Clinical Pharmacogenetics Implementation Consortium Guideline (CPIC) for CYP2C9 and Nonsteroidal Anti-Inflammatory Drugs.
Anti-Inflammatory Agents, Non-Steroidal
/ adverse effects
Clinical Decision-Making
Consensus
Cytochrome P-450 CYP2C9
/ genetics
Drug Interactions
Drug-Related Side Effects and Adverse Reactions
/ enzymology
Genotype
Humans
Pharmacogenetics
/ standards
Pharmacogenomic Testing
/ standards
Pharmacogenomic Variants
Phenotype
Predictive Value of Tests
Risk Assessment
Risk Factors
Journal
Clinical pharmacology and therapeutics
ISSN: 1532-6535
Titre abrégé: Clin Pharmacol Ther
Pays: United States
ID NLM: 0372741
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
05
12
2019
accepted:
29
02
2020
pubmed:
20
3
2020
medline:
25
5
2021
entrez:
20
3
2020
Statut:
ppublish
Résumé
Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used analgesics due to their lack of addictive potential. However, NSAIDs have the potential to cause serious gastrointestinal, renal, and cardiovascular adverse events. CYP2C9 polymorphisms influence metabolism and clearance of several drugs in this class, thereby affecting drug exposure and potentially safety. We summarize evidence from the published literature supporting these associations and provide therapeutic recommendations for NSAIDs based on CYP2C9 genotype (updates at www.cpicpgx.org).
Identifiants
pubmed: 32189324
doi: 10.1002/cpt.1830
pmc: PMC8080882
mid: NIHMS1687646
doi:
Substances chimiques
Anti-Inflammatory Agents, Non-Steroidal
0
CYP2C9 protein, human
EC 1.14.13.-
Cytochrome P-450 CYP2C9
EC 1.14.13.-
Types de publication
Journal Article
Meta-Analysis
Practice Guideline
Research Support, N.I.H., Extramural
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
191-200Subventions
Organisme : NIGMS NIH HHS
ID : R24 GM061374
Pays : United States
Organisme : NIGMS NIH HHS
ID : R24 GM115264
Pays : United States
Organisme : NHGRI NIH HHS
ID : U24 HG010135
Pays : United States
Organisme : NIGMS NIH HHS
ID : R24 GM123930
Pays : United States
Informations de copyright
© 2020 The Authors Clinical Pharmacology & Therapeutics © 2020 American Society for Clinical Pharmacology and Therapeutics.
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