRF
Opioids
Oxytocin
Pain
Vasopressin
Journal
Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217
Informations de publication
Date de publication:
15 06 2020
15 06 2020
Historique:
received:
03
12
2019
revised:
04
03
2020
accepted:
11
03
2020
pubmed:
20
3
2020
medline:
4
6
2021
entrez:
20
3
2020
Statut:
ppublish
Résumé
Neuropeptides play important modulatory roles throughout the nervous system, functioning as direct effectors or as interacting partners with other neuropeptide and neurotransmitter systems. Limbic brain areas involved in learning, memory and emotions are particularly rich in neuropeptides. This review will focus on the amygdala, a limbic region that plays a key role in emotional-affective behaviors and pain modulation. The amygdala is comprised of different nuclei; the basolateral (BLA) and central (CeA) nuclei and in between, the intercalated cells (ITC), have been linked to pain-related functions. A wide range of neuropeptides are found in the amygdala, particularly in the CeA, but this review will discuss those neuropeptides that have been explored for their role in pain modulation. Calcitonin gene-related peptide (CGRP) is a key peptide in the afferent nociceptive pathway from the parabrachial area and mediates excitatory drive of CeA neurons. CeA neurons containing corticotropin releasing factor (CRF) and/or somatostatin (SOM) are a source of long-range projections and serve major output functions, but CRF also acts locally to excite neurons in the CeA and BLA. Neuropeptide S (NPS) is associated with inhibitory ITC neurons that gate amygdala output. Oxytocin and vasopressin exert opposite (inhibitory and excitatory, respectively) effects on amygdala output. The opioid system of mu, delta and kappa receptors (MOR, DOR, KOR) and their peptide ligands (β-endorphin, enkephalin, dynorphin) have complex and partially opposing effects on amygdala function. Neuropeptides therefore serve as valuable targets to regulate amygdala function in pain conditions. This article is part of the special issue on Neuropeptides.
Identifiants
pubmed: 32188569
pii: S0028-3908(20)30118-0
doi: 10.1016/j.neuropharm.2020.108052
pmc: PMC7214122
mid: NIHMS1578766
pii:
doi:
Substances chimiques
AVP protein, human
0
Neuropeptides
0
Neurophysins
0
Protein Precursors
0
neuropeptide S, human
0
Vasopressins
11000-17-2
Oxytocin
50-56-6
Corticotropin-Releasing Hormone
9015-71-8
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
108052Subventions
Organisme : NIAAA NIH HHS
ID : R01 AA027096
Pays : United States
Organisme : NIDA NIH HHS
ID : P01 DA041307
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS109255
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS106902
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS038261
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA041809
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest There are no conflicts of interest.
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