Structural Biology of the Enterovirus Replication-Linked 5'-Cloverleaf RNA and Associated Virus Proteins.
SAXS
X-ray crystallography
enterovirus
nuclear magnetic resonance
picornavirus
structure
viral replication
Journal
Microbiology and molecular biology reviews : MMBR
ISSN: 1098-5557
Titre abrégé: Microbiol Mol Biol Rev
Pays: United States
ID NLM: 9706653
Informations de publication
Date de publication:
20 05 2020
20 05 2020
Historique:
entrez:
20
3
2020
pubmed:
20
3
2020
medline:
13
7
2021
Statut:
epublish
Résumé
Although enteroviruses are associated with a wide variety of diseases and conditions, their mode of replication is well conserved. Their genome is carried as a single, positive-sense RNA strand. At the 5' end of the strand is an approximately 90-nucleotide self-complementary region called the 5' cloverleaf, or the oriL. This noncoding region serves as a platform upon which host and virus proteins, including the 3B, 3C, and 3D virus proteins, assemble in order to initiate replication of a negative-sense RNA strand. The negative strand in turn serves as a template for synthesis of multiple positive-sense RNA strands. Building on structural studies of individual RNA stem-loops, the structure of the intact 5' cloverleaf from rhinovirus has recently been determined via nuclear magnetic resonance/small-angle X-ray scattering (NMR/SAXS)-based methods, while structures have also been determined for enterovirus 3A, 3B, 3C, and 3D proteins. Analysis of these structures, together with structural and modeling studies of interactions between host and virus proteins and RNA, has begun to provide insight into the enterovirus replication mechanism and the potential to inhibit replication by blocking these interactions.
Identifiants
pubmed: 32188627
pii: 84/2/e00062-19
doi: 10.1128/MMBR.00062-19
pmc: PMC7399744
pii:
doi:
Substances chimiques
5' Untranslated Regions
0
RNA, Viral
0
Viral Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 American Society for Microbiology.
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